Wendy S Beane

Wendy S Beane, Ph.D.

  • Positions:
    Post Doctoral Fellow

    Center for Regenerative and Developmental Biology

    Biology

    Tufts University (Medford, MA)

    Post Doctoral Fellow

    Regenerative and Developmental Biology

    Harvard School of Dental Medicine

    The Forsyth Institute (Boston, MA)

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  • Advisor:

    Michael Levin

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  • Degrees:
     
    Ph.D., Biology, Duke University (Durham, NC)
     
    B.S., Biomedical Science, Averett University (Danville, VA)
     
    B.A., English, Averett University (Danville, VA)
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  • Past Advisors:
     
    David R. McClay (as Post Doctoral Fellow)
     
    David R. McClay (as Graduate Student - Ph.D.)
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  • Research:
    Regeneration of Anterior-Posterior Axial Polarity in Planaria

    Clinical applications arising from stem cell and regeneration research will require an understanding not only of de novo tissue synthesis but also of the patterning mechanisms regulating blastema morphology. This project seeks to elucidate the regulatory networks controlled by biophysical epigenetic changes which orient blastema polarity relative to existing tissues. Our hypothesis is that ion transport and gap junctional communication together regulate anterior-posterior polarity during planarian regeneration upstream of traditional signaling. We aim to identify and characterize transcriptional targets downstream of ion transport, and then build and test models which outline the mechanisms ion transporters use to control axial identity in regenerating tissue. The long-term goal is to compile and validate a systems-level regeneration network model integrating biophysical and biochemical signaling. This has the potential for use as a predictive model of morphogenesis to aid in the translation of basic regeneration research into practical biomedical therapies.

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  • Other Experience:

    1999-2001 Undergraduate Research at Averett College with Dr. Edward Fisher (Microbial Analyses of Rhizosphere Soil from Coastal Boreal Forest)

    1997 Cystic Fibrosis Fellowship for Summer Undergraduate Research / UNC-Chapel Hill with Dr. Sharon Milgram

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  • Honors:

    2008-present Ruth L. Kirschstein National Research Service Award

    2008 Tuition Grant, Cold Spring Harbor Laboratories, Ion Channel Physiology Course

    2006 Tuition Grant, American Physiological Society, Professional Skills Course on Writing and Reviewing for Scientific Journals

    2004 Second Place, Student Poster Competition, SDB 63rd Annual Meeting

    2004 Graduate Student Symposium Departmental Award (Biology Department), Duke University

    2001 Elizabeth and James Bustard Distinguished Scholar Award

    1997 Student Undergraduate Traineeship Grant, Cystic Fibrosis Foundation

    1996 American Legion Citizenship Award

    1996 Outstanding Student in English Award

Life Sciences
Communities:

Wendy Beane's Genealogy

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Wendy Beane's Publications (5)

  • Lineage-specific expansions provide genomic complexity among sea urchin GTPases.

    Beane WS, Voronina E, Wessel GM, McClay DR

    Developmental biology. 2006 Dec 1;300(1):165-79
  • The sea urchin kinome: a first look.

    Bradham CA, Foltz KR, Beane WS, Arnone MI, Rizzo F, Coffman JA, Mushegian A, Goel M, Morales J, Geneviere AM, Lapraz F, Robertson AJ, Kelkar H, Loza-Coll M, Townley IK, Raisch M, Roux MM, Lepage T, Gache C, McClay DR, Manning G

    Developmental biology. 2006 Dec 1;300(1):180-93
  • Translational control genes in the sea urchin genome.

    Morales J, Mulner-Lorillon O, Cosson B, Morin E, Bellé R, Bradham CA, Beane WS, Cormier P

    Developmental biology. 2006 Dec 1;300(1):293-307
  • The genome of the sea urchin Strongylocentrotus purpuratus.

    Sodergren E, Weinstock GM, Davidson EH, Cameron RA, Gibbs RA, Angerer RC, Angerer LM, Arnone MI, Burgess DR, Burke RD, Coffman JA, Dean M, Elphick MR, Ettensohn CA, Foltz KR, Hamdoun A, Hynes RO, Klein WH, Marzluff W, McClay DR, Morris RL, Mushegian A, Rast JP, Smith LC, Thorndyke MC, Vacquier VD, Wessel GM, Wray G, Zhang L, Elsik CG, Ermolaeva O, Hlavina W, Hofmann G, Kitts P, Landrum MJ, Mackey AJ, Maglott D, Panopoulou G, Poustka AJ, Pruitt K, Sapojnikov V, Song X, Souvorov A, Solovyev V, Wei Z, Whittaker CA, Worley K, Durbin KJ, Shen Y, Fedrigo O, Garfield D, Haygood R, Primus A, Satija R, Severson T, Gonzalez-Garay ML, Jackson AR, Milosavljevic A, Tong M, Killian CE, Livingston BT, Wilt FH, Adams N, Bellé R, Carbonneau S, Cheung R, Cormier P, Cosson B, Croce J, Fernandez-Guerra A, Genevière AM, Goel M, Kelkar H, Morales J, Mulner-Lorillon O, Robertson AJ, Goldstone JV, Cole B, Epel D, Gold B, Hahn ME, Howard-Ashby M, Scally M, Stegeman JJ, Allgood EL, Cool J, Judkins KM, McCafferty SS, Musante AM, Obar RA, Rawson AP, Rossetti BJ, Gibbons IR, Hoffman MP, Leone A, Istrail S, Materna SC, Samanta MP, Stolc V, Tongprasit W, Tu Q, Bergeron KF, Brandhorst BP, Whittle J, Berney K, Bottjer DJ, Calestani C, Peterson K, Chow E, Yuan QA, Elhaik E, Graur D, Reese JT, Bosdet I, Heesun S, Marra MA, Schein J, Anderson MK, Brockton V, Buckley KM, Cohen AH, Fugmann SD, Hibino T, Loza-Coll M, Majeske AJ, Messier C, Nair SV, Pancer Z, Terwilliger DP, Agca C, Arboleda E, Chen N, Churcher AM, Hallböök F, Humphrey GW, Idris MM, Kiyama T, Liang S, Mellott D, Mu X, Murray G, Olinski RP, Raible F, Rowe M, Taylor JS, Tessmar-Raible K, Wang D, Wilson KH, Yaguchi S, Gaasterland T, Galindo BE, Gunaratne HJ, Juliano C, Kinukawa M, Moy GW, Neill AT, Nomura M, Raisch M, Reade A, Roux MM, Song JL, Su YH, Townley IK, Voronina E, Wong JL, Amore G, Branno M, Brown ER, Cavalieri V, Duboc V, Duloquin L, Flytzanis C, Gache C, Lapraz F, Lepage T, Locascio A, Martinez P, Matassi G, Matranga V, Range R, Rizzo F, Röttinger E, Beane W, Bradham C, Byrum C, Glenn T, Hussain S, Manning G, Miranda E, Thomason R, Walton K, Wikramanayke A, Wu SY, Xu R, Brown CT, Chen L, Gray RF, Lee PY, Nam J, Oliveri P, Smith J, Muzny D, Bell S, Chacko J, Cree A, Curry S, Davis C, Dinh H, Dugan-Rocha S, Fowler J, Gill R, Hamilton C, Hernandez J, Hines S, Hume J, Jackson L, Jolivet A, Kovar C, Lee S, Lewis L, Miner G, Morgan M, Nazareth LV, Okwuonu G, Parker D, Pu LL, Thorn R, Wright R

    Science (New York, N.Y.). 2006 Nov 10;314(5801):941-52
  • RhoA regulates initiation of invagination, but not convergent extension, during sea urchin gastrulation.

    Beane WS, Gross JM, McClay DR

    Developmental biology. 2006 Apr 1;292(1):213-25


Wendy Beane's Posters and Presentations (15)

  • Gene Regulatory Networks Governing Morphogenesis (poster)

    McClay DR, Croce JC, Wu SY, Beane WS, Walton KD

    Society for Developmental Biology, 67th Annual Meeting; 07/2008
  • A Role for Calcium Signaling in Oral/Aboral Specification (presentation)

    Wendy S Beane

    Developmental Biology of the Sea Urchin XVIII; 04/2008
  • Patterning the Sea Urchin Skeleton: A Role for Calcium Signaling (poster)

    Beane WS, Walker MA, Jung D, Herman, L, Koff JL, Bradham CA, McClay DR

    Society for Developmental Biology, 66th Annual Meeting and First Pan American Congress; 06/2007
  • Patterning the Sea Urchin Skeleton: A Role for Calcium Signaling (poster)

    Beane WS, Bradham, CA, McClay DR

    Society for Developmental Biology, Southeast Regional Meeting; 05/2007
  • The Role of RhoA in Specifying Endomesoderm (presentation)

    Wendy S Beane

    DCMB Departmental Seminar, Duke University; 11/2006
  • The GTPase RhoA, SoxB1 Clearance and Endomesodermal Specification (presentation)

    Wendy S Beane

    Developmental Biology of the Sea Urchin XVII; 09/2006
  • Clearing the Way: The Small GTPase RhoA and Endomesodermal Specification (poster)

    Beane WS, McClay DR

    Society for Developmental Biology, 65th Annual Meeting; 06/2006
  • RhoA: Connecting Morphogenesis and Specification in the Sea Urchin (presentation)

    Wendy S Beane

    DCMB Departmental Seminar, Duke University; 10/2005
  • RhoA Triggers Endoderm Invagination During Sea Urchin Gastrulation (poster)

    Beane WS, Gross JM, McClay DR

    Society for Developmental Biology, 64th Annual Meeting; 07/2005
  • The Small GTPase RhoA and Gastrulation (presentation)

    Wendy S Beane

    Developmental Biology of the Sea Urchin XVI; 04/2005
  • The Small GTPase RhoA is Essential for Gastrulation in the Sea Urchin. (poster)

    Beane WS, Gross JM, McClay DR

    The American Society for Cell Biology, 44th Annual Meeting; 12/2004
  • The small GTPase RhoA is Required for Gastrulation in the Sea Urchin (presentation)

    Wendy S Beane

    DCMB Departmental Seminar, Duke University; 11/2004
  • The Small GTPase RhoA is Required for Sea Urchin Gastrulation (presentation)

    Wendy S Beane

    Duke University Biological Sciences Graduate Student Symposium, 13th Annual; 11/2004
  • RhoA is Required for Gastrulation in the Sea Urchin (poster)

    Beane WS, Gross JM, McClay DR

    Society for Developmental Biology, 63rd Annual Meeting; 07/2004
  • RhoA is Required for Archenteron Formation (poster)

    Beane WS, Gross JM, McClay DR

    Developmental Biology of Sea Urchins and Other Basal Deuterostomes XV; 09/2003

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