Epernicus: William J McGrath, Ph.D.

William J McGrath, Ph.D.

Position:
Research Associate

Biology

Brookhaven National Laboratory (Upton, NY)
Advisor:
Walter F. Mangel
Degrees:

Ph.D., Biochemistry, University of Vermont College of Medicine

B.A., Biology, Widener University (Chester, PA)
Past Advisors:

William L Meyer (as Graduate Student - Ph.D.)
Research:

Communities:

William McGrath's Genealogy

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William McGrath's Publications (25)

Assay for the adenovirus proteinase: purification of the enzyme and synthesis of a fluorogenic substrate.
Mangel WF, McGrath WJ

Methods in molecular medicine. 2007;131:257-67
Cofactors of the adenovirus proteinase: measuring equilibrium dissociation constants and stoichiometries of binding.
Mangel WF, McGrath WJ

Methods in molecular medicine. 2007;131:269-80
SARS CoV main proteinase: The monomer-dimer equilibrium dissociation constant.
Graziano V, McGrath WJ, Yang L, Mangel WF

Biochemistry. 2006 Dec 12;45(49):14632-41
Enzymatic activity of the SARS coronavirus main proteinase dimer.
Graziano V, McGrath WJ, DeGruccio AM, Dunn JJ, Mangel WF

FEBS letters. 2006 May 15;580(11):2577-83
Interaction of the adenovirus proteinase with protein cofactors with high negative charge densities.
Bajpayee NS, McGrath WJ, Mangel WF

Biochemistry. 2005 Jun 21;44(24):8721-9
DNA binding provides a molecular strap activating the adenovirus proteinase.
Gupta S, Mangel WF, McGrath WJ, Perek JL, Lee DW, Takamoto K, Chance MR

Molecular & cellular proteomics : MCP. 2004 Oct;3(10):950-9
Nitric oxide inhibits the adenovirus proteinase in vitro and viral infectivity in vivo.
Cao W, Baniecki ML, McGrath WJ, Bao C, Deming CB, Rade JJ, Lowenstein CJ, Mangel WF

The FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2003 Dec;17(15):2345-6
Specific interactions of the adenovirus proteinase with the viral DNA, an 11-amino-acid viral peptide, and the cellular protein actin.
Mangel WF, Baniecki ML, McGrath WJ

Cellular and molecular life sciences : CMLS. 2003 Nov;60(11):2347-55
Crystal structures of fusion proteins with large-affinity tags.
Smyth DR, Mrozkiewicz MK, McGrath WJ, Listwan P, Kobe B

Protein science : a publication of the Protein Society. 2003 Jul;12(7):1313-22
Crystallographic structure at 1.6-A resolution of the human adenovirus proteinase in a covalent complex with its 11-amino-acid peptide cofactor: insights on a new fold.
McGrath WJ, Ding J, Didwania A, Sweet RM, Mangel WF

Biochimica et biophysica acta. 2003 May 30;1648(1-2):1-11
Adenovirus proteinase: crystallization and preliminary X-ray diffraction studies to atomic resolution.
Baniecki ML, McGrath WJ, Dauter Z, Mangel WF

Acta crystallographica. Section D, Biological crystallography. 2002 Sep;58(Pt 9):1462-4
In the virion, the 11-amino-acid peptide cofactor pVIc is covalently linked to the adenovirus proteinase.
McGrath WJ, Aherne KS, Mangel WF

Virology. 2002 May 10;296(2):234-40
Roles of two conserved cysteine residues in the activation of human adenovirus proteinase.
McGrath WJ, Baniecki ML, Peters E, Green DT, Mangel WF

Biochemistry. 2001 Dec 4;40(48):14468-74
Human adenovirus proteinase: DNA binding and stimulation of proteinase activity by DNA.
McGrath WJ, Baniecki ML, Li C, McWhirter SM, Brown MT, Toledo DL, Mangel WF

Biochemistry. 2001 Nov 6;40(44):13237-45
Discovery of a new inhibitor lead of adenovirus proteinase: steps toward selective, irreversible inhibitors of cysteine proteinases.
Pang YP, Xu K, Kollmeyer TM, Perola E, McGrath WJ, Green DT, Mangel WF

FEBS letters. 2001 Aug 3;502(3):93-7
A new form of antiviral combination therapy predicted to prevent resistance from arising, and a model system to test it.
Mangel WF, McGrath WJ, Brown MT, Baniecki ML, Barnard DL, Pang YP

Current medicinal chemistry. 2001 Jul;8(8):933-9
Prevention of viral drug resistance by novel combination therapy.
Mangel WF, Brown MT, Baniecki ML, Barnard D, McGrath WJ

Current opinion in investigational drugs (London, England : 2000). 2001 May;2(5):613-6
Sensitive method to identify and characterize proteinases in situ after SDS-PAGE.
Williams J, McGrath WJ, Mangel WF

BioTechniques. 2000 Nov;29(5):1108-13
Temporal and spatial control of the adenovirus proteinase by both a peptide and the viral DNA.
Mangel WF, Toledo DL, Ding J, Sweet RM, McGrath WJ

Trends in biochemical sciences. 1997 Oct;22(10):393-8
Different modes of inhibition of human adenovirus proteinase, probably a cysteine proteinase, by bovine pancreatic trypsin inhibitor.
Brown MT, McGrath WJ, Toledo DL, Mangel WF

FEBS letters. 1996 Jun 17;388(2-3):233-7
Crystal structure of the human adenovirus proteinase with its 11 amino acid cofactor.
Ding J, McGrath WJ, Sweet RM, Mangel WF

The EMBO journal. 1996 Apr 15;15(8):1778-83
Characterization of human adenovirus proteinase activity in disrupted virus particles.
McGrath WJ, Abola AP, Toledo DL, Brown MT, Mangel WF

Virology. 1996 Mar 1;217(1):131-8
Characterization of three components of human adenovirus proteinase activity in vitro.
Mangel WF, Toledo DL, Brown MT, Martin JH, McGrath WJ

The Journal of biological chemistry. 1996 Jan 5;271(1):536-43
Preparation and crystallization of a complex between human adenovirus serotype 2 proteinase and its 11-amino-acid cofactor pVIc.
McGrath WJ, Ding J, Sweet RM, Mangel WF

Journal of structural biology. 1996 Jul-Aug;117(1):77-9
Viral DNA and a viral peptide can act as cofactors of adenovirus virion proteinase activity.
Mangel WF, McGrath WJ, Toledo DL, Anderson CW

Nature. 1993 Jan 21;361(6409):274-5

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William J McGrath, Ph.D.

Research Associate

William McGrath's Genealogy

William McGrath's Publications (25)