Walter (Eddie) Martucci

Walter (Eddie) Martucci, Ph.D.

  • Position:
    Senior Analyst

    PureTech Ventures (Boston, MA)

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  • Advisor:

    Karen S. Anderson

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  • Degrees:
     
    Ph.D., Molecular Biophysics and Biochemistry, Yale University (New Haven, CT)
     
    M.Phil., Molecular Biophysics and Biochemistry, Yale University (New Haven, CT)
     
    B.Sc., Biochemistry, Providence College (Providence, RI)
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  • Past Advisors:
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  • Research:
    Novel species-specific drug design for the protozoan parasite Cryptosporidium hominis

    The essential enzymes thymidylate synthase (TS) and dihydrofolate reductase (DHFR) are validated drug targets for infectious pathogens. These enyzymes are a single, bifunctional enzyme (TS-DHFR) in parasites, and therefore multiple protein surfaces exist that are absent in the human enzymes. Along with characterizing the effects of non-conserved amino acids at the active site, I am exploring the importance of some of these non-active site regions on enzyme function towards structure-based, species-specific inhibitor design. Cryptosporidium hominis is an intestinal parasite that causes gastrointestinal discomfort in healthy individuals, and a fatal "wasting disease" in immuno-compromised patients. There is currently an unmet need for therapeutics for the parasite.

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Life Sciences
Communities:

Walter (Eddie) Martucci's Genealogy

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Walter (Eddie) Martucci's Publications (4)



Walter (Eddie) Martucci's Posters and Presentations (3)

  • Validating a Parasite-Specific Drug Target in Cryptosporidium hominis TS-DHFR (presentation)

    Walter (Eddie) Martucci

    BWF Parasitology Conference; 08/2008
  • Validating a Parasite-Specific Drug Target in Cryptosporidium hominis TS-DHFR (poster)

    W. Eddie Martucci

    New England Structural Biology Association (NESBA); 06/2008
  • Toward Novel Inhibitor Development for a Bifunctional Parasitic Enzyme (presentation)

    W. Eddie Martucci

    Yale Chemical Biology Interface (CBI) Seminar Series; 04/2007

One Figure

One Figure for Walter (Eddie) Martucci

Docked inhibitor hit from a virtual screen of a Non-Active site pocket in ChTS-DHFR


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