Epernicus: Wilhelm A Weihofen, Ph.D.

Wilhelm A Weihofen, Ph.D.

Position:
Postdoc

Molecular and Cellular Biology

Harvard University (Cambridge, MA)
Advisor:
Rachelle Gaudet
Degrees:

Ph.D., Biochemistry, Free University of Berlin (Berlin, Germany)

Dipl. Chem., Biochemistry, University of Freiburg (Freiburg, Germany)
Past Advisors:

Wolfram Saenger (as Graduate Student - Ph.D.)

Georg E. Schulz (as Undergraduate Student)
Research:
Structural and biochemical studies of divalent metal ion transporters

Communities:

Wilhelm Weihofen's Genealogy

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Wilhelm Weihofen's Publications (10)

Streptococcus pyogenes pSM19035 requires dynamic assembly of ATP-bound ParA and ParB on parS DNA during plasmid segregation.
Pratto F, Cicek A, Weihofen WA, Lurz R, Saenger W, Alonso JC

Nucleic acids research. 2008 May 13
Structure of a herpesvirus-encoded cysteine protease reveals a unique class of deubiquitinating enzymes.
Schlieker C, Weihofen WA, Frijns E, Kattenhorn LM, Gaudet R, Ploegh HL

Molecular cell. 2007 Mar 9;25(5):677-87
Structures of human N-Acetylglucosamine kinase in two complexes with N-Acetylglucosamine and with ADP/glucose: insights into substrate specificity and regulation.
Weihofen WA, Berger M, Chen H, Saenger W, Hinderlich S

Journal of molecular biology. 2006 Dec 1;364(3):388-99
Structures of omega repressors bound to direct and inverted DNA repeats explain modulation of transcription.
Weihofen WA, Cicek A, Pratto F, Alonso JC, Saenger W

Nucleic acids research. 2006;34(5):1450-8
Crystal structures of HIV-1 Tat-derived nonapeptides Tat-(1-9) and Trp2-Tat-(1-9) bound to the active site of dipeptidyl-peptidase IV (CD26).
Weihofen WA, Liu J, Reutter W, Saenger W, Fan H

The Journal of biological chemistry. 2005 Apr 15;280(15):14911-7
Crystal structure of CD26/dipeptidyl-peptidase IV in complex with adenosine deaminase reveals a highly amphiphilic interface.
Weihofen WA, Liu J, Reutter W, Saenger W, Fan H

The Journal of biological chemistry. 2004 Oct 8;279(41):43330-5
Crystal structure of Homo sapiens protein hp14.5.
Manjasetty BA, Delbrück H, Pham DT, Mueller U, Fieber-Erdmann M, Scheich C, Sievert V, Büssow K, Niesen FH, Weihofen W, Loll B, Saenger W, Heinemann U, Neisen FH

Proteins. 2004 Mar 1;54(4):797-800
Recognition of DNA by omega protein from the broad-host range Streptococcus pyogenes plasmid pSM19035: analysis of binding to operator DNA with one to four heptad repeats.
de la Hoz AB, Pratto F, Misselwitz R, Speck C, Weihofen W, Welfle K, Saenger W, Welfle H, Alonso JC

Nucleic acids research. 2004;32(10):3136-47
Crystal structure of a squalene cyclase in complex with the potential anticholesteremic drug Ro48-8071.
Lenhart A, Weihofen WA, Pleschke AE, Schulz GE

Chemistry & biology. 2002 May;9(5):639-45
Thiol-modifying inhibitors for understanding squalene cyclase function.
Milla P, Lenhart A, Grosa G, Viola F, Weihofen WA, Schulz GE, Balliano G

European journal of biochemistry / FEBS. 2002 Apr;269(8):2108-16

One Figure

Crystals of a repressor-DNA complex

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