Vipender Singh, Ph.D.
- Positions:
Associate Research Fellow
Chemistry and Bioengineering
Massachusetts Institute of Technology (Cambridge, MA)
Associate Research Fellow
Molecular Biophysics and Biochemistry
Yale University (New Haven, CT)
- Advisor:
-
Degrees:
Ph.D., Chemical Biology, Albert Einstein College of Medicine (Bronx, New York)
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Past Advisors:
Scott A Strobel (as Post Doctoral Fellow)Vern L Schramm (as Graduate Student - Ph.D.)
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Research:
Study transition states of enzymes implicated cancer and bacterial pathogenesis with an aim to develop powerful transition state analogues.
Understand chemical mechanism of a DNA repair protein that is linked to obesity with an aim to develop powerful anti-obesity drugs.
Develop methods for studying sub-angstroms perturbations in nucleic acid polymers using heavy atom isotopes using RNA aptamers as model systems.
Develop a computer program to automate the process of theoretical determination of enzymatic transition states from experimental kinetic isotope effects.
Study tautomerism in nucleic acid polymers, a difficult problem that has remain unsolved for last four to five decades since the structure of DNA was solved by Watson and Crick.
Understand chemical mechanism of ribosome catalyzed peptide bond formation, a fundamental reaction in biology, using heavy atom isotope effects.
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Honors:
2010-present Ruth Kirschstein National Research Service Award for Postdoctoral Research
2010 Nature Chemical Biology Listed My Work On Mechanism-Based Femtomolar Inhibitors Among Top Discoveries of Last Decade
2007-2008 James Hudson Brown & Alexander Brown Coxe Postdoctoral Fellowship
2006 Julius Marmur Award for the Outstanding Graduate Research
2004 Best Poster Award at the Yale Chemical Biology Symposium
1996-1998 National Merit Based Scholarship from Government of India
Vipender Singh's Genealogy
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Vipender Singh's Publications (15)
Vipender Singh's Posters and Presentations (16)
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Transition States and Chemical Mechanisms of Enzymatic Reactions and Femtomolar Transition State Analogues (presentation)
Vipender Singh
Massachusetts Institute of Technology, Biological Chemistry Seminar Series; 10/2011 -
Transition States and Chemical Mechanisms of Enzymatic Reaction and Transition State Analogues (presentation)
Vipender Singh
Brown University, Organic Chemistry Series; 09/2011 -
Introduction to Bacterial Communication Systems; Bacterial Quorum Sensing (presentation)
Vipender Singh
Massachusetts Institute of Technology, Bioengineering Design Course (Course 20.380); 03/2011 -
Genome Fluidity and Tautomerism; A Study of Tautomerism in an RNA Aptamer. (presentation)
Vipender Singh
Massachusetts Institute of Technology, DNA Repair and Mutagenesis (DRAM), Department of Biological Engineering.; 02/2011 -
Transition States of Enzymes for Understanding Chemical Mechanisms and Design of Anticancer and Antibacterial Drugs with Femtomolar Binding Affinities (poster)
Vipender Singh
Koch Institute MIT, Symposium on Integrative Approaches to Cancer Research; 06/2010 -
Transition States of Enzymes for Understanding Chemical Mechanisms and Design of Anticancer and Antibacterial Drugs with Femtomolar Binding Affinities (poster)
Vipender Singh
Koch Institute MIT, Symposium on Integrative Approaches to Cancer Research; 06/2010 -
Transition States of Enzymatic Reactions and Femtomolar Transition State Analogues (poster)
Vipender Singh
Wesleyan University, Department of Chemistry; 02/2010 -
Transition State Analogues for MTAP and MTANs (presentation)
Vipender Singh
Julius Murmur Award lecture at the Einstein College of Medicine; 03/2006 -
Transition state of E. coli and S. pneumonia 5’-methylthioadenosine nucleosidase (MTAN). (poster)
Vipender Singh
American Chemical Society, Washington DC; 08/2005 -
Transition state structure and femtomolar transition analogue inhibitors of E. coli 5’- Methylthioadenosine nucleosidase.19th Enzyme Mechanisms Conference (poster)
Vipender Singh
Pacific Groove, California; 01/2005 -
Targeting Polyamine Pathway; Kinetic Isotope effects and transition state analogue inhibitors of 5’-Methylthioadenosine Phosphorylase (poster)
Vipender Singh
Yale Chemical Biology Symposium, Received Best Poster Award; 05/2004 -
Targeting Polyamine Pathway; Kinetic Isotope effects and transition state analogue inhibitors of 5'-Methylthioadenosine Phosphorylase (poster)
Vipender Singh
Gordon Research Conference on Isotope Effects, Ventura, California; 02/2004 -
Targeting Polyamine Pathway; transition state analogue inhibitors of 5’-Methylthioadenosine Phosphorylase (poster)
Vipender Singh
American Chemical Society, New York; 09/2003 -
Targeting Polyamine Pathway; transition state analogue inhibitors of 5’-Methylthioadenosine Phosphorylase (poster)
Vipender Singh
Gordon Conference on Enzyme Coenzyme and Metabolic Pathways, Kimball Union Academy, Meriden, New Hampshire; 07/2002 -
Transition State analogue inhibitors of 5’-Methylthioadenosine Phosphorylase and crystal structure with MT-Immucillin A (poster)
Vipender Singh
16th Enzyme Mechanism Conference, Galveston texas; 01/2002 -
Transition State analogue inhibitors of 5-Methylthioadenosine Phosphorylase (poster)
Vipender Singh
15th Enzyme Mechanisms Conference, Marco Island Florida; 01/2001
One Figure
Femtomolar transition state analogue inhibitor, MT-DADMe-ImmucillinA, in the active site of E. coli 5'-methylthioadenosine/S-adenosyl homocysteine nucleosidase
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