Epernicus: Todd W Geders, Ph.D.

Todd W Geders, Ph.D.

Positions:
Scientist II

R&D Systems

Post Doctoral Fellow

Medicinal Chemistry

University of Minnesota, Twin Cities (Minneapolis, MN)
Degrees:

Ph.D., Structural Biology, Purdue University (West Lafayette, IN)

B.S., Biochemistry, Purdue University (West Lafayette, IN)

B.S., Molecular Biology, Purdue University (West Lafayette, IN)
Past Advisors:

Barry C Finzel (as Post Doctoral Fellow)

Janet L Smith (as Graduate Student - Ph.D.)

Jillian M Buriak (as Undergraduate Student)
Research:
My research involved using X-ray crystallography as the primary tool to study protein function. I now do extensive work in protein production and assay development.

Communities:

Todd Geders's Genealogy

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Todd Geders's Publications (9)

Mechanism-based Inactivation by Aromatization of the Transaminase BioA Involved in Biotin Biosynthesis in Mycobaterium tuberculosis.
Shi C, Geders TW, Park SW, Wilson DJ, Boshoff HI, Abayomi O, Barry CE, Schnappinger D, Finzel BC, Aldrich CC

Journal of the American Chemical Society. 2011 Nov 16;133(45):18194-201
Identification of novel non-hydroxamate anthrax toxin lethal factor inhibitors by topomeric searching, docking and scoring, and in vitro screening.
Chiu TL, Solberg J, Patil S, Geders TW, Zhang X, Rangarajan S, Francis R, Finzel BC, Walters MA, Hook DJ, Amin EA

Journal of chemical information and modeling. 2009 Dec;49(12):2726-34
Metamorphic enzyme assembly in polyketide diversification.
Gu L, Wang B, Kulkarni A, Geders TW, Grindberg RV, Gerwick L, Håkansson K, Wipf P, Smith JL, Gerwick WH, Sherman DH

Nature. 2009 Jun 4;459(7247):731-5
Structural basis for binding specificity between subclasses of modular polyketide synthase docking domains.
Buchholz TJ, Geders TW, Bartley FE, Reynolds KA, Smith JL, Sherman DH

ACS chemical biology. 2009 Jan 16;4(1):41-52
Role for conserved residues of sindbis virus nonstructural protein 2 methyltransferase-like domain in regulation of minus-strand synthesis and development of cytopathic infection.
Mayuri, Geders TW, Smith JL, Kuhn RJ

Journal of virology. 2008 Aug;82(15):7284-97
Crystal structure of the ECH2 catalytic domain of CurF from Lyngbya majuscula. Insights into a decarboxylase involved in polyketide chain beta-branching.
Geders TW, Gu L, Mowers JC, Liu H, Gerwick WH, Håkansson K, Sherman DH, Smith JL

The Journal of biological chemistry. 2007 Dec 7;282(49):35954-63
GNAT-like strategy for polyketide chain initiation.
Gu L, Geders TW, Wang B, Gerwick WH, Håkansson K, Smith JL, Sherman DH

Science (New York, N.Y.). 2007 Nov 9;318(5852):970-4
Three Methods for Stabilization and Functionalization of Porous Silicon Surfaces via Hydrosilylation and Electrografting Reactions
Michael P Stewart, Edward G Robins, Todd W Geders, Matthew J Allen, Hee Cheul Choi, Jillian M Buriak

Physica Status Solida (a). 2000;182(1):109-115
Lewis acid mediated hydrosilylation on porous silicon surfaces
Jillian M Buriak, Michael P Stewart, Todd W Geders, Matthew J Allen, Hee Cheul Choi, Jay Smith, Daniel Raftery, Leigh T Canham

Journal of the American Chemical Society. 1999;121(49):11491-11502

One Figure

A collection of protein structures solved by the poster of viral proteins and polyketide synthase components.

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Todd W Geders, Ph.D.

Scientist II

Post Doctoral Fellow

My research involved using X-ray crystallography as the primary tool to study protein function. I now do extensive work in protein production and assay development.

Todd Geders's Genealogy

Todd Geders's Publications (9)

One Figure

Websites