Epernicus: Tivadar Orban, Ph.D.

Tivadar Orban, Ph.D.

Positions:
Research Associate (2010-present)

Pharmacology

Case Western Reserve University School of Medicine (Cleveland, OH)

Post Doctoral Fellow (2008-2010)

Pharmacology

Case Western Reserve University School of Medicine (Cleveland, OH)
Advisor:
Krzysztof Palczewski
Degrees:

Ph.D., Clinical/Bioanalytical Chemistry, Cleveland State University (Cleveland, OH)
Past Advisors:
Research:
Structural biology - applications using theoretical (molecular dynamics) and experimental techniques (mass spectrometry) to elucidate protein function.

Communities:

Tivadar Orban's Genealogy

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Tivadar Orban's Publications (11)

Conformational dynamics of activation for the pentameric complex of dimeric g protein-coupled receptor and heterotrimeric g protein.
Orban T, Jastrzebska B, Gupta S, Wang B, Miyagi M, Chance MR, Palczewski K

Structure (London, England : 1993). 2012 May 9;20(5):826-40
Substrate-Induced Changes in the Dynamics of Rhodopsin Kinase (G Protein-Coupled Receptor Kinase 1).
Orban T, Huang CC, Homan KT, Jastrzebska B, Tesmer JJ, Palczewski K

Biochemistry. 2012 Apr 11
Retinyl ester storage particles (retinosomes) from the retinal pigmented epithelium resemble lipid droplets in other tissues.
Orban T, Palczewska G, Palczewski K

The Journal of biological chemistry. 2011 May 13;286(19):17248-58
Activation of G protein-coupled receptor kinase 1 involves interactions between its N-terminal region and its kinase domain.
Huang CC, Orban T, Jastrzebska B, Palczewski K, Tesmer JJ

Biochemistry. 2011 Mar 22;50(11):1940-9
Visualizing water molecules in transmembrane proteins using radiolytic labeling methods.
Orban T, Gupta S, Palczewski K, Chance MR

Biochemistry. 2010 Feb 9;49(5):827-34
Conformational changes in guanylate cyclase-activating protein 1 induced by Ca2+ and N-terminal fatty acid acylation.
Orban T, Bereta G, Miyagi M, Wang B, Chance MR, Sousa MC, Palczewski K

Structure (London, England : 1993). 2010 Jan 13;18(1):116-26
Cooperative regulation of the activity of factor Xa within prothrombinase by discrete amino acid regions from factor Va heavy chain.
Barhoover MA, Orban T, Bukys MA, Kalafatis M

Biochemistry. 2008 Dec 2;47(48):12835-43
Contribution of amino acid region 334-335 from factor Va heavy chain to the catalytic efficiency of prothrombinase.
Barhoover MA, Orban T, Beck DO, Bukys MA, Kalafatis M

Biochemistry. 2008 Jul 1;47(26):6840-50
The interaction of fragment 1 of prothrombin with the membrane surface is a prerequisite for optimum expression of factor Va cofactor activity within prothrombinase.
Bukys MA, Orban T, Kim PY, Nesheim ME, Kalafatis M

Thrombosis and haemostasis. 2008 Mar;99(3):511-22
The structural integrity of anion binding exosite I of thrombin is required and sufficient for timely cleavage and activation of factor V and factor VIII.
Bukys MA, Orban T, Kim PY, Beck DO, Nesheim ME, Kalafatis M

The Journal of biological chemistry. 2006 Jul 7;281(27):18569-80
Completed three-dimensional model of human coagulation factor va. Molecular dynamics simulations and structural analyses.
Orban T, Kalafatis M, Gogonea V

Biochemistry. 2005 Oct 4;44(39):13082-90

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Tivadar Orban, Ph.D.

Research Associate (2010-present)

Post Doctoral Fellow (2008-2010)

Structural biology - applications using theoretical (molecular dynamics) and experimental techniques (mass spectrometry) to elucidate protein function.

Tivadar Orban's Genealogy

Tivadar Orban's Publications (11)