Trinna L Cuellar

Trinna L Cuellar, Ph.D.

  • Positions:
    research

    Molecular Biology

    Genentech, Inc. (South San Francisco, CA)

    Graduate Student - Ph.D.

    Biomedical Sciences

    University of California, San Francisco (San Francisco, CA)

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  • Advisor:

    Michael T McManus

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  • Degrees:
     
    Ph.D., Biomedical Sciences, University of California, San Francisco (San Francisco, CA)
     
    B.Sc., Biological Sciences, Drexel University (Philadelphia, PA)
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  • Past Advisors:
     
    Aleister J Saunders (as Lab Manager)
     
    Jeremy Lee (as Undergraduate Student)
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  • Research:
    RNAi/miRNAs, Neuroscience, Development, Notch signaling.

    Very broadly speaking, I am interested in the regulation of gene expression at the transcriptional/post-trascriptional level.

    The expression of our genes is wildly complex, and I think we are still at the tip of the iceberg of understanding the mechanisms for how this is achieved.

    I have had a fascination with small RNAs, since about 2001, when the Tuschl, Bartel and Ambros labs, discovered that hundreds of small RNAs exist in animal genomes and when I first learned about RNA interference by reading the seminal 1998 paper from Fire et al. It was shocking to me that these tiny RNAs remained under the radar for so long and, like many others, was intrigued by not only what they may be doing in our cells, but also the possibilities of engineering small RNAs as therapeutics by usurping the pathway.

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  • Other Experience:

    2002 Research Associate, Comparative Genomics Internship, GlaxoSmithKline

    2000-2001 Research Associate, Cancer Research Internship, GlaxoSmithKline

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  • Honors:

    2007 Keystone Symposia Scholarship

    2006-2007 Sandler Family/Genentech Inc. Fellow

    2005-2006 ARCS (Achievement Awards for Research Scientists) Fellow

    2005 NSF, Honorable Mention

Life Sciences
Communities:

Trinna Cuellar's Genealogy

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Trinna Cuellar's Publications (6)



Trinna Cuellar's Posters and Presentations (12)

  • Dicer loss in striatal neurons produces behavioral and neuroanatomical phenotypes in absence of neurodegeneration. (poster)

    Trinna L Cuellar

    Keystone Symposia: RNAi, MicroRNA, and Non-Coding RNA, Whistler, British Columbia, Canada; 03/2008
  • Development of a Mouse Model to Study Dicer Function in the Brain. (presentation)

    Trinna L Cuellar

    Keystone Symposia: MicroRNAs and siRNAs: Biological Functions and Mechanisms, Keystone, Colorado; 01/2007
  • Development and Characterization of a Mouse Model to Study Dicer Function in Post-mitotic Neurons. (presentation)

    Trinna L Cuellar

    Annual Diabetes Center Retreat, Point Reyes, CA; 10/2006
  • MicroRNAs on the Mind: Development and Characterization of a Mouse Model to Study Dicer Function in Post-Mitotic Neurons (poster)

    Trinna L Cuellar

    Annual UCSF Immunology Retreat, Asilomar, CA ; 10/2006
  • MicroRNAs on the Mind: Development and Characterization of a Mouse Model to Study Dicer Function in Post-Mitotic Neurons (poster)

    Trinna L Cuellar

    The Third Annual Bay Area Symposium on small modulatory RNAs, San Francisco, CA ; 06/2006
  • Interrogating Dicer Regulated Genes (presentation)

    Trinna L Cuellar

    Bay Area RNA Club, San Francisco, CA ; 01/2006
  • Something MicroRNAs (presentation)

    Trinna L Cuellar

    Annual UCSF Diabetes Center Retreat, Point Reyes, CA; 10/2005
  • Global Gene Expression Analysis in Conditional Mouse Dicer Knockout Cells. (poster)

    Trinna L Cuellar

    Cold Spring Harbor, RNAi conference, Cold Spring Harbor, NY; 09/2005
  • An Approach for Experimentally Determining Small RNA Targets (poster)

    Trinna L Cuellar

    The second annual bay area RNAi poster session in conjunction with the Hamilton symposium, San Francisco, CA ; 05/2005
  • The Involvement of the Insulin Signaling Pathway in APP Processing. (poster)

    Trinna L Cuellar

    The 9th international conference on Alzheimer’s disease and related disorders, Philadelphia, PA; 07/2004
  • Investigating the Role of the Insulin-Signaling Pathway in APP processing. (poster)

    Trinna L Cuellar

    The Drexel Institute of Protein Sciences Retreat, Philadelphia, PA; 05/2004
  • Stripe, a Developmental Switch Protein in Drosophila, which is Essential for Muscle Attachment. (poster)

    Trinna L Cuellar

    Drexel University Research Day, Philadelphia, PA; 05/2003

One Figure

One Figure for Trinna L Cuellar

Figure 1. Biogenesis of siRNAs and miRNAs.


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