Epernicus: Sung-Yun Pai, M.D.

Sung-Yun Pai, M.D.

Position:
Assistant Professor

Division of Hematology-Oncology

Dana-Farber Cancer Institute, Dept of Pediatric Oncology

Children's Hospital Boston (Boston, MA)
Degrees:

M.D., Harvard Medical School (Boston, MA)
Clinical Training:

Fellowship, Pediatric Hematology-Oncology, Dana-Farber Cancer Institute

Residency, Pediatrics, Children's Hospital Boston

Internship, Pediatrics, Children's Hospital Boston
Past Advisors:

I-Cheng Ho (as Post Doctoral Fellow)

Jeffrey M. Leiden (as Post Doctoral Fellow)

Barbara E. Bierer (as Medical Student)
Research:
T cell development and differentiation

Communities:

Sung-Yun Pai's Genealogy

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Sung-Yun Pai's Publications (18)

CDK inhibitor p18(INK4c) is a downstream target of GATA3 and restrains mammary luminal progenitor cell proliferation and tumorigenesis.
Pei XH, Bai F, Smith MD, Usary J, Fan C, Pai SY, Ho IC, Perou CM, Xiong Y

Cancer cell. 2009 May 5;15(5):389-401
Novel presentation of Omenn syndrome in association with aniridia.
Sheehan WJ, Delmonte OM, Miller DT, Roberts AE, Bonilla FA, Morra M, Giliani S, Pai SY, Notarangelo LD, Oettgen HC

The Journal of allergy and clinical immunology. 2009 Apr;123(4):966-9
GATA3 and the T-cell lineage: essential functions before and after T-helper-2-cell differentiation.
Ho IC, Tai TS, Pai SY

Nature reviews. Immunology. 2009 Feb;9(2):125-35
Allogeneic hematopoietic stem cell transplantation for X-linked ectodermal dysplasia and immunodeficiency: case report and review of outcomes.
Permaul P, Narla A, Hornick JL, Pai SY

Immunologic research. 2009;44(1-3):89-98
Allogeneic transplantation successfully corrects immune defects, but not susceptibility to colitis, in a patient with nuclear factor-kappaB essential modulator deficiency.
Pai SY, Levy O, Jabara HH, Glickman JN, Stoler-Barak L, Sachs J, Nurko S, Orange JS, Geha RS

The Journal of allergy and clinical immunology. 2008 Dec;122(6):1113-1118.e1
GATA-3 links tumor differentiation and dissemination in a luminal breast cancer model.
Kouros-Mehr H, Bechis SK, Slorach EM, Littlepage LE, Egeblad M, Ewald AJ, Pai SY, Ho IC, Werb Z

Cancer cell. 2008 Feb;13(2):141-52
Distinct structural requirements of GATA-3 for the regulation of thymocyte and Th2 cell differentiation.
Pai SY, Kang BY, Sabadini AM, Parisini E, Truitt ML, Ho IC

Journal of immunology (Baltimore, Md. : 1950). 2008 Jan 15;180(2):1050-9
GATA-3 - not just for Th2 cells anymore.
Ho IC, Pai SY

Cellular & molecular immunology. 2007 Feb;4(1):15-29
GATA-3 regulates the development and function of invariant NKT cells.
Kim PJ, Pai SY, Brigl M, Besra GS, Gumperz J, Ho IC

Journal of immunology (Baltimore, Md. : 1950). 2006 Nov 15;177(10):6650-9
Lipid defect underlies selective skin barrier impairment of an epidermal-specific deletion of Gata-3.
de Guzman Strong C, Wertz PW, Wang C, Yang F, Meltzer PS, Andl T, Millar SE, Ho IC, Pai SY, Segre JA

The Journal of cell biology. 2006 Nov 20;175(4):661-70
Stem cell transplantation for the Wiskott-Aldrich syndrome: a single-center experience confirms efficacy of matched unrelated donor transplantation.
Pai SY, DeMartiis D, Forino C, Cavagnini S, Lanfranchi A, Giliani S, Moratto D, Mazza C, Porta F, Imberti L, Notarangelo LD, Mazzolari E

Bone marrow transplantation. 2006 Nov;38(10):671-9
GATA-3 deficiency abrogates the development and maintenance of T helper type 2 cells.
Pai SY, Truitt ML, Ho IC

Proceedings of the National Academy of Sciences of the United States of America. 2004 Feb 17;101(7):1993-8
Critical roles for transcription factor GATA-3 in thymocyte development.
Pai SY, Truitt ML, Ting CN, Leiden JM, Glimcher LH, Ho IC

Immunity. 2003 Dec;19(6):863-75
c-Rel delivers a one-two punch in Th1 cell differentiation.
Pai SY, Ho IC

The Journal of clinical investigation. 2002 Sep;110(6):741-2
Measurement of Calcineurin Phosphatase Activity in Cell Extracts
Fruman DA, Pai SY, Klee CB, Burakoff SJ, Bierer BE

Methods. 1996 Apr;9(2):146-54
Characterization of a mutant calcineurin A alpha gene expressed by EL4 lymphoma cells.
Fruman DA, Pai SY, Burakoff SJ, Bierer BE

Molecular and cellular biology. 1995 Jul;15(7):3857-63
Inhibition of calcineurin phosphatase activity in adult bone marrow transplant patients treated with cyclosporine A.
Pai SY, Fruman DA, Leong T, Neuberg D, Rosano TG, McGarigle C, Antin JH, Bierer BE

Blood. 1994 Dec 1;84(11):3974-9
Cross-linking CD28 leads to activation of 70-kDa S6 kinase.
Pai SY, Calvo V, Wood M, Bierer BE

European journal of immunology. 1994 Oct;24(10):2364-8

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Sung-Yun Pai, M.D.

Assistant Professor

T cell development and differentiation

Sung-Yun Pai's Genealogy

Sung-Yun Pai's Publications (18)