Epernicus: Shyh-Chang Ng, A.B.

Shyh-Chang Ng, A.B.

(Ph.D. in progress)

Position:
Graduate Student - Ph.D.

Biological and Biomedical Sciences

Harvard Medical School (Boston, MA)
Advisors:
George Q. Daley, Lewis C. Cantley
Degrees:

Ph.D. (in progress), Harvard Medical School (Boston, MA)

A.B., Molecular Biology, Princeton University (Princeton, NJ)
Past Advisors:

Bing Lim (as Visiting Student)

Eric F. Wieschaus (as Undergraduate Student)
Research:
Regulation of Metabolism by the Lin28/let-7 pathway in Mammalian Stem and Progenitor Cells

Communities:

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Human pluripotent stem cells decouple respiration from energy production.
Shyh-Chang N, Zheng Y, Locasale JW, Cantley LC

The EMBO journal. 2011 Dec 14;30(24):4851-2
Conserved regulation of p53 network dosage by microRNA-125b occurs through evolving miRNA-target gene pairs.
Le MT, Shyh-Chang N, Khaw SL, Chin L, Teh C, Tay J, O'Day E, Korzh V, Yang H, Lal A, Lieberman J, Lodish HF, Lim B

PLoS genetics. 2011 Sep;7(9):e1002242
The Lin28/let-7 axis regulates glucose metabolism.
Zhu H, Shyh-Chang N, Segrè AV, Shinoda G, Shah SP, Einhorn WS, Takeuchi A, Engreitz JM, Hagan JP, Kharas MG, Urbach A, Thornton JE, Triboulet R, Gregory RI, Altshuler D, Daley GQ

Cell. 2011 Sep 30;147(1):81-94
Lin28a transgenic mice manifest size and puberty phenotypes identified in human genetic association studies.
Zhu H, Shah S, Shyh-Chang N, Shinoda G, Einhorn WS, Viswanathan SR, Takeuchi A, Grasemann C, Rinn JL, Lopez MF, Hirschhorn JN, Palmert MR, Daley GQ

Nature genetics. 2010 Jul;42(7):626-30
MicroRNA-125b is a novel negative regulator of p53.
Le MT, Teh C, Shyh-Chang N, Xie H, Zhou B, Korzh V, Lodish HF, Lim B

Genes & development. 2009 Apr 1;23(7):862-76

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