Molecular and Cellular Pharmacology
Zoology
University of Wisconsin-Madison (Madison, WI)
The processes of cytokinesis and single-cell wound healing both involve the highly orchestrated recruitment of small GTPases like RhoA and Cdc42 to drive formation of a constrictive ring of actomyosin anchored to the plasma membrane. Our lab uses the Xenopus laevis model system to investigate proteins regulating recruitment of Rho-family GTPases in a spatiotemporally-defined manner via confocal microscopy techniques. My current project involves investigation of the chromosomal passenger complex at the metaphase-anaphase transition. Additionally, I am developing an assay to identify novel signaling components of the cytokinetic and single-cell wound healing pathways.
2010 Course in Proteomics, Cold Spring Harbor Laboratory

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Kigar SL, Tien V, Parker L, Kron SJ
Eisenberg AH, Kigar SL, Mrksich M