Samantha g Zeitlin

Samantha g Zeitlin, Ph.D.

  • Position:
    Post Doctoral Fellow

    Cell Biology

    Ludwig Institute for Cancer Research (New York, NY)

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  • Advisor:

    Don W Cleveland

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  • Degrees:
     
    Ph.D., Molecular and Cellular Structure and Chemistry, The Scripps Research Institute (La Jolla, CA)
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  • Past Advisors:
     
    Jean Y Wang (as Post Doctoral Fellow)
     
    John W. Newport (as Post Doctoral Fellow)
     
    Kevin F Sullivan (as Graduate Student - Ph.D.)
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  • Research:
    I am testing the hypothesis that centromeres are specified by an endogenous DNA damage mechanism, similar to what happens during class switch recombination and somatic hypermutation at Ig regions in B cells to generate antibodies.

    I found that the centromeric histone H3 variant CENP-A is rapidly deposited at double-strand breaks induced in vivo by endonuclease cleavage, as well as sites of damage created using a pulsed multiphoton laser. I am using a multidisciplinary approach combining cell biology, biochemistry, and biophysical methods to examine whether a putative role for CENP-A in DNA repair explains the so-called "epigenetic" mechanism of centromere specification in metazoans.

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  • Other Experience:

    1992-1997 Research Assistant

Life Sciences
Communities:

Samantha Zeitlin's Genealogy

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Samantha Zeitlin's Publications (7)



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