Epernicus: Sumit Chakraborty, Ph.D.

Sumit Chakraborty, Ph.D.

Positions:
Post Doctoral Fellow

Microbiology & Immunology

Weill Cornell Medical College (New York, NY)

Post Doctoral Fellow

Chemistry

Massachusetts Institute of Technology (Cambridge, MA)
Advisor:
Joanne Stubbe
Degrees:

Ph.D., Biochemistry, Rutgers Newark University (Newark, NJ)

M.Sc., Chemistry, Indian Institute of Technology Kharagpur (Kharagpur, India)

B.Sc., Chemistry, Presidency College, Kolkata (Kolkata, India)
Past Advisors:

Frank Jordan (as Graduate Student - Ph.D.)
Research:
Mechanistic Enzymology

Communities:

Sumit Chakraborty's Genealogy

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Sumit Chakraborty's Publications (9)

Detection of covalent and noncovalent intermediates in the polymerization reaction catalyzed by a C149S class III polyhydroxybutyrate synthase.
Li P, Chakraborty S, Stubbe J

Biochemistry. 2009 Oct 6;48(39):9202-11
Reaction mechanisms of thiamin diphosphate enzymes: defining states of ionization and tautomerization of the cofactor at individual steps.
Nemeria NS, Chakraborty S, Balakrishnan A, Jordan F

The FEBS journal. 2009 May;276(9):2432-46
Snapshot of a reaction intermediate: analysis of benzoylformate decarboxylase in complex with a benzoylphosphonate inhibitor.
Brandt GS, Kneen MM, Chakraborty S, Baykal AT, Nemeria N, Yep A, Ruby DI, Petsko GA, Kenyon GL, McLeish MJ, Jordan F, Ringe D

Biochemistry. 2009 Apr 21;48(15):3247-57
Detection and time course of formation of major thiamin diphosphate-bound covalent intermediates derived from a chromophoric substrate analogue on benzoylformate decarboxylase.
Chakraborty S, Nemeria NS, Balakrishnan A, Brandt GS, Kneen MM, Yep A, McLeish MJ, Kenyon GL, Petsko GA, Ringe D, Jordan F

Biochemistry. 2009 Feb 10;48(5):981-94
Probing the Active Center of Benzaldehyde Lyase with Substitutions and the Pseudosubstrate Analogue Benzoylphosphonic Acid Methyl Ester.
Brandt GS, Nemeria N, Chakraborty S, McLeish MJ, Yep A, Kenyon GL, Petsko GA, Jordan F, Ringe D

Biochemistry. 2008 Jun 21
Mechanism of benzaldehyde lyase studied via thiamin diphosphate-bound intermediates and kinetic isotope effects.
Chakraborty S, Nemeria N, Yep A, McLeish MJ, Kenyon GL, Jordan F

Biochemistry. 2008 Mar 25;47(12):3800-9
The 1',4'-iminopyrimidine tautomer of thiamin diphosphate is poised for catalysis in asymmetric active centers on enzymes.
Nemeria N, Chakraborty S, Baykal A, Korotchkina LG, Patel MS, Jordan F

Proceedings of the National Academy of Sciences of the United States of America. 2007 Jan 2;104(1):78-82
Acetylphosphinate is the most potent mechanism-based substrate-like inhibitor of both the human and Escherichia coli pyruvate dehydrogenase components of the pyruvate dehydrogenase complex.
Nemeria NS, Korotchkina LG, Chakraborty S, Patel MS, Jordan F

Bioorganic chemistry. 2006 Dec;34(6):362-79
Synthesis with good enantiomeric excess of both enantiomers of alpha-ketols and acetolactates by two thiamin diphosphate-dependent decarboxylases.
Baykal A, Chakraborty S, Dodoo A, Jordan F

Bioorganic chemistry. 2006 Dec;34(6):380-93

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Sumit Chakraborty, Ph.D.

Post Doctoral Fellow

Post Doctoral Fellow

Mechanistic Enzymology

Sumit Chakraborty's Genealogy

Sumit Chakraborty's Publications (9)