Epernicus: Rafael G Silva, Ph.D.

Rafael G Silva, Ph.D.

Position:
Post Doctoral Associate

Biochemistry

Albert Einstein College of Medicine (Bronx, New York)
Advisor:
Vern L Schramm
Degrees:

Ph.D., Biochemistry, Federal University of Rio Grande do Sul (Porto Alegre, Brazil)

M.Sc., Biochemistry, Federal University of Rio Grande do Sul (Porto Alegre, Brazil)

B.Sc., Biology, Federal University of Rio Grande do Sul (Porto Alegre, Brazil)
Past Advisors:

Luiz A Basso (as Graduate Student - Ph.D.)

Luiz A Basso (as Graduate Student - Masters)

Diogenes S Santos (as Graduate Student - Masters)
Research:
Transition state analysis of ribosyl-transfer reactions

Communities:

Rafael Silva's Genealogy

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Rafael Silva's Publications (18)

Transition-State Analysis of Trypanosoma cruzi Uridine Phosphorylase-Catalyzed Arsenolysis of Uridine.
Silva RG, Vetticatt MJ, Merino EF, Cassera MB, Schramm VL

Journal of the American Chemical Society. 2011 Jun 3
Arsenate and phosphate as nucleophiles at the transition states of human purine nucleoside phosphorylase.
Silva RG, Hirschi JS, Ghanem M, Murkin AS, Schramm VL

Biochemistry. 2011 Apr 5;50(13):2701-9
Purine nucleoside phosphorylase activity and expression are upregulated in sites affected by periodontal disease.
Batista EL, Deves C, Ayub L, da Silva RG, Filho LC, Basso LA, Santos DS

Journal of periodontal research. 2010 Oct;45(5):664-71
Mycobacterium tuberculosis beta-ketoacyl-ACP reductase: alpha-secondary kinetic isotope effects and kinetic and equilibrium mechanisms of substrate binding.
Silva RG, Rosado LA, Santos DS, Basso LA

Archives of biochemistry and biophysics. 2008 Mar 1;471(1):1-10
Purine nucleoside phosphorylase: a potential target for the development of drugs to treat T-cell- and apicomplexan parasite-mediated diseases.
Silva RG, Nunes JE, Canduri F, Borges JC, Gava LM, Moreno FB, Basso LA, Santos DS

Current drug targets. 2007 Mar;8(3):413-22
Kinetic and chemical mechanisms of shikimate dehydrogenase from Mycobacterium tuberculosis.
Fonseca IO, Silva RG, Fernandes CL, de Souza ON, Basso LA, Santos DS

Archives of biochemistry and biophysics. 2007 Jan 15;457(2):123-33
Mycobacterium tuberculosis beta-ketoacyl-acyl carrier protein (ACP) reductase: kinetic and chemical mechanisms.
Silva RG, de Carvalho LP, Blanchard JS, Santos DS, Basso LA

Biochemistry. 2006 Oct 31;45(43):13064-73
Functional shikimate dehydrogenase from Mycobacterium tuberculosis H37Rv: purification and characterization.
Fonseca IO, Magalhães ML, Oliveira JS, Silva RG, Mendes MA, Palma MS, Santos DS, Basso LA

Protein expression and purification. 2006 Apr;46(2):429-37
Kinetics and crystal structure of human purine nucleoside phosphorylase in complex with 7-methyl-6-thio-guanosine.
Silva RG, Pereira JH, Canduri F, de Azevedo WF, Basso LA, Santos DS

Archives of biochemistry and biophysics. 2005 Oct 1;442(1):49-58
Structure of human PNP complexed with ligands.
Canduri F, Silva RG, dos Santos DM, Palma MS, Basso LA, Santos DS, de Azevedo WF

Acta crystallographica. Section D, Biological crystallography. 2005 Jul;61(Pt 7):856-62
Purine nucleoside phosphorylase activity in rat cerebrospinal fluid.
Silva RG, Santos DS, Basso LA, Oses JP, Wofchuk S, Portela LV, Souza DO

Neurochemical research. 2004 Oct;29(10):1831-5
Structures of human purine nucleoside phosphorylase complexed with inosine and ddI.
Canduri F, dos Santos DM, Silva RG, Mendes MA, Basso LA, Palma MS, de Azevedo WF, Santos DS

Biochemical and biophysical research communications. 2004 Jan 23;313(4):907-14
Crystal structure of human PNP complexed with guanine.
de Azevedo WF, Canduri F, dos Santos DM, Pereira JH, Bertacine Dias MV, Silva RG, Mendes MA, Basso LA, Palma MS, Santos DS

Biochemical and biophysical research communications. 2003 Dec 19;312(3):767-72
Docking and small angle X-ray scattering studies of purine nucleoside phosphorylase.
Filgueira de Azevedo W, dos Santos GC, dos Santos DM, Olivieri JR, Canduri F, Silva RG, Basso LA, Renard G, da Fonseca IO, Mendes MA, Palma MS, Santos DS

Biochemical and biophysical research communications. 2003 Oct 3;309(4):923-8
Structural basis for inhibition of human PNP by immucillin-H.
Filgueira de Azevedo W, Canduri F, Marangoni dos Santos D, Pereira JH, Dias MV, Silva RG, Mendes MA, Basso LA, Palma MS, Santos DS

Biochemical and biophysical research communications. 2003 Oct 3;309(4):917-22
Crystal structure of human purine nucleoside phosphorylase at 2.3A resolution.
de Azevedo WF, Canduri F, dos Santos DM, Silva RG, de Oliveira JS, de Carvalho LP, Basso LA, Mendes MA, Palma MS, Santos DS

Biochemical and biophysical research communications. 2003 Aug 29;308(3):545-52
Crystal structure of human purine nucleoside phosphorylase complexed with acyclovir.
dos Santos DM, Canduri F, Pereira JH, Vinicius Bertacine Dias M, Silva RG, Mendes MA, Palma MS, Basso LA, de Azevedo WF, Santos DS

Biochemical and biophysical research communications. 2003 Aug 29;308(3):553-9
Cloning, overexpression, and purification of functional human purine nucleoside phosphorylase.
Silva RG, Carvalho LP, Oliveira JS, Pinto CA, Mendes MA, Palma MS, Basso LA, Santos DS

Protein expression and purification. 2003 Jan;27(1):158-64

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Rafael G Silva, Ph.D.

Post Doctoral Associate

Transition state analysis of ribosyl-transfer reactions

Rafael Silva's Genealogy

Rafael Silva's Publications (18)