Biological Engineering
Electrical and Computer Engineering
University of Missouri (Columbia, MO)
Molecular recognition is an important aspect of any biosensor system. Due to increased stability in a variety of environmental conditions, molecular imprinted polymer (MIP) technology is an attractive alternative to biological-based recognition. In order to utilize MIPs in optical biosensor applications, an effective and durable sensor scheme must be developed, and a highly sensitive optical signal transduction mechanism must be deployed. The sensor scheme under investigation makes use of micron-scale polymer particles that may be molecularly imprinted for specific analyte capture. In addition, fluorescent doping of the polymer matrix gives the MIP the dual capability of analyte capture and optical signal transduction. In order to realize such a proposed sensor scheme, poly(methacrylic acid) has been utilized as the polymer material. Doping of the polymer layers with CdSe/ZnS-capped quantum dots functionalized with the methacrylic acid functional monomer has been achieved. The functionalized quantum dots are capable of direct cross-linking within the polymer matrix and show intense, stable fluorescence when examined using fluorescence microscopy.
2004-2006 Undergraduate Research Assistant
2003 Cancer Research Intern

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R Cody Stringer, Sheila A Grant, Shubhra Gangopadhyay
R Cody Stringer, Sheila A Grant, Shubhra Gangopadhyay
R Cody Stringer, Sheila A Grant, Susan Schommer, Daniel Hoehn
R Cody Stringer, Sheila A Grant, Susan Schommer
R Cody Stringer, Darcy Lichlyter, Carol Lorenzen, and Sheila A Grant