Epernicus: Richard A Isbrucker, Ph.D.

Richard A Isbrucker, Ph.D.

Position:
Senior Research Scientist

Center for Biologics Research

Health Canada (Canada)
Degrees:

Ph.D., Pharmacology, Dalhousie University (Halifax, Canada)
Past Advisors:
Research:

Communities:

Richard Isbrucker's Genealogy

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Richard Isbrucker's Publications (17)

Risk and safety assessment on the consumption of Licorice root (Glycyrrhiza sp.), its extract and powder as a food ingredient, with emphasis on the pharmacology and toxicology of glycyrrhizin.
Isbrucker RA, Burdock GA

Regulatory toxicology and pharmacology : RTP. 2006 Dec;46(3):167-92
Safety studies on epigallocatechin gallate (EGCG) preparations. Part 1: genotoxicity.
Isbrucker RA, Bausch J, Edwards JA, Wolz E

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2006 May;44(5):626-35
Safety studies on epigallocatechin gallate (EGCG) preparations. Part 2: dermal, acute and short-term toxicity studies.
Isbrucker RA, Edwards JA, Wolz E, Davidovich A, Bausch J

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2006 May;44(5):636-50
Safety studies on epigallocatechin gallate (EGCG) preparations. Part 3: teratogenicity and reproductive toxicity studies in rats.
Isbrucker RA, Edwards JA, Wolz E, Davidovich A, Bausch J

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2006 May;44(5):651-61
Plakolide A, a new gamma-lactone from the marine sponge Plakortis sp.
Gunasekera SP, Isbrucker RA, Longley RE, Wright AE, Pomponi SA, Reed JK

Journal of natural products. 2004 Jan;67(1):110-1
Tubulin polymerizing activity of dictyostatin-1, a polyketide of marine sponge origin.
Isbrucker RA, Cummins J, Pomponi SA, Longley RE, Wright AE

Biochemical pharmacology. 2003 Jul 1;66(1):75-82
Semisynthetic analogues of the microtubule-stabilizing agent discodermolide: preparation and biological activity.
Gunasekera SP, Longley RE, Isbrucker RA

Journal of natural products. 2002 Dec;65(12):1830-7
Five new discodermolide analogues from the marine sponge Discodermia species.
Gunasekera SP, Paul GK, Longley RE, Isbrucker RA, Pomponi SA

Journal of natural products. 2002 Nov;65(11):1643-8
Structure-activity relationship studies of discodermolide and its semisynthetic acetylated analogs on microtubule function and cytotoxicity.
Isbrucker RA, Gunasekera SP, Longley RE

Cancer chemotherapy and pharmacology. 2001 Jul;48(1):29-36
Acetylated analogues of the microtubule-stabilizing agent discodermolide: preparation and biological activity.
Gunasekera SP, Longley RE, Isbrucker RA

Journal of natural products. 2001 Feb;64(2):171-4
The inhibitory effect of ursodeoxycholic acid and pentoxifylline on platelet derived growth factor-stimulated proliferation is distinct from an effect by cyclic AMP.
Peterson TC, Slysz G, Isbrucker R

Immunopharmacology. 1998 Jun;39(3):181-91
Platelet-derived growth factor and pentoxifylline modulation of collagen synthesis in myofibroblasts.
Isbrucker RA, Peterson TC

Toxicology and applied pharmacology. 1998 Mar;149(1):120-6
Assessment of arylamine N-acetyltransferase (NAT1) activity in mononuclear leukocytes of cystic fibrosis patients.
Cribb AE, Tsui B, Isbrucker R, Michael RT, Gillespie CT, Brown-Bonomo J, Barrett P, Levatte T, Renton KW

British journal of clinical pharmacology. 1995 Jan;39(1):85-9
Acetylator phenotyping: the urinary caffeine metabolite ratio in slow acetylators correlates with a marker of systemic NAT1 activity.
Cribb AE, Isbrucker R, Levatte T, Tsui B, Gillespie CT, Renton KW

Pharmacogenetics. 1994 Jun;4(3):166-70
In vitro effect of platelet-derived growth factor on fibroproliferation and effect of cytokine antagonists.
Peterson TC, Isbrucker RA, Hooper ML

Immunopharmacology. 1994 Nov-Dec;28(3):259-70
Fibroproliferation in liver disease: role of monocyte factors.
Peterson TC, Isbrucker RA

Hepatology (Baltimore, Md.). 1992 Feb;15(2):191-7
Adenosine mediates calcium-induced antinociception and potentiation of noradrenergic antinociception in the spinal cord.
Sawynok J, Reid A, Isbrucker R

Brain research. 1990 Aug 6;524(2):187-95

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Richard A Isbrucker, Ph.D.

Senior Research Scientist

Richard Isbrucker's Genealogy

Richard Isbrucker's Publications (17)