Epernicus: Philip T Liu, Ph.D.

Philip T Liu, Ph.D.

Position:
Post Doctoral Fellow

Medicine

Division of Dermatology

University of California, Los Angeles (Los Angeles, CA)
Advisor:
Robert Modlin
Degrees:

Ph.D., Immunology, University of California, Los Angeles (Los Angeles, CA)
Past Advisors:
Research:
The role of vitamin D in the innate immune response to intracellular mycobacteria.

My research focuses on the human innate immune response against mycobacterial infections. In particular I am interested in the direct antimicrobial effectors and the factors that regulate their activity and function.
Other Experience:
2008-present 1. K30 Graduate Training Program in Translational Research Track II Fellow
Honors:
2009 1. Certificate of Excellence in Postdoctoral Research in Biochemistry and Molecular Biology

2008 1. Chancellor’s Award for Post-doctoral Research, UCLA

2007 2. Advances in Acne Research Award, SID

2004 3. AAD Annual Meeting, 4th place poster

1999 4. Howard Hughes Medical Institute Summer Honors Research Award

Communities:

Philip Liu's Genealogy

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Philip Liu's Publications (22)

T-cell cytokines differentially control human monocyte antimicrobial responses by regulating vitamin D metabolism.
Edfeldt K, Liu PT, Chun R, Fabri M, Schenk M, Wheelwright M, Keegan C, Krutzik SR, Adams JS, Hewison M, Modlin RL

Proceedings of the National Academy of Sciences of the United States of America. 2010 Dec 28;107(52):22593-8
1alpha,25-dihydroxyvitamin D<formula>_{3}</formula> Interacts with Curcuminoids to Stimulate Amyloid-beta Clearance by Macrophages of Alzheimer's Disease Patients.
Masoumi A, Goldenson B, Ghirmai S, Avagyan H, Zaghi J, Abel K, Zheng X, Espinosa-Jeffrey A, Mahanian M, Liu PT, Hewison M, Mizwicki M, Cashman J, Fiala M

Journal of Alzheimer's disease : JAD. 2009 May 11
Vitamin d-directed rheostatic regulation of monocyte antibacterial responses.
Adams JS, Ren S, Liu PT, Chun RF, Lagishetty V, Gombart AF, Borregaard N, Modlin RL, Hewison M

Journal of immunology (Baltimore, Md. : 1950). 2009 Apr 1;182(7):4289-95
Immune blood biomarkers of Alzheimer disease patients.
Avagyan H, Goldenson B, Tse E, Masoumi A, Porter V, Wiedau-Pazos M, Sayre J, Ong R, Mahanian M, Koo P, Bae S, Micic M, Liu PT, Rosenthal MJ, Fiala M

Journal of neuroimmunology. 2009 Mar 27
Convergence of IL-1beta and VDR activation pathways in human TLR2/1-induced antimicrobial responses.
Liu PT, Schenk M, Walker VP, Dempsey PW, Kanchanapoomi M, Wheelwright M, Vazirnia A, Zhang X, Steinmeyer A, Zügel U, Hollis BW, Cheng G, Modlin RL

PLoS ONE. 2009;4(6):e5810
All-trans retinoic acid shifts Propionibacterium acnes-induced matrix degradation expression profile toward matrix preservation in human monocytes.
Jalian HR, Liu PT, Kanchanapoomi M, Phan JN, Legaspi AJ, Kim J

The Journal of investigative dermatology. 2008 Dec;128(12):2777-82
IL-15 links TLR2/1-induced macrophage differentiation to the vitamin D-dependent antimicrobial pathway.
Krutzik SR, Hewison M, Liu PT, Robles JA, Stenger S, Adams JS, Modlin RL

Journal of immunology (Baltimore, Md. : 1950). 2008 Nov 15;181(10):7115-20
Human macrophage host defense against Mycobacterium tuberculosis.
Liu PT, Modlin RL

Current opinion in immunology. 2008 Aug;20(4):371-6
CD209(+) macrophages mediate host defense against Propionibacterium acnes.
Liu PT, Phan J, Tang D, Kanchanapoomi M, Hall B, Krutzik SR, Kim J

Journal of immunology (Baltimore, Md. : 1950). 2008 Apr 1;180(7):4919-23
Vitamin D in defense of the human immune response.
Adams JS, Liu PT, Chun R, Modlin RL, Hewison M

Annals of the New York Academy of Sciences. 2007 Nov;1117:94-105
Cutting edge: vitamin D-mediated human antimicrobial activity against Mycobacterium tuberculosis is dependent on the induction of cathelicidin.
Liu PT, Stenger S, Tang DH, Modlin RL

Journal of immunology (Baltimore, Md. : 1950). 2007 Aug 15;179(4):2060-3
Innate immunity and transcription of MGAT-III and Toll-like receptors in Alzheimer's disease patients are improved by bisdemethoxycurcumin.
Fiala M, Liu PT, Espinosa-Jeffrey A, Rosenthal MJ, Bernard G, Ringman JM, Sayre J, Zhang L, Zaghi J, Dejbakhsh S, Chiang B, Hui J, Mahanian M, Baghaee A, Hong P, Cashman J

Proceedings of the National Academy of Sciences of the United States of America. 2007 Jul 31;104(31):12849-54
Injury enhances TLR2 function and antimicrobial peptide expression through a vitamin D-dependent mechanism.
Schauber J, Dorschner RA, Coda AB, Büchau AS, Liu PT, Kiken D, Helfrich YR, Kang S, Elalieh HZ, Steinmeyer A, Zügel U, Bikle DD, Modlin RL, Gallo RL

The Journal of clinical investigation. 2007 Mar;117(3):803-11
Therapeutic implications of the TLR and VDR partnership.
Liu PT, Krutzik SR, Modlin RL

Trends in molecular medicine. 2007 Mar;13(3):117-24
TLR activation of Langerhans cell-like dendritic cells triggers an antiviral immune response.
Renn CN, Sanchez DJ, Ochoa MT, Legaspi AJ, Oh CK, Liu PT, Krutzik SR, Sieling PA, Cheng G, Modlin RL

Journal of immunology (Baltimore, Md. : 1950). 2006 Jul 1;177(1):298-305
Toll-like receptor triggering of a vitamin D-mediated human antimicrobial response.
Liu PT, Stenger S, Li H, Wenzel L, Tan BH, Krutzik SR, Ochoa MT, Schauber J, Wu K, Meinken C, Kamen DL, Wagner M, Bals R, Steinmeyer A, Zügel U, Gallo RL, Eisenberg D, Hewison M, Hollis BW, Adams JS, Bloom BR, Modlin RL

Science (New York, N.Y.). 2006 Mar 24;311(5768):1770-3
TLR activation triggers the rapid differentiation of monocytes into macrophages and dendritic cells.
Krutzik SR, Tan B, Li H, Ochoa MT, Liu PT, Sharfstein SE, Graeber TG, Sieling PA, Liu YJ, Rea TH, Bloom BR, Modlin RL

Nature medicine. 2005 Jun;11(6):653-60
TGF-alpha regulates TLR expression and function on epidermal keratinocytes.
Miller LS, Sørensen OE, Liu PT, Jalian HR, Eshtiaghpour D, Behmanesh BE, Chung W, Starner TD, Kim J, Sieling PA, Ganz T, Modlin RL

Journal of immunology (Baltimore, Md. : 1950). 2005 May 15;174(10):6137-43
Cutting edge: all-trans retinoic acid down-regulates TLR2 expression and function.
Liu PT, Krutzik SR, Kim J, Modlin RL

Journal of immunology (Baltimore, Md. : 1950). 2005 Mar 1;174(5):2467-70
Toll-like receptors induce a phagocytic gene program through p38.
Doyle SE, O'Connell RM, Miranda GA, Vaidya SA, Chow EK, Liu PT, Suzuki S, Suzuki N, Modlin RL, Yeh WC, Lane TF, Cheng G

The Journal of experimental medicine. 2004 Jan 5;199(1):81-90
Activation and regulation of Toll-like receptors 2 and 1 in human leprosy.
Krutzik SR, Ochoa MT, Sieling PA, Uematsu S, Ng YW, Legaspi A, Liu PT, Cole ST, Godowski PJ, Maeda Y, Sarno EN, Norgard MV, Brennan PJ, Akira S, Rea TH, Modlin RL

Nature medicine. 2003 May;9(5):525-32
High-yield expression and purification of human interferon alpha-1 in Pichia pastoris.
Liu PT, Ta TV, Villarete LH

Protein expression and purification. 2001 Aug;22(3):381-7

One Figure

Model of TLR-induced VDR-dependent antimicrobial pathway.

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Philip T Liu, Ph.D.

Post Doctoral Fellow

The role of vitamin D in the innate immune response to intracellular mycobacteria.

Philip Liu's Genealogy

Philip Liu's Publications (22)

One Figure