Epernicus: Patrick M Loerch, Ph.D.

Patrick M Loerch, Ph.D.

Position:
Director, Health Informatics

Research Informatics

Merck Research Laboratories (Boston, MA)
Degrees:

Ph.D., Biostatistics, Harvard University (Cambridge, MA)

M.A., Biostatistics, Harvard University (Cambridge, MA)

B.S., Biochemistry, Washington State University (Pullman, WA)
Past Advisors:

Bruce A Yankner (as Graduate Student - Ph.D.)
Research:
Application and Integration of Biological, Computational and Statistical Approaches to Characterize Complex Disease Pathways and Identify Opportunities for Pharmacological Interventions

Communities:

Patrick Loerch's Genealogy

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Patrick Loerch's Publications (7)

Digital transcriptome profiling using selective hexamer priming for cDNA synthesis.
Armour CD, Castle JC, Chen R, Babak T, Loerch P, Jackson S, Shah JK, Dey J, Rohl CA, Johnson JM, Raymond CK

Nature methods. 2009 Sep;6(9):647-9
SIRT1 redistribution on chromatin promotes genomic stability but alters gene expression during aging.
Oberdoerffer P, Michan S, McVay M, Mostoslavsky R, Vann J, Park SK, Hartlerode A, Stegmuller J, Hafner A, Loerch P, Wright SM, Mills KD, Bonni A, Yankner BA, Scully R, Prolla TA, Alt FW, Sinclair DA

Cell. 2008 Nov 28;135(5):907-18
Evolution of the aging brain transcriptome and synaptic regulation.
Loerch PM, Lu T, Dakin KA, Vann JM, Isaacs A, Geula C, Wang J, Pan Y, Gabuzda DH, Li C, Prolla TA, Yankner BA

PloS one. 2008;3(10):e3329
The aging brain.
Yankner BA, Lu T, Loerch P

Annual review of pathology. 2008;3:41-66
Genome-wide survey of human alternative pre-mRNA splicing with exon junction microarrays.
Johnson JM, Castle J, Garrett-Engele P, Kan Z, Loerch PM, Armour CD, Santos R, Schadt EE, Stoughton R, Shoemaker DD

Science (New York, N.Y.). 2003 Dec 19;302(5653):2141-4
Optimization of oligonucleotide arrays and RNA amplification protocols for analysis of transcript structure and alternative splicing.
Castle J, Garrett-Engele P, Armour CD, Duenwald SJ, Loerch PM, Meyer MR, Schadt EE, Stoughton R, Parrish ML, Shoemaker DD, Johnson JM

Genome biology. 2003;4(10):R66
Experimental annotation of the human genome using microarray technology.
Shoemaker DD, Schadt EE, Armour CD, He YD, Garrett-Engele P, McDonagh PD, Loerch PM, Leonardson A, Lum PY, Cavet G, Wu LF, Altschuler SJ, Edwards S, King J, Tsang JS, Schimmack G, Schelter JM, Koch J, Ziman M, Marton MJ, Li B, Cundiff P, Ward T, Castle J, Krolewski M, Meyer MR, Mao M, Burchard J, Kidd MJ, Dai H, Phillips JW, Linsley PS, Stoughton R, Scherer S, Boguski MS

Nature. 2001 Feb 15;409(6822):922-7

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Patrick M Loerch, Ph.D.

Director, Health Informatics

Application and Integration of Biological, Computational and Statistical Approaches to Characterize Complex Disease Pathways and Identify Opportunities for Pharmacological Interventions

Patrick Loerch's Genealogy

Patrick Loerch's Publications (7)