Epernicus: Patricia L. Clark

Patricia L. Clark

Position:
Associate Professor

Chemistry & Biochemistry

University of Notre Dame (South Bend, IN)
Degrees:
Past Advisors:

Jonathan A. King (as Post Doctoral Fellow)

Lila M Gierasch (as Graduate Student - Ph.D.)

Martha S. Briggs (as Undergraduate Student)
Research:
Protein folding in the cellular environment, with a special emphasis on vectorial folding of polypeptide chains as they emerge from the ribosome, or cross a membrane barrier.

Communities:

Patricia Clark's Genealogy

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Patricia Clark's Publications (13)

Cotranslational Folding Promotes beta-Helix Formation and Avoids Aggregation In Vivo.
Evans MS, Sander IM, Clark PL

Journal of molecular biology. 2008 Jul 22
A conserved stable core structure in the passenger domain beta-helix of autotransporter virulence proteins.
Renn JP, Clark PL

Biopolymers. 2008 May;89(5):420-7
Pertactin beta-helix folding mechanism suggests common themes for the secretion and folding of autotransporter proteins.
Junker M, Schuster CC, McDonnell AV, Sorg KA, Finn MC, Berger B, Clark PL

Proceedings of the National Academy of Sciences of the United States of America. 2006 Mar 28;103(13):4918-23
Homogeneous stalled ribosome nascent chain complexes produced in vivo or in vitro.
Evans MS, Ugrinov KG, Frese MA, Clark PL

Nature methods. 2005 Oct;2(10):757-62
Monoclonal antibody epitope mapping describes tailspike beta-helix folding and aggregation intermediates.
Jain M, Evans MS, King J, Clark PL

The Journal of biological chemistry. 2005 Jun 17;280(24):23032-40
Conformations of co-translational folding intermediates.
Evans MS, Clarke TF, Clark PL

Protein and peptide letters. 2005 Feb;12(2):189-95
Protein folding in the cell: reshaping the folding funnel.
Clark PL

Trends in biochemical sciences. 2004 Oct;29(10):527-34
Characterization of the protrimer intermediate in the folding pathway of the interdigitated beta-helix tailspike protein.
Benton CB, King J, Clark PL

Biochemistry. 2002 Apr 23;41(16):5093-103
A newly synthesized, ribosome-bound polypeptide chain adopts conformations dissimilar from early in vitro refolding intermediates.
Clark PL, King J

The Journal of biological chemistry. 2001 Jul 6;276(27):25411-20
Distinct cysteine sulfhydryl environments detected by analysis of Raman S-hh markers of Cys-->Ser mutant proteins.
Raso SW, Clark PL, Haase-Pettingell C, King J, Thomas GJ

Journal of molecular biology. 2001 Mar 30;307(3):899-911
Probing the folding pathway of a beta-clam protein with single-tryptophan constructs.
Clark PL, Weston BF, Gierasch LM

Folding & design. 1998;3(5):401-12
Cavity formation before stable hydrogen bonding in the folding of a beta-clam protein.
Clark PL, Liu ZP, Rizo J, Gierasch LM

Nature structural biology. 1997 Nov;4(11):883-6
Intrinsic tryptophans of CRABPI as probes of structure and folding.
Clark PL, Liu ZP, Zhang J, Gierasch LM

Protein science : a publication of the Protein Society. 1996 Jun;5(6):1108-17

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Patricia L. Clark

Associate Professor

Protein folding in the cellular environment, with a special emphasis on vectorial folding of polypeptide chains as they emerge from the ribosome, or cross a membrane barrier.

Patricia Clark's Genealogy

Patricia Clark's Publications (13)