Paul H Huang, Ph.D.
- Position:
Team Leader
Protein Networks Team
Division of Cancer Biology
Institute of Cancer Research (London, UK)
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Degrees:
Ph.D., Biological Engineering, Massachusetts Institute of Technology (Cambridge, MA)B.Sc., Biotechnology, Imperial College London (London, United Kingdom)
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Past Advisors:
Forest M White (as Post Doctoral Fellow)Forest M White (as Graduate Student - Ph.D.)
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Research:
Oncogenic Signaling Networks
Our focus is to elucidate the protein phosphorylation networks that regulate complex cancer phenotypes such as chemoresistance and tumour progression. The primary tool that the lab employs to map signaling networks is mass spectrometry – a powerful technique that allows for the unbiased identification and quantification of well-established and novel phosphorylation sites (phosphoproteomics) with exquisite sensitivity over a large dynamic range. Through the use of biochemical techniques and phosphoproteomics, we aim to:
1. Understand how signaling networks adapt to changes in their microenvironment and in response to chemotherapy
2. Determine the mechanistic basis of signal integration downstream of multiple extracellular cues
3. Explore how network information can be harnessed to develop novel therapeutic strategies for cancer
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Other Experience:
2010-present Editorial Board Member, American Journal of Cancer Research
2007-2008 Lecturer, Cold Spring Harbor Laboratory Proteomics Course
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Honors:
2009-present Sir Henry Wellcome Fellowship
2008 AACR-Merck Scholar-in-Training Award
2007 Myriam Marcelle Znaty Research Prize
2007 AACR-Bristol-Myers Squibb Oncology Scholar-in-Training Award
2007 Keystone Symposia Scholarship
2006 Aspen Cancer Conference Scientific Fellow
2005-2008 Integrative Cancer Biology Program Fellow
2004 Governors Prize in Biochemistry
Paul Huang's Genealogy
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