Epernicus: Sumit Prakash, Ph.D.

Sumit Prakash, Ph.D.

Position:
Post Doctoral Fellow

Cellular and Molecular Pharmacology

University of California, San Francisco (San Francisco, CA)
Advisor:
Jack Taunton
Degrees:

Ph.D., Biochemistry, Northwestern University (Evanston, IL)

M.S., Biotechnology and Biophysics, University of Pune (Pune, India)

B.S., Zoology, University of Delhi (Delhi, India)
Past Advisors:

Andreas Matouschek (as Post Doctoral Fellow)

Andreas Matouschek (as Graduate Student - Ph.D.)

V. Sitaramam (as Graduate Student - Masters)
Research:
The role of the dynamic actin cytoskeleton in signal transduction and cancer

Communities:

Sumit Prakash's Genealogy

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Sumit Prakash's Publications (11)

Rad23 escapes degradation because it lacks a proteasome initiation region.
Fishbain S, Prakash S, Herrig A, Elsasser S, Matouschek A

Nature communications. 2011 Feb;2:192
Defining the geometry of the two-component proteasome degron.
Inobe T, Fishbain S, Prakash S, Matouschek A

Nature chemical biology. 2011 Jan 30
ATP-dependent proteases differ substantially in their ability to unfold globular proteins.
Koodathingal P, Jaffe NE, Kraut DA, Prakash S, Fishbain S, Herman C, Matouschek A

The Journal of biological chemistry. 2009 Jul 10;284(28):18674-84
Substrate selection by the proteasome during degradation of protein complexes.
Prakash S, Inobe T, Hatch AJ, Matouschek A

Nature chemical biology. 2009 Jan;5(1):29-36
Controlling a single protein in a nanopore through electrostatic traps.
Mohammad MM, Prakash S, Matouschek A, Movileanu L

Journal of the American Chemical Society. 2008 Mar 26;130(12):4081-8
To degrade or release: ubiquitin-chain remodeling.
Kraut DA, Prakash S, Matouschek A

Trends in cell biology. 2007 Sep;17(9):419-21
Protein unfolding in the cell.
Prakash S, Matouschek A

Trends in biochemical sciences. 2004 Nov;29(11):593-600
An unstructured initiation site is required for efficient proteasome-mediated degradation.
Prakash S, Tian L, Ratliff KS, Lehotzky RE, Matouschek A

Nature structural & molecular biology. 2004 Sep;11(9):830-7
Lack of a robust unfoldase activity confers a unique level of substrate specificity to the universal AAA protease FtsH.
Herman C, Prakash S, Lu CZ, Matouschek A, Gross CA

Molecular cell. 2003 Mar;11(3):659-69
Concurrent translocation of multiple polypeptide chains through the proteasomal degradation channel.
Lee C, Prakash S, Matouschek A

The Journal of biological chemistry. 2002 Sep 20;277(38):34760-5
ATP-dependent proteases degrade their substrates by processively unraveling them from the degradation signal.
Lee C, Schwartz MP, Prakash S, Iwakura M, Matouschek A

Molecular cell. 2001 Mar;7(3):627-37

One Figure

Substrate selection by the proteasome during degradation of protein complexes

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Sumit Prakash, Ph.D.

Post Doctoral Fellow

The role of the dynamic actin cytoskeleton in signal transduction and cancer

Sumit Prakash's Genealogy

Sumit Prakash's Publications (11)

One Figure