Epernicus: SHARMISTHA SINHA, Ph.D.

SHARMISTHA SINHA, Ph.D.

Position:
Post Doctoral Fellow

Department of Biochemistry, Biophysics and Molecular Biology

Iowa State University (Ames, IA)
Advisor:
Thomas A Bobik
Degrees:

Ph.D., Biophysics, Indian Institute of Science (Bangalore, India)
Past Advisors:

Gal Bitan (as Post Doctoral Fellow)

Avadhesha Surolia (as Post Doctoral Fellow)

Avadhesha Surolia (as Graduate Student - Ph.D.)
Research:
Protein Aggregation and Disease/ Engineering Bacterial Microcompartments
Other Experience:
2006-present Post doctoral Fellow
Honors:
2008 INSA, Young Scientist Medal

Communities:

SHARMISTHA SINHA's Genealogy

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SHARMISTHA SINHA's Publications (30)

A Novel "Molecular Tweezer" Inhibitor of α-Synuclein Neurotoxicity in Vitro and in Vivo.
Prabhudesai S, Sinha S, Attar A, Kotagiri A, Fitzmaurice AG, Lakshmanan R, Ivanova MI, Loo JA, Klärner FG, Schrader T, Stahl M, Bitan G, Bronstein JM

Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics. 2012 Feb 29
The PduM protein is a structural component of the microcompartments involved in coenzyme B12-dependent 1,2-propanediol degradation by Salmonella.
Sinha S, Cheng S, Fan C, Bobik TA

Journal of bacteriology. 2012 Feb 17
Lysine-specific molecular tweezers are broad-spectrum inhibitors of assembly and toxicity of amyloid proteins.
Sinha S, Lopes DH, Du Z, Pang ES, Shanmugam A, Lomakin A, Talbiersky PM, Tennstaedt A, McDaniel K, Bakshi R, Kuo PY, Ehrmann M, Benedek GB, Loo JA, Klärner FG, Schrader T, Wang C, Bitan G

Journal of the American Chemical Society. 2011 Oct 26;133(42):16958-69
Genetic analysis of the protein shell of the microcompartments involved in coenzyme B12-dependent 1,2-propanediol degradation by Salmonella.
Cheng S, Sinha S, Fan C, Liu Y, Bobik TA

Journal of bacteriology. 2011 Mar;193(6):1385-92
Rational design of β-sheet ligands against Aβ42-induced toxicity.
Hochdörffer K, März-Berberich J, Nagel-Steger L, Epple M, Meyer-Zaika W, Horn AH, Sticht H, Sinha S, Bitan G, Schrader T

Journal of the American Chemical Society. 2011 Mar 30;133(12):4348-58
Probing into the role of conserved N-glycosylation sites in the Tyrosinase glycoprotein family.
Gupta G, Sinha S, Mitra N, Surolia A

Glycoconjugate journal. 2009 Aug;26(6):691-5
Amyloids and Protein Aggregation—Analytical Methods
Huiyuan Li, Farid Rahimi, Kazuma Murakami, SHARMISTHA SINHA, Panchanan Maiti, Gal Bitan

Encyclopedia of Analytical Chemistry. 2009
Unfolding energetics and stability of banana lectin.
Gupta G, Sinha S, Surolia A

Proteins. 2008 Aug;72(2):754-60
Form and dimensions of aggregates dictate cytotoxicities of Danish dementia peptides.
Surolia I, Sarkar DP, Sinha S

Biochemical and biophysical research communications. 2008 Jul 18;372(1):62-6
Fibrillogenesis in ADan peptides is inhibited by biphenyl ethers.
Surolia I, Chhibber M, Sarkar DP, Sinha S

Biochemical and biophysical research communications. 2008 Jun 13;370(4):681-6
SPR and ITC determination of the kinetics and the thermodynamics of bivalent versus monovalent sugar ligand-lectin interactions.
Murthy BN, Sinha S, Surolia A, Indi SS, Jayaraman N

Glycoconjugate journal. 2008 May;25(4):313-21
Deuterium oxide stabilizes conformation of tubulin:a biophysical and biochemical study.
Das A, Sinha S, Acharya BR, Paul P, Bhattacharyya B, Chakrabarti G

BMB reports. 2008 Jan 31;41(1):62-7
Concurrence of Danish dementia and cataract: insights from the interactions of dementia associated peptides with eye lens alpha-crystallin.
Surolia I, Sinha S, Sarkar DP, Reddy PY, Reddy GB, Surolia A

PloS one. 2008;3(8):e2927
Design of mechanism-based inhibitors of transthyretin amyloidosis: studies with biphenyl ethers and new structural templates.
Gupta S, Chhibber M, Sinha S, Surolia A

Journal of medicinal chemistry. 2007 Nov 15;50(23):5589-99
Subunit assembly of plant lectins.
Sinha S, Gupta G, Vijayan M, Surolia A

Current opinion in structural biology. 2007 Oct;17(5):498-505
Conformational stability and thermodynamic characterization of homotetrameric Plasmodium falciparum beta-ketoacyl-ACP reductase.
Karmodiya K, Sajad S, Sinha S, Maity K, Suguna K, Surolia N

IUBMB life. 2007 Jul;59(7):441-9
Isothermal unfolding studies on the apo and holo forms of Plasmodium falciparum acyl carrier protein. Role of the 4'-phosphopantetheine group in the stability of the holo form of Plasmodium falciparum acyl carrier protein.
Modak R, Sinha S, Surolia N

The FEBS journal. 2007 Jul;274(13):3313-26
Napin from Brassica juncea: thermodynamic and structural analysis of stability.
Jyothi TC, Sinha S, Singh SA, Surolia A, Appu Rao AG

Biochimica et biophysica acta. 2007 Jul;1774(7):907-19
Attributes of glycosylation in the establishment of the unfolding pathway of soybean agglutinin.
Sinha S, Surolia A

Biophysical journal. 2007 Jan 1;92(1):208-16
Sugar-quantum dot conjugates for a selective and sensitive detection of lectins.
Babu P, Sinha S, Surolia A

Bioconjugate chemistry. 2007 Jan-Feb;18(1):146-51
Isothermal titration calorimetric study defines the substrate binding residues of calreticulin.
Gopalakrishnapai J, Gupta G, Karthikeyan T, Sinha S, Kandiah E, Gemma E, Oscarson S, Surolia A

Biochemical and biophysical research communications. 2006 Dec 8;351(1):14-20
Hierarchy and the mechanism of fibril formation in ADan peptides.
Surolia I, Reddy GB, Sinha S

Journal of neurochemistry. 2006 Oct;99(2):537-48
Broad substrate stereospecificity of the Mycobacterium tuberculosis 7-keto-8-aminopelargonic acid synthase: Spectroscopic and kinetic studies.
Bhor VM, Dev S, Vasanthakumar GR, Kumar P, Sinha S, Surolia A

The Journal of biological chemistry. 2006 Sep 1;281(35):25076-88
Thermodynamic analysis of three state denaturation of Peanut Agglutinin.
Dev S, K ND, Sinha S, Surolia A

IUBMB life. 2006 Sep;58(9):549-55
N-linked oligosaccharides as outfitters for glycoprotein folding, form and function.
Mitra N, Sinha S, Ramya TN, Surolia A

Trends in biochemical sciences. 2006 Mar;31(3):156-63

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SHARMISTHA SINHA's Posters and Presentations (2)

RATIONAL SELECTION OF SMALL MOLECULES AS INHIBITORS OF AMYLOID β-PROTEIN ASSEMBLY AND TOXICITY (poster)
SHARMISTHA SINHA

Protein Society Meeting, Boston; 07/2009
Role of Glycosylation adn oligomerization on Soybean Agglutinin stability (poster)
SHARMISTHA SINHA

Glyco XVIII, Florence, Italy,; 09/2005

One Figure

Bacterial Micro-compartments from Salmonella

Websites

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