Epernicus: Parth Patwari, M.D., Sc.D.

Parth Patwari, M.D., Sc.D.

Position:
Instructor

Medicine

Brigham and Women's Hospital (Boston, MA)
Degrees:

Sc.D., Electrical Engineering, Massachusetts Institute of Technology (Cambridge, MA)

M.D., Medicine, Northwestern University Feinberg School of Medicine (Chicago, IL)

B.Sc., Biomedical Engineering, Northwestern University (Evanston, IL)
Past Advisors:

Richard T Lee (as Post Doctoral Fellow)

Alan J Grodzinsky (as Graduate Student - Ph.D.)
Research:

Communities:

Parth Patwari's Genealogy

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Parth Patwari's Publications (22)

The arrestin domain-containing 3 protein regulates body mass and energy expenditure.
Patwari P, Emilsson V, Schadt EE, Chutkow WA, Lee S, Marsili A, Zhang Y, Dobrin R, Cohen DE, Larsen PR, Zavacki AM, Fong LG, Young SG, Lee RT

Cell metabolism. 2011 Nov 2;14(5):671-83
Intraarticular injection of heparin-binding insulin-like growth factor 1 sustains delivery of insulin-like growth factor 1 to cartilage through binding to chondroitin sulfate.
Miller RE, Grodzinsky AJ, Cummings K, Plaas AH, Cole AA, Lee RT, Patwari P

Arthritis and rheumatism. 2010 Dec;62(12):3686-94
Deletion of the alpha-arrestin protein Txnip in mice promotes adiposity and adipogenesis while preserving insulin sensitivity.
Chutkow WA, Birkenfeld AL, Brown JD, Lee HY, Frederick DW, Yoshioka J, Patwari P, Kursawe R, Cushman SW, Plutzky J, Shulman GI, Samuel VT, Lee RT

Diabetes. 2010 Jun;59(6):1424-34
Thioredoxin-independent regulation of metabolism by the alpha-arrestin proteins.
Patwari P, Chutkow WA, Cummings K, Verstraeten VL, Lammerding J, Schreiter ER, Lee RT

The Journal of biological chemistry. 2009 Sep 11;284(37):24996-5003
Potent inhibition of cartilage biosynthesis by coincubation with joint capsule through an IL-1-independent pathway.
Patwari P, Lin SN, Kurz B, Cole AA, Kumar S, Grodzinsky AJ

Scandinavian journal of medicine & science in sports. 2009 Aug;19(4):528-35
Mechanical control of tissue morphogenesis.
Patwari P, Lee RT

Circulation research. 2008 Aug 1;103(3):234-43
Engineering insulin-like growth factor-1 for local delivery.
Tokunou T, Miller R, Patwari P, Davis ME, Segers VF, Grodzinsky AJ, Lee RT

The FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2008 Jun;22(6):1886-93
Thioredoxin-interacting protein (Txnip) is a critical regulator of hepatic glucose production.
Chutkow WA, Patwari P, Yoshioka J, Lee RT

The Journal of biological chemistry. 2008 Jan 25;283(4):2397-406
Thioredoxins, mitochondria, and hypertension.
Patwari P, Lee RT

The American journal of pathology. 2007 Mar;170(3):805-8
Analysis of the relationship between peak stress and proteoglycan loss following injurious compression of human post-mortem knee and ankle cartilage.
Patwari P, Cheng DM, Cole AA, Kuettner KE, Grodzinsky AJ

Biomechanics and modeling in mechanobiology. 2007 Jan;6(1-2):83-9
The interaction of thioredoxin with Txnip. Evidence for formation of a mixed disulfide by disulfide exchange.
Patwari P, Higgins LJ, Chutkow WA, Yoshioka J, Lee RT

The Journal of biological chemistry. 2006 Aug 4;281(31):21884-91
Analysis of ADAMTS4 and MT4-MMP indicates that both are involved in aggrecanolysis in interleukin-1-treated bovine cartilage.
Patwari P, Gao G, Lee JH, Grodzinsky AJ, Sandy JD

Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society. 2005 Apr;13(4):269-77
Mechanisms and kinetics of glycosaminoglycan release following in vitro cartilage injury.
DiMicco MA, Patwari P, Siparsky PN, Kumar S, Pratta MA, Lark MW, Kim YJ, Grodzinsky AJ

Arthritis and rheumatism. 2004 Mar;50(3):840-8
Ultrastructural quantification of cell death after injurious compression of bovine calf articular cartilage.
Patwari P, Gaschen V, James IE, Berger E, Blake SM, Lark MW, Grodzinsky AJ, Hunziker EB

Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society. 2004 Mar;12(3):245-52
Influence of tissue maturation and antioxidants on the apoptotic response of articular cartilage after injurious compression.
Kurz B, Lemke A, Kehn M, Domm C, Patwari P, Frank EH, Grodzinsky AJ, Schünke M

Arthritis and rheumatism. 2004 Jan;50(1):123-30
Individual cartilage aggrecan macromolecules and their constituent glycosaminoglycans visualized via atomic force microscopy.
Ng L, Grodzinsky AJ, Patwari P, Sandy J, Plaas A, Ortiz C

Journal of structural biology. 2003 Sep;143(3):242-57
Proteoglycan degradation after injurious compression of bovine and human articular cartilage in vitro: interaction with exogenous cytokines.
Patwari P, Cook MN, DiMicco MA, Blake SM, James IE, Kumar S, Cole AA, Lark MW, Grodzinsky AJ

Arthritis and rheumatism. 2003 May;48(5):1292-301
Molecular basis of osteoarthritis: biomechanical aspects.
Kerin A, Patwari P, Kuettner K, Cole A, Grodzinsky A

Cellular and molecular life sciences : CMLS. 2002 Jan;59(1):27-35
Biosynthetic response and mechanical properties of articular cartilage after injurious compression.
Kurz B, Jin M, Patwari P, Cheng DM, Lark MW, Grodzinsky AJ

Journal of orthopaedic research : official publication of the Orthopaedic Research Society. 2001 Nov;19(6):1140-6
In vitro models for investigation of the effects of acute mechanical injury on cartilage.
Patwari P, Fay J, Cook MN, Badger AM, Kerin AJ, Lark MW, Grodzinsky AJ

Clinical orthopaedics and related research. 2001 Oct;(391 Suppl):S61-71
Assessment of coronary plaque with optical coherence tomography and high-frequency ultrasound.
Patwari P, Weissman NJ, Boppart SA, Jesser C, Stamper D, Fujimoto JG, Brezinski ME

The American journal of cardiology. 2000 Mar 1;85(5):641-4
Mannosamine inhibits aggrecanase-mediated changes in the physical properties and biochemical composition of articular cartilage.
Patwari P, Kurz B, Sandy JD, Grodzinsky AJ

Archives of biochemistry and biophysics. 2000 Feb 1;374(1):79-85

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Parth Patwari, M.D., Sc.D.

Instructor

Parth Patwari's Genealogy

Parth Patwari's Publications (22)