Omar Duramad

Omar Duramad, Ph.D.

  • Position:
    Immunologist

    Independent

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  • Degrees:
     
    Ph.D., Immunology & Cancer Biology, University of Texas M. D. Anderson Cancer Center (Houston, TX)
     
    B.S., Cell Biology & Biochemistry, University of California, San Diego (San Diego, CA)
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  • Past Advisors:
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  • Research:
    My lab is currently investigating Foxp3+ Regulatory T cells in Autoimmunity, Transplantation, and Cancer.

    Regulatory T cells (Tregs) expressing the forkhead transcription factor Foxp3 play a central role in the dominant control of immunological tolerance. AUTOIMMUNITY & TRANSPLANTATION RESEARCH: The discovery, development and commercialization of immune regulatory therapeutics to treat life-threatening and debilitating conditions, including allergies, autoimmune diseases and transplantation via the pharmacological induction of antigen-specific regulatory T cells could potentially result in long-lasting immune tolerance. My lab currently investigates compounds that stimulate Foxp3+ Regulatory T cells to expand in different disease indications such as transplantation and autoimmune /inflammatory diseases. CANCER RESEARCH: Compelling evidence obtained from both animal and clinical studies have now linked the expansion and accumulation of Foxp3+ regulatory T cells associated with tumor lesions to the failure of immune-mediated tumor rejection. My lab currently investigates potential drug targets that may inhibit Foxp3+ Regulatory T cell function and reduce their expansion in cancer. Understanding the mode of action of these compounds will contribute to the development of novel therapeutics relevant for the induction of tolerance in autoimmunity / transplantation and enhancing immune-mediated tumor rejection mechanisms.

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Life Sciences
Health Sciences
Communities:

Omar Duramad's Genealogy

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Omar Duramad's Publications (12)



Omar Duramad's Posters and Presentations (13)

  • Donor-Specific Tolerance Induction by a Liposomal Formulation of KRN7000 (RGI-2001) Alone and in Combination with Low-Dose Sirolimus (poster)

    Omar Duramad, Amy Laysang, Jun Li, Yasuyuki Ishii, and Reiko Namikawa

    2009 American Transplant Congress (Boston); 06/2009
  • A Liposomal Formulation of KRN7000 (RGI-2001) Potently Reduces GvHD Lethality through the Expansion of CD4+Foxp3+ Regulatory T cells in Murine Models (poster)

    Omar Duramad*1, Amy Laysang*1, Jun Li*1, Yasuyuki Ishii*2, Reiko Namikawa 1

    50th American Society of Hematology Annual Meeting and Exposition; 12/2008
  • Donor-Specific Tolerance Induction through Expansion of DCregs and Tregs by a Liposomal Formulation of KRN7000 (RGI-2001) (poster)

    Omar Duramad*1, Amy Laysang*1, Jun Li*1, Yasuyuki Ishii*2, Reiko Namikawa 1

    50th American Society of Hematology Annual Meeting and Exposition; 12/2008
  • A Liposomal Formulation of KRN7000 (RGI-2001) Potently Reduces GvHD Lethality through the Expansion of CD4+Foxp3+ Regulatory T cells in Murine Models. (poster)

    Omar Duramad

    The Eleventh Biennial National Symposium on Hematopoietic Cell transplantation; 11/2008
  • Inhibition of antigen-specific antibody responses by a liposome containing -galctocyceramide with antigenic peptides through the generation of tolergenic APCs and adaptive Tregs (poster)

    Yukiko Takamoto, Risa Nozawa, Annabelle Teng, Haruka Katagiri, Omar Duramad, & Yasuyuki Ishii

    Keystone Symposia – NK and NKT Cell Biology; 10/2007
  • Dynamics of Foxp3+Regulatory T cells during Tumor Progression (presentation)

    Omar Duramad

    RIKEN Summer Program for Allergy and Immunology; 07/2007
  • Origin and Dynamics of Tumor-Associated Foxp3+ Regulatory T cells (poster)

    Omar Duramad, Olivia A. Perng, M. Anna Zal, Yong-Jun Liu, Tomasz Zal, & F. Xiao-Feng Qin

    American Association of Immunologists – 94th Meeting; 05/2007
  • Origin and Dynamics of Tumor-Associated Foxp3+ Regulatory T cells (presentation)

    Omar Duramad

    Keystone Symposia – Regulatory T cells ; 02/2007
  • Visualization of spatiotemporal dynamics of endogenous Foxp3+ regulatory T cells in solid tumors (poster)

    Tomasz Zal, Omar Duramad, Olivia A. Perng, M. Anna Zal, & F. Xiao-Feng Qin

    American Society for Cell Biology; 10/2006
  • Oligonucleotide-based Inhibitors of TLR -7, -8 and -9 and their Potential for the Treatment of Systemic Lupus Erythematosus (SLE) (poster)

    Franck J. Barrat, Thea Meeker, Jean H. Chan, Omar Duramad, Josh Gregorio, Bonnie Chang and Robert L. Coffman

    Midwinter Conference of Immunologists; 01/2005
  • The role of TNF-a in plasmacytoid dendritic cell development (poster)

    Omar Duramad, Yui-Hsi Wang, Olivia A. Perng, Yong-Jun Liu, and F. Xiao-Feng Qin

    MD Anderson Cancer Center Symposium on Cancer Immunology; 10/2004
  • IL-10 and Immunoregulatory DNA Oligonucleotides (IRS) Modulate Innate Immune Responses to CpG-Containing DNA Sequences (ISS) (poster)

    Franck J. Barrat, Thea Meeker, Josh Gregorio, Jean H. Chan, Satoshi Uematsu, Shizuo Akira, Bonnie Chang, Omar Duramad and Robert L. Coffman

    12th International Congress of Immunology; 07/2004
  • IL-10 and Immunoregulatory DNA Oligonucleotides (IRS) as Ways to Modulate Innate Immune Responses to TLR ligands (poster)

    Omar Duramad, Karen L. Fearon, Bonnie Chang, Jean H. Chan, Josh Gregorio, Robert L. Coffman, and Franck J. Barrat

    Toll 2004; 03/2004

One Figure

One Figure for Omar Duramad

Foxp3+ Regulatory T cells (Green) around Tumors (Red)


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