Epernicus: Feng Zhang, Ph.D.

Feng Zhang, Ph.D.

Position:
Associate Professor

School of Life Sciences

State Key Laboratory of Genetic Engineering and MOE Key Laboratory of Contemporary Anthropology

Fudan University (Shanghai, China)
Degrees:

Ph.D., Genetics, Fudan University (Shanghai, China)
Past Advisors:

James R. Lupski (as Post Doctoral Fellow)

Li Jin (as Graduate Student - Ph.D.)
Research:
Human genomic rearrangements; Copy number variations (CNVs), and their roles in human diseases and genome evolution.

Communities:

Feng Zhang's Genealogy

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Feng Zhang's Publications (30)

Structural variation of the human genome: mechanisms, assays, and role in male infertility.
Carvalho CM, Zhang F, Lupski JR

Systems biology in reproductive medicine. 2011 Feb.;57(1-2):3-16
Potocki-Lupski Syndrome: A Microduplication Syndrome Associated with Oropharyngeal Dysphagia and Failure to Thrive.
Soler-Alfonso C, Motil KJ, Turk CL, Robbins-Furman P, Friedman EM, Zhang F, Lupski JR, Fraley JK, Potocki L

The Journal of pediatrics. 2010 Dec 16
GJB1/Connexin 32 whole gene deletions in patients with X-linked Charcot-Marie-Tooth disease.
Gonzaga-Jauregui C, Zhang F, Towne CF, Batish SD, Lupski JR

Neurogenetics. 2010 Oct;11(4):465-70
Identification of copy number variation hotspots in human populations.
Fu W, Zhang F, Wang Y, Gu X, Jin L

American journal of human genetics. 2010 Oct 8;87(4):494-504
Deletion and duplication of 15q24: molecular mechanisms and potential modification by additional copy number variants.
El-Hattab AW, Zhang F, Maxim R, Christensen KM, Ward JC, Hines-Dowell S, Scaglia F, Lupski JR, Cheung SW

Genetics in medicine : official journal of the American College of Medical Genetics. 2010 Sep;12(9):573-86
Mechanisms for nonrecurrent genomic rearrangements associated with CMT1A or HNPP: rare CNVs as a cause for missing heritability.
Zhang F, Seeman P, Liu P, Weterman MA, Gonzaga-Jauregui C, Towne CF, Batish SD, De Vriendt E, De Jonghe P, Rautenstrauss B, Krause KH, Khajavi M, Posadka J, Vandenberghe A, Palau F, Van Maldergem L, Baas F, Timmerman V, Lupski JR

American journal of human genetics. 2010 Jun 11;86(6):892-903
Whole-genome sequencing in a patient with Charcot-Marie-Tooth neuropathy.
Lupski JR, Reid JG, Gonzaga-Jauregui C, Rio Deiros D, Chen DC, Nazareth L, Bainbridge M, Dinh H, Jing C, Wheeler DA, McGuire AL, Zhang F, Stankiewicz P, Halperin JJ, Yang C, Gehman C, Guo D, Irikat RK, Tom W, Fantin NJ, Muzny DM, Gibbs RA

The New England journal of medicine. 2010 Apr 1;362(13):1181-91
Identification of uncommon recurrent Potocki-Lupski syndrome-associated duplications and the distribution of rearrangement types and mechanisms in PTLS.
Zhang F, Potocki L, Sampson JB, Liu P, Sanchez-Valle A, Robbins-Furman P, Navarro AD, Wheeler PG, Spence JE, Brasington CK, Withers MA, Lupski JR

American journal of human genetics. 2010 Mar 12;86(3):462-70
Evolution in health and medicine Sackler colloquium: Genomic disorders: a window into human gene and genome evolution.
Carvalho CM, Zhang F, Lupski JR

Proceedings of the National Academy of Sciences of the United States of America. 2010 Jan 26;107 Suppl 1:1765-71
Autism and other neuropsychiatric symptoms are prevalent in individuals with MeCP2 duplication syndrome.
Ramocki MB, Peters SU, Tavyev YJ, Zhang F, Carvalho CM, Schaaf CP, Richman R, Fang P, Glaze DG, Lupski JR, Zoghbi HY

Annals of neurology. 2009 Dec;66(6):771-82
Microdeletions including YWHAE in the Miller-Dieker syndrome region on chromosome 17p13.3 result in facial dysmorphisms, growth restriction, and cognitive impairment.
Nagamani SC, Zhang F, Shchelochkov OA, Bi W, Ou Z, Scaglia F, Probst FJ, Shinawi M, Eng C, Hunter JV, Sparagana S, Lagoe E, Fong CT, Pearson M, Doco-Fenzy M, Landais E, Mozelle M, Chinault AC, Patel A, Bacino CA, Sahoo T, Kang SH, Cheung SW, Lupski JR, Stankiewicz P

Journal of medical genetics. 2009 Dec;46(12):825-33
Genomic duplication resulting in increased copy number of genes encoding the sister chromatid cohesion complex conveys clinical consequences distinct from Cornelia de Lange.
Yan J, Zhang F, Brundage E, Scheuerle A, Lanpher B, Erickson RP, Powis Z, Robinson HB, Trapane PL, Stachiw-Hietpas D, Keppler-Noreuil KM, Lalani SR, Sahoo T, Chinault AC, Patel A, Cheung SW, Lupski JR

Journal of medical genetics. 2009 Sep;46(9):626-34
Complex human chromosomal and genomic rearrangements.
Zhang F, Carvalho CM, Lupski JR

Trends in genetics : TIG. 2009 Jul;25(7):298-307
The DNA replication FoSTeS/MMBIR mechanism can generate genomic, genic and exonic complex rearrangements in humans.
Zhang F, Khajavi M, Connolly AM, Towne CF, Batish SD, Lupski JR

Nature genetics. 2009 Jul;41(7):849-53
Complex rearrangements in patients with duplications of MECP2 can occur by fork stalling and template switching.
Carvalho CM, Zhang F, Liu P, Patel A, Sahoo T, Bacino CA, Shaw C, Peacock S, Pursley A, Tavyev YJ, Ramocki MB, Nawara M, Obersztyn E, Vianna-Morgante AM, Stankiewicz P, Zoghbi HY, Cheung SW, Lupski JR

Human molecular genetics. 2009 Jun 15;18(12):2188-203
Association of polymorphisms in four bilirubin metabolism genes with serum bilirubin in three Asian populations.
Lin R, Wang X, Wang Y, Zhang F, Wang Y, Fu W, Yu T, Li S, Xiong M, Huang W, Jin L

Human mutation. 2009 Apr;30(4):609-15
The b2/b3 subdeletion shows higher risk of spermatogenic failure and higher frequency of complete AZFc deletion than the gr/gr subdeletion in a Chinese population.
Lu C, Zhang J, Li Y, Xia Y, Zhang F, Wu B, Wu W, Ji G, Gu A, Wang S, Jin L, Wang X

Human molecular genetics. 2009 Mar 15;18(6):1122-30
Increased LIS1 expression affects human and mouse brain development.
Bi W, Sapir T, Shchelochkov OA, Zhang F, Withers MA, Hunter JV, Levy T, Shinder V, Peiffer DA, Gunderson KL, Nezarati MM, Shotts VA, Amato SS, Savage SK, Harris DJ, Day-Salvatore DL, Horner M, Lu XY, Sahoo T, Yanagawa Y, Beaudet AL, Cheung SW, Martinez S, Lupski JR, Reiner O

Nature genetics. 2009 Feb;41(2):168-77
Copy number variation in human health, disease, and evolution.
Zhang F, Gu W, Hurles ME, Lupski JR

Annual review of genomics and human genetics. 2009;10:451-81
A spatial analysis of genetic structure of human populations in China reveals distinct difference between maternal and paternal lineages.
Xue F, Wang Y, Xu S, Zhang F, Wen B, Wu X, Lu M, Deka R, Qian J, Jin L

European journal of human genetics : EJHG. 2008 Jun;16(6):705-17
The clinical spectrum associated with a chromosome 17 short arm proximal duplication (dup 17p11.2) in three patients.
Doco-Fenzy M, Holder-Espinasse M, Bieth E, Magdelaine C, Vincent MC, Khoury M, Andrieux J, Zhang F, Lupski JR, Klink R, Schneider A, Goze-Martineau O, Cuisset JM, Vallee L, Manouvrier-Hanu S, Gaillard D, de Martinville B

American journal of medical genetics. Part A. 2008 Apr 1;146(7):917-24
Mechanisms for human genomic rearrangements.
Gu W, Zhang F, Lupski JR

PathoGenetics. 2008;1(1):4
Y chromosome evidence of earliest modern human settlement in East Asia and multiple origins of Tibetan and Japanese populations.
Shi H, Zhong H, Peng Y, Dong YL, Qi XB, Zhang F, Liu LF, Tan SJ, Ma RZ, Xiao CJ, Wells RS, Jin L, Su B

BMC biology. 2008;6:45
Rapid evolution, genetic variations, and functional association of the human spermatogenesis-related gene NYD-SP12.
Zhang Q, Zhang F, Chen XH, Wang YQ, Wang WQ, Lin AA, Cavalli-Sforza LL, Jin L, Huo R, Sha JH, Li Z, Su B

Journal of molecular evolution. 2007 Aug;65(2):154-61
Partial deletions are associated with an increased risk of complete deletion in AZFc: a new insight into the role of partial AZFc deletions in male infertility.
Zhang F, Lu C, Li Z, Xie P, Xia Y, Zhu X, Wu B, Cai X, Wang X, Qian J, Wang X, Jin L

Journal of medical genetics. 2007 Jul;44(7):437-44

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One Figure

Complex 17p rearrangement

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