Donald S Berkholz

Donald S Berkholz, Ph.D.

  • Positions:
    IT Industry Analyst

    RedMonk

    Research Collaborator

    Physiology & Biomedical Engineering

    Pediatric & Adolescent Medicine

    Mayo Clinic (Rochester, MN)

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  • Degrees:
     
    Ph.D., Biochemistry & Biophysics, Oregon State University (Corvallis, OR)
     
    B.S., Biochemistry & Molecular Biology, University of Richmond (Richmond, VA)
     
    B.A., Chemistry, University of Richmond (Richmond, VA)
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  • Past Advisors:
     
    James R. Thompson (as Post Doctoral Fellow)
     
    Grazia Isaya (as Post Doctoral Fellow)
     
    P. Andrew Karplus (as Graduate Student - Ph.D.)
     
    J. Ellis Bell (as Undergraduate Student)
     
    Leonard J Banaszak (as Visiting Student)
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  • Research:
    My thesis work focused on understanding protein structure at atomic resolution and leveraging that understanding to improve modeling and crystallographic refinement -- an extension of my broader interest in structure-function relationships.
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  • Other Experience:

    2003-present Gentoo Linux developer

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  • Honors:

    2010 Poster reviewer in structural enzymology — American Crystallographic Association

    2010 Travel grant — American Crystallographic Association

    2010 NIGMS Workshop for Postdocs Transitioning to Independent Positions — NIH/NIGMS

    2010-2012 Postdoctoral fellowship — American Heart Association

    2009 Best Student Talk award — West Coast Protein Crystallography Workshop

    2008 College of Science Student Travel Award — OSU

    2008 Finn Wold award — Protein Society

    2002 John C. Johnson Award in molecular biology (2nd prize poster) — Tri-Beta biological honor society national convention

    2002 1st prize undergraduate poster — American Society for Biochemistry and Molecular Biology

    2002 Presidential Student-Faculty Collaboration Grant — Gustavus

    2000 Partners in Scholarship ($12,500/year) — Gustavus

    2000 Presidential Scholarship ($10,000/year) — Gustavus

    2000 National Merit Scholar

    1999 Eagle Scout

Life Sciences
Communities:

Donald Berkholz's Genealogy

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Donald Berkholz's Publications (7)



Donald Berkholz's Posters and Presentations (5)

  • Applying structure-based drug design to the moonlighting enzyme dihydrolipoamide dehydrogenase to target detrimental oxidative stress (presentation)

    Donald Berkholz, Rachael Vaubel, Christina Andrist, Grazia Isaya, James R. Thompson

    American Crystallographic Association; 07/2010
  • Beyond Linus Pauling: Conformation dependence of ideal geometry in proteins (presentation)

    Donald Berkholz, Maxim Chapovalov, Roland Dunbrack Jr, P. Andrew Karplus

    West Coast Protein Crystallography Workshop; 04/2009
  • Glutathione reductase catalysis at atomic resolution (poster)

    Donald S Berkholz

    West Coast Protein Crystallography Workshop; 04/2007
  • Conformations of 5-hydroxytryptamine (serotonin) in solution (poster)

    Donald S. Berkholz, Jonathan M. Smith

    MERCURY Conference in Computational Chemistry; 07/2002
  • Probing the active site of 3-phosphoglycerate dehydrogenase: the role of acidbase catalysis and the local charge environment of the transition state in V-type regulation by serine (poster)

    Donald S. Berkholz, J. Ellis Bell

    American Society for Biochemistry and Molecular Biology; 04/2002

One Figure

One Figure for Donald S Berkholz

Protein backbones have covalent geometry that varies as a function of their conformation (i.e., bond angles and lengths vary as a function of Φ and Ψ). This figure shows how those variations have a structural basis and make some conformations accessible.


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