Dominique Helmlinger

Dominique Helmlinger, Ph.D.

  • Position:
    Post Doctoral Fellow

    Genetics

    Harvard Medical School (Boston, MA)

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  • Advisor:

    Fred Winston

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  • Degrees:
     
    Ph.D., Molecular & Cellular Biology, University Louis Pasteur - Institute of Genetics and Molecular and Cellular Biology
     
    B.Sc., Statistics, Louis Pasteur University (Strasbourg, France)
     
    M.Sc., Molecular & Cellular Biology, Louis Pasteur University (Strasbourg, France)
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  • Past Advisors:
     
    Laszlo Tora (as Visiting Student)
     
    Didier Devys (as Graduate Student - Ph.D.)
     
    Jean-Louis Mandel (as Graduate Student - Masters)
     
    Marc Bigaud (as Undergraduate Student)
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  • Research:
    Analysis of transcriptional coactivator complexes in the fission yeast Schizosaccharomyces pombe

    My interest is how transcription is regulated in response to environmental changes in the fission yeast Schizosaccharomyces pombe. My focus is on a multiprotein complex, named SAGA, originally discovered in the budding yeast Saccharomyces cerevisiae, which controls transcription initiation by RNA polymerase II. S. pombe is highly divergent from S. cerevisiae and recent work have shown that chromatin organization and transcriptional regulation in S. pombe are remarkably different from that in S. cerevisiae and directly relevant to higher eukaryotes. I have purified and started the functional characterization of the SAGA complex in S. pombe and discovered roles for S. pombe SAGA in key cellular processes, such as the switch from vegetative growth to sexual differentiation or cytokinesis.

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  • Honors:

    2006-2009 Human Frontier Science Program Organization Long-Term Post-Doctoral Fellowship

    2005 Jean Kepler Thesis Award

    2004 Medical Research Foundation Graduate Student Fellowship

    2000-2003 French Ministry for Research and Technology Graduate Student Fellowship

    1999 French Ministry for Research and Technology Master Student Fellowship

Life Sciences
Communities:

Dominique Helmlinger's Genealogy

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Dominique Helmlinger's Publications (13)



Dominique Helmlinger's Posters and Presentations (5)

  • The S. pombe SAGA complex control the switch from proliferation to sexual differentiation through the opposing roles of its subunits Gcn5 and Spt8 (presentation)

    Helmlinger D., Marguerat S., Villén J., Gygi SP., Bähler J. and Winston F.

    North American Fission Yeast Meeting, Los Angeles, CA; 06/2008
  • The SAGA component Gcn5 negatively regulates sexual differentiation in fission yeast (presentation)

    Helmlinger D., Marguerat S., Villén J., Gygi SP., Bähler J. and Winston F.

    Fourth International Fission Yeast Meeting, Copenhagen, Denmark; 06/2007
  • Chromatin remodeling and transcriptional alterations in polyglutamine expansion diseases (poster)

    Helmlinger D., Hardy S., Abou-Sleymane G., Tora L. and Devys D.

    6th EMBL Transcription Meeting, EMBL-Heidelberg, Germany; 08/2004
  • Polyglutamine expansions induce irreversible chromatin remodeling leading to transcriptional dysregulation in SCA7 and HD transgenic mice (presentation)

    Helmlinger D., Abou-Sleymane G., Cammas F., Gansmüller A., Picaud S., Mandel J.L. and Devys D.

    Chromatin Meeting, Luxembourg; 01/2004
  • Progressive retinal degeneration in R6 mice (presentation)

    Helmlinger D., Yvert G., Mandel J.L. and Devys D.

    Hereditary Disease Foundation Biannual Meeting, Cambridge, MA; 08/2002

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One Figure for Dominique Helmlinger

This is what I work on...


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