Epernicus: Goldis Malek, Ph.D.

Goldis Malek, Ph.D.

Position:
Assistant Professor

Ophthalmology

Pathology

Duke University School of Medicine (Durham, NC)
Degrees:

Ph.D., Vision science and physiological optics, University of Alabama at Birmingham (Birmingham, AL)

B.S., Biology, University of South Florida (Tampa, FL)

B.A., Psychology, University of South Florida (Tampa, FL)
Past Advisors:

Catherine Bowes Rickman, (as Post Doctoral Fellow)

Christine A Curcio (as Graduate Student - Ph.D.)

Samuel Edwards (as Undergraduate Student)
Research:
I am interested in identifying the role of nuclear receptors in the progression and initiation of retinal diseases including age-related macular degeneration and diabetic retinopathy.

Communities:

Goldis Malek's Genealogy

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Goldis Malek's Publications (18)

Research resource: nuclear receptor atlas of human retinal pigment epithelial cells: potential relevance to age-related macular degeneration.
Dwyer MA, Kazmin D, Hu P, McDonnell DP, Malek G

Molecular endocrinology (Baltimore, Md.). 2011 Feb;25(2):360-72
The pivotal role of the complement system in aging and age-related macular degeneration: hypothesis re-visited.
Anderson DH, Radeke MJ, Gallo NB, Chapin EA, Johnson PT, Curletti CR, Hancox LS, Hu J, Ebright JN, Malek G, Hauser MA, Rickman CB, Bok D, Hageman GS, Johnson LV

Progress in retinal and eye research. 2010 Mar;29(2):95-112
Reticular pseudodrusen are subretinal drusenoid deposits.
Zweifel SA, Spaide RF, Curcio CA, Malek G, Imamura Y

Ophthalmology. 2010 Feb;117(2):303-12.e1
PPAR nuclear receptors and altered RPE lipid metabolism in age-related macular degeneration.
Malek G, Hu P, Wielgus A, Dwyer M, Cousins S

Advances in experimental medicine and biology. 2010;664:429-36
Sub-retinal drusenoid deposits in human retina: organization and composition.
Rudolf M, Malek G, Messinger JD, Clark ME, Wang L, Curcio CA

Experimental eye research. 2008 Nov;87(5):402-8
Recurrent choroidal neovascularization after macular translocation surgery with 360-degree peripheral retinectomy.
Baer CA, Rickman CB, Srivastava S, Malek G, Stinnett S, Toth CA

Retina (Philadelphia, Pa.). 2008 Oct;28(9):1221-7
ERG responses and microarray analysis of gene expression in a multifactorial murine model of age-related retinal degeneration.
Malek G, Jamison JA, Mace B, Sullivan P, Rickman CB

Advances in experimental medicine and biology. 2008;613:165-70
Oxidative stress-induced expression and modulation of Phosphatase of Regenerating Liver-1 (PRL-1) in mammalian retina.
Yu L, Kelly U, Ebright JN, Malek G, Saloupis P, Rickman DW, McKay BS, Arshavsky VY, Bowes Rickman C

Biochimica et biophysica acta. 2007 Sep;1773(9):1473-82
Molecular genetics of AMD and current animal models.
Edwards AO, Malek G

Angiogenesis. 2007;10(2):119-32
Is our current clinical classification of AMD up to the job?
Malek G, Cousins SW

The British journal of ophthalmology. 2006 Sep;90(9):1080-1
Initial observations of key features of age-related macular degeneration in APOE targeted replacement mice.
Malek G, Mace B, Saloupis P, Schmechel D, Rickman D, Sullivan P, Rickman CB

Advances in experimental medicine and biology. 2006;572:109-17
Esterified and unesterified cholesterol in drusen and basal deposits of eyes with age-related maculopathy.
Curcio CA, Presley JB, Malek G, Medeiros NE, Avery DV, Kruth HS

Experimental eye research. 2005 Dec;81(6):731-41
Apolipoprotein E allele-dependent pathogenesis: a model for age-related retinal degeneration.
Malek G, Johnson LV, Mace BE, Saloupis P, Schmechel DE, Rickman DW, Toth CA, Sullivan PM, Bowes Rickman C

Proceedings of the National Academy of Sciences of the United States of America. 2005 Aug 16;102(33):11900-5
Lipoprotein-like particles and cholesteryl esters in human Bruch's membrane: initial characterization.
Li CM, Chung BH, Presley JB, Malek G, Zhang X, Dashti N, Li L, Chen J, Bradley K, Kruth HS, Curcio CA

Investigative ophthalmology & visual science. 2005 Jul;46(7):2576-86
Insulin-like growth factor-1 contributes to neovascularization in age-related macular degeneration.
Rosenthal R, Wohlleben H, Malek G, Schlichting L, Thieme H, Bowes Rickman C, Strauss O

Biochemical and biophysical research communications. 2004 Oct 29;323(4):1203-8
Apolipoprotein B in cholesterol-containing drusen and basal deposits of human eyes with age-related maculopathy.
Malek G, Li CM, Guidry C, Medeiros NE, Curcio CA

The American journal of pathology. 2003 Feb;162(2):413-25
Dominant late-onset retinal degeneration with regional variation of sub-retinal pigment epithelium deposits, retinal function, and photoreceptor degeneration.
Milam AH, Curcio CA, Cideciyan AV, Saxena S, John SK, Kruth HS, Malek G, Heckenlively JR, Weleber RG, Jacobson SG

Ophthalmology. 2000 Dec;107(12):2256-66
Peripapillary chorioretinal atrophy: Bruch's membrane changes and photoreceptor loss.
Curcio CA, Saunders PL, Younger PW, Malek G

Ophthalmology. 2000 Feb;107(2):334-43

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Goldis Malek, Ph.D.

Assistant Professor

I am interested in identifying the role of nuclear receptors in the progression and initiation of retinal diseases including age-related macular degeneration and diabetic retinopathy.

Goldis Malek's Genealogy

Goldis Malek's Publications (18)