Epernicus: Paul D. Kaufman, Ph.D.

Paul D. Kaufman, Ph.D.

Position:
Associate Professor

Program in Gene Function and Expression

Program in Molecular Medicine

University of Massachusetts Medical School (Worcester, MA)
Degrees:

Ph.D., Biology, Massachusetts Institute of Technology (Cambridge, MA)
Past Advisors:

Bruce Stillman (as Post Doctoral Fellow)

Donald C. Rio (as Graduate Student - Ph.D.)
Research:
Deposition and modification of chromosome proteins and their roles in genome stability.

Communities:

Paul Kaufman's Genealogy

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Paul Kaufman's Publications (34)

Cell cycle- and chaperone-mediated regulation of H3K56ac incorporation in yeast.
Kaplan T, Liu CL, Erkmann JA, Holik J, Grunstein M, Kaufman PD, Friedman N, Rando OJ

PLoS genetics. 2008 Nov;4(11):e1000270
Molecular functions of the histone acetyltransferase chaperone complex Rtt109-Vps75.
Berndsen CE, Tsubota T, Lindner SE, Lee S, Holton JM, Kaufman PD, Keck JL, Denu JM

Nature structural & molecular biology. 2008 Aug 10
Histone H3-K56 acetylation is catalyzed by histone chaperone-dependent complexes.
Tsubota T, Berndsen CE, Erkmann JA, Smith CL, Yang L, Freitas MA, Denu JM, Kaufman PD

Molecular cell. 2007 Mar 9;25(5):703-12
Histone chaperone Asf1 is required for histone H3 lysine 56 acetylation, a modification associated with S phase in mitosis and meiosis.
Recht J, Tsubota T, Tanny JC, Diaz RL, Berger JM, Zhang X, Garcia BA, Shabanowitz J, Burlingame AL, Hunt DF, Kaufman PD, Allis CD

Proceedings of the National Academy of Sciences of the United States of America. 2006 May 2;103(18):6988-93
Structure of the yeast histone H3-ASF1 interaction: implications for chaperone mechanism, species-specific interactions, and epigenetics.
Antczak AJ, Tsubota T, Kaufman PD, Berger JM

BMC structural biology. 2006;6:26
Regulation of histone deposition proteins Asf1/Hir1 by multiple DNA damage checkpoint kinases in Saccharomyces cerevisiae.
Sharp JA, Rizki G, Kaufman PD

Genetics. 2005 Nov;171(3):885-99
Replication-independent histone deposition by the HIR complex and Asf1.
Green EM, Antczak AJ, Bailey AO, Franco AA, Wu KJ, Yates JR, Kaufman PD

Current biology : CB. 2005 Nov 22;15(22):2044-9
Histone deposition protein Asf1 maintains DNA replisome integrity and interacts with replication factor C.
Franco AA, Lam WM, Burgers PM, Kaufman PD

Genes & development. 2005 Jun 1;19(11):1365-75
Formation of MacroH2A-containing senescence-associated heterochromatin foci and senescence driven by ASF1a and HIRA.
Zhang R, Poustovoitov MV, Ye X, Santos HA, Chen W, Daganzo SM, Erzberger JP, Serebriiskii IG, Canutescu AA, Dunbrack RL, Pehrson JR, Berger JM, Kaufman PD, Adams PD

Developmental cell. 2005 Jan;8(1):19-30
Histone deposition proteins: links between the DNA replication machinery and epigenetic gene silencing.
Franco AA, Kaufman PD

Cold Spring Harbor symposia on quantitative biology. 2004;69:201-8
Structure and function of the conserved core of histone deposition protein Asf1.
Daganzo SM, Erzberger JP, Lam WM, Skordalakes E, Zhang R, Franco AA, Brill SJ, Adams PD, Berger JM, Kaufman PD

Current biology : CB. 2003 Dec 16;13(24):2148-58
The budding yeast silencing protein Sir1 is a functional component of centromeric chromatin.
Sharp JA, Krawitz DC, Gardner KA, Fox CA, Kaufman PD

Genes & development. 2003 Oct 1;17(19):2356-61
Sas4 and Sas5 are required for the histone acetyltransferase activity of Sas2 in the SAS complex.
Sutton A, Shia WJ, Band D, Kaufman PD, Osada S, Workman JL, Sternglanz R

The Journal of biological chemistry. 2003 May 9;278(19):16887-92
Defective S phase chromatin assembly causes DNA damage, activation of the S phase checkpoint, and S phase arrest.
Ye X, Franco AA, Santos H, Nelson DM, Kaufman PD, Adams PD

Molecular cell. 2003 Feb;11(2):341-51
Chromatin proteins are determinants of centromere function.
Sharp JA, Kaufman PD

Current topics in microbiology and immunology. 2003;274:23-52
Defects in SPT16 or POB3 (yFACT) in Saccharomyces cerevisiae cause dependence on the Hir/Hpc pathway: polymerase passage may degrade chromatin structure.
Formosa T, Ruone S, Adams MD, Olsen AE, Eriksson P, Yu Y, Rhoades AR, Kaufman PD, Stillman DJ

Genetics. 2002 Dec;162(4):1557-71
Chromatin assembly factor I and Hir proteins contribute to building functional kinetochores in S. cerevisiae.
Sharp JA, Franco AA, Osley MA, Kaufman PD

Genes & development. 2002 Jan 1;16(1):85-100
Chromatin assembly factor I mutants defective for PCNA binding require Asf1/Hir proteins for silencing.
Krawitz DC, Kama T, Kaufman PD

Molecular and cellular biology. 2002 Jan;22(2):614-25
Yeast histone deposition protein Asf1p requires Hir proteins and PCNA for heterochromatic silencing.
Sharp JA, Fouts ET, Krawitz DC, Kaufman PD

Current biology : CB. 2001 Apr 3;11(7):463-73
Role of Saccharomyces cerevisiae chromatin assembly factor-I in repair of ultraviolet radiation damage in vivo.
Game JC, Kaufman PD

Genetics. 1999 Feb;151(2):485-97
Hir proteins are required for position-dependent gene silencing in Saccharomyces cerevisiae in the absence of chromatin assembly factor I.
Kaufman PD, Cohen JL, Osley MA

Molecular and cellular biology. 1998 Aug;18(8):4793-806
Nucleosomal DNA regulates the core-histone-binding subunit of the human Hat1 acetyltransferase.
Verreault A, Kaufman PD, Kobayashi R, Stillman B

Current biology : CB. 1998 Jan 15;8(2):96-108
Ultraviolet radiation sensitivity and reduction of telomeric silencing in Saccharomyces cerevisiae cells lacking chromatin assembly factor-I.
Kaufman PD, Kobayashi R, Stillman B

Genes & development. 1997 Feb 1;11(3):345-57
Nucleosome assembly by a complex of CAF-1 and acetylated histones H3/H4.
Verreault A, Kaufman PD, Kobayashi R, Stillman B

Cell. 1996 Oct 4;87(1):95-104
Chromatin assembly coupled to DNA repair: a new role for chromatin assembly factor I.
Gaillard PH, Martini EM, Kaufman PD, Stillman B, Moustacchi E, Almouzni G

Cell. 1996 Sep 20;86(6):887-96

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Paul D. Kaufman, Ph.D.

Associate Professor

Deposition and modification of chromosome proteins and their roles in genome stability.

Paul Kaufman's Genealogy

Paul Kaufman's Publications (34)