Epernicus: Philip D Jeffrey, D.Phil.

Philip D Jeffrey, D.Phil.

Position:
Crystallography Facility Manager

Molecular Biology

Princeton University (Princeton, NJ)
Degrees:

D.Phil., Structural Biology, University of Oxford (Oxford, UK)

B.A., Chemistry, University of Oxford (Oxford, UK)
Past Advisors:
Research:
Structural biology of proteins

3D structures of proteins by the method of X-ray crystallography. Current work mainly focuses on apoptosis and vesicle trafficking but previous work includes cell cycle regulation (CDKs, cyclins, p53), DNA repair (BRCA1, BRCA2), cell regulation (PP2A), intramembrane proteases (S2P, Rhomboid).
Other Experience:
1993-present Linux and OSX system administration

1993-present X-ray diffraction system maintenance and installation

1989-present Computer programming in C and Fortran (and a little Tcl, Java, OpenGL etc)

Communities:

Philip Jeffrey's Genealogy

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Philip Jeffrey's Publications (61)

Analysis of errors in the structure determination of MsbA.
Jeffrey PD

Acta crystallographica. Section D, Biological crystallography. 2009 Feb;65(Pt 2):193-9
Structural characterization of Tip20p and Dsl1p, subunits of the Dsl1p vesicle tethering complex.
Tripathi A, Ren Y, Jeffrey PD, Hughson FM

Nature structural & molecular biology. 2009 Feb;16(2):114-23
Structural basis of UV DNA-damage recognition by the DDB1-DDB2 complex.
Scrima A, Konícková R, Czyzewski BK, Kawasaki Y, Jeffrey PD, Groisman R, Nakatani Y, Iwai S, Pavletich NP, Thomä NH

Cell. 2008 Dec 26;135(7):1213-23
Structure of a protein phosphatase 2A holoenzyme: insights into B55-mediated Tau dephosphorylation.
Xu Y, Chen Y, Zhang P, Jeffrey PD, Shi Y

Molecular cell. 2008 Sep 26;31(6):873-85
Structural mechanism of demethylation and inactivation of protein phosphatase 2A.
Xing Y, Li Z, Chen Y, Stock JB, Jeffrey PD, Shi Y

Cell. 2008 Apr 4;133(1):154-63
Structure and metal exchange in the cadmium carbonic anhydrase of marine diatoms.
Xu Y, Feng L, Jeffrey PD, Shi Y, Morel FM

Nature. 2008 Mar 6;452(7183):56-61
Structure of a site-2 protease family intramembrane metalloprotease.
Feng L, Yan H, Wu Z, Yan N, Wang Z, Jeffrey PD, Shi Y

Science (New York, N.Y.). 2007 Dec 7;318(5856):1608-12
Structural basis for antiactivation in bacterial quorum sensing.
Chen G, Jeffrey PD, Fuqua C, Shi Y, Chen L

Proceedings of the National Academy of Sciences of the United States of America. 2007 Oct 16;104(42):16474-9
Structural and biochemical insights into the regulation of protein phosphatase 2A by small t antigen of SV40.
Chen Y, Xu Y, Bao Q, Xing Y, Li Z, Lin Z, Stock JB, Jeffrey PD, Shi Y

Nature structural & molecular biology. 2007 Jun;14(6):527-34
Crystal structure of the Bcl-XL-Beclin 1 peptide complex: Beclin 1 is a novel BH3-only protein.
Oberstein A, Jeffrey PD, Shi Y

The Journal of biological chemistry. 2007 Apr 27;282(17):13123-32
Structural analysis of a rhomboid family intramembrane protease reveals a gating mechanism for substrate entry.
Wu Z, Yan N, Feng L, Oberstein A, Yan H, Baker RP, Gu L, Jeffrey PD, Urban S, Shi Y

Nature structural & molecular biology. 2006 Dec;13(12):1084-91
Structure of the protein phosphatase 2A holoenzyme.
Xu Y, Xing Y, Chen Y, Chao Y, Lin Z, Fan E, Yu JW, Strack S, Jeffrey PD, Shi Y

Cell. 2006 Dec 15;127(6):1239-51
Structure of protein phosphatase 2A core enzyme bound to tumor-inducing toxins.
Xing Y, Xu Y, Chen Y, Jeffrey PD, Chao Y, Lin Z, Li Z, Strack S, Stock JB, Shi Y

Cell. 2006 Oct 20;127(2):341-53
Ligand-induced asymmetry in histidine sensor kinase complex regulates quorum sensing.
Neiditch MB, Federle MJ, Pompeani AJ, Kelly RC, Swem DL, Jeffrey PD, Bassler BL, Hughson FM

Cell. 2006 Sep 22;126(6):1095-108
Structure and mechanism of the phosphotyrosyl phosphatase activator.
Chao Y, Xing Y, Chen Y, Xu Y, Lin Z, Li Z, Jeffrey PD, Stock JB, Shi Y

Molecular cell. 2006 Aug;23(4):535-46
Crystal structure of a viral FLIP: insights into FLIP-mediated inhibition of death receptor signaling.
Li FY, Jeffrey PD, Yu JW, Shi Y

The Journal of biological chemistry. 2006 Feb 3;281(5):2960-8
Structural basis of competitive recognition of p53 and MDM2 by HAUSP/USP7: implications for the regulation of the p53-MDM2 pathway.
Hu M, Gu L, Li M, Jeffrey PD, Gu W, Shi Y

PLoS biology. 2006 Feb;4(2):e27
Structure and mechanisms of the proteasome-associated deubiquitinating enzyme USP14.
Hu M, Li P, Song L, Jeffrey PD, Chenova TA, Wilkinson KD, Cohen RE, Shi Y

The EMBO journal. 2005 Nov 2;24(21):3747-56
Acquired resistance to imatinib in gastrointestinal stromal tumor occurs through secondary gene mutation.
Antonescu CR, Besmer P, Guo T, Arkun K, Hom G, Koryotowski B, Leversha MA, Jeffrey PD, Desantis D, Singer S, Brennan MF, Maki RG, DeMatteo RP

Clinical cancer research : an official journal of the American Association for Cancer Research. 2005 Jun 1;11(11):4182-90
Structural basis for inhibition of the epidermal growth factor receptor by cetuximab.
Li S, Schmitz KR, Jeffrey PD, Wiltzius JJ, Kussie P, Ferguson KM

Cancer cell. 2005 Apr;7(4):301-11
Structural differences in the DNA binding domains of human p53 and its C. elegans ortholog Cep-1.
Huyen Y, Jeffrey PD, Derry WB, Rothman JH, Pavletich NP, Stavridi ES, Halazonetis TD

Structure (London, England : 1993). 2004 Jul;12(7):1237-43
Repelling class discrimination: ephrin-A5 binds to and activates EphB2 receptor signaling.
Himanen JP, Chumley MJ, Lackmann M, Li C, Barton WA, Jeffrey PD, Vearing C, Geleick D, Feldheim DA, Boyd AW, Henkemeyer M, Nikolov DB

Nature neuroscience. 2004 May;7(5):501-9
Crystal structure of a human Mob1 protein: toward understanding Mob-regulated cell cycle pathways.
Stavridi ES, Harris KG, Huyen Y, Bothos J, Verwoerd PM, Stayrook SE, Pavletich NP, Jeffrey PD, Luca FC

Structure (London, England : 1993). 2003 Sep;11(9):1163-70
Structure and axon outgrowth inhibitor binding of the Nogo-66 receptor and related proteins.
Barton WA, Liu BP, Tzvetkova D, Jeffrey PD, Fournier AE, Sah D, Cate R, Strittmatter SM, Nikolov DB

The EMBO journal. 2003 Jul 1;22(13):3291-302
Structure of a beta-TrCP1-Skp1-beta-catenin complex: destruction motif binding and lysine specificity of the SCF(beta-TrCP1) ubiquitin ligase.
Wu G, Xu G, Schulman BA, Jeffrey PD, Harper JW, Pavletich NP

Molecular cell. 2003 Jun;11(6):1445-56

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