Epernicus: Patrick Allard, Ph.D.

Patrick Allard, Ph.D.

Position:
Post Doctoral Fellow

Genetics

Harvard Medical School (Boston, MA)
Advisor:
Clifford J. Tabin
Degrees:

Ph.D., Biology, McGill University (Montreal, Canada)
Past Advisors:

Hugh J Clarke (as Graduate Student - Ph.D.)

Jean-Marie Delabar (as Graduate Student - Masters)
Research:
C. elegans as a model system to understand environmental influence on germline health

Environmental exposure is a major contributor to the etiology of diseases such as cancer and infertility. However, the dissection of the affected molecular pathways has been particularly challenging. We propose to use the worm C. elegans to investigate the genetic mechanisms of germline health disruption following environmental exposure.
Honors:
2005 Dean's Honors list

Communities:

Patrick Allard's Genealogy

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Patrick Allard's Publications (8)

Mechanistic insights into the action of Bisphenol A on the germline using C. elegans.
Allard P, Colaiácovo MP

Cell cycle (Georgetown, Tex.). 2011 Jan 15;10(2)
Bisphenol A impairs the double-strand break repair machinery in the germline and causes chromosome abnormalities.
Allard P, Colaiácovo MP

Proceedings of the National Academy of Sciences of the United States of America. 2010 Nov 23;107(47):20405-10
Proteasomal activity is required to initiate and to sustain translational activation of messenger RNA encoding the stem-loop-binding protein during meiotic maturation in mice.
Yang Q, Allard P, Huang M, Zhang W, Clarke HJ

Biology of reproduction. 2010 Jan;82(1):123-31
Achieving bilateral symmetry during vertebrate limb development.
Allard P, Tabin CJ

Seminars in cell & developmental biology. 2009 Jun;20(4):479-84
Characterization of a novel ectodermal signaling center regulating Tbx2 and Shh in the vertebrate limb.
Nissim S, Allard P, Bandyopadhyay A, Harfe BD, Tabin CJ

Developmental biology. 2007 Apr 1;304(1):9-21
Clast4, the murine homologue of human eIF4E-Transporter, is highly expressed in developing oocytes and post-translationally modified at meiotic maturation.
Villaescusa JC, Allard P, Carminati E, Kontogiannea M, Talarico D, Blasi F, Farookhi R, Verrotti AC

Gene. 2006 Feb 15;367:101-9
The stem-loop binding protein regulates translation of histone mRNA during mammalian oogenesis.
Allard P, Yang Q, Marzluff WF, Clarke HJ

Developmental biology. 2005 Oct 1;286(1):195-206
Stem-loop binding protein accumulates during oocyte maturation and is not cell-cycle-regulated in the early mouse embryo.
Allard P, Champigny MJ, Skoggard S, Erkmann JA, Whitfield ML, Marzluff WF, Clarke HJ

Journal of cell science. 2002 Dec 1;115(Pt 23):4577-86

Patrick Allard's Posters and Presentations (4)

C. elegans as a model system to understand environmental influence on germline health (poster)
Patrick Allard

International C. elegans meeting; 06/2009
Stem-Loop Binding Protein accumulation during meiotic maturation is required for normal histone synthesis and embryonic chromatin assembly. (presentation)
Patrick Allard

Annual Ottawa Reproductive Workshop; 05/2005
Use of RNAi to investigate the function of SLBP during mouse oogenesis (presentation)
Patrick Allard

Quebec Regional Reproduction Research Meeting. ; 10/2003
Use of RNAi to investigate the function of SLBP during mouse oogenesis (presentation)
Patrick Allard

Montreal Area Reproduction and Developmental Biology Meeting; 11/2002

One Figure

Male specific GFP reporter in C. elegans

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