Epernicus: Olivia M Merkel, Ph.D.

Olivia M Merkel, Ph.D.

Position:
Assistant Professor

Department of Pharmaceutical Sciences

Wayne State University (Detroit, MI)
Degrees:

Ph.D., Pharmaceutucs, University of Marburg (Marburg, Germany)

M.S., Biopharmacy, University of Marburg (Marburg, Germany), Martin Luther University of Halle-Wittenberg (Halle, Germany)
Past Advisors:

Thomas Kissel (as Graduate Student - Ph.D.)
Research:

Communities:

Olivia Merkel's Genealogy

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Olivia Merkel's Publications (25)

Pulmonary Gene Delivery Using Polymeric Nonviral Vectors.
Merkel OM, Zheng M, Debus H, Kissel T

Bioconjugate chemistry. 2011 Nov 1
Nonviral Pulmonary Delivery of siRNA.
Merkel OM, Kissel T

Accounts of chemical research. 2011 Sep 9
PEGylated poly(ethylene imine) copolymer-delivered siRNA inhibits HIV replication in vitro.
Weber ND, Merkel OM, Kissel T, Muñoz-Fernández MA

Journal of controlled release : official journal of the Controlled Release Society. 2011 Sep 10
Biophysical characterization of hyper-branched polyethylenimine-graft-polycaprolactone-block-mono-methoxyl-poly(ethylene glycol) copolymers (hy-PEI-PCL-mPEG) for siRNA delivery.
Liu Y, Samsonova O, Sproat B, Merkel O, Kissel T

Journal of controlled release : official journal of the Controlled Release Society. 2011 Aug 10;153(3):262-8
Biodegradable poly(ethylene carbonate) nanoparticles as a promising drug delivery system with "stealth" potential.
Bege N, Renette T, Jansch M, Reul R, Merkel O, Petersen H, Curdy C, Müller RH, Kissel T

Macromolecular bioscience. 2011 Jul 7;11(7):897-904
In vitro and in vivo complement activation and related anaphylactic effects associated with polyethylenimine and polyethylenimine-graft-poly(ethylene glycol) block copolymers.
Merkel OM, Urbanics R, Bedocs P, Rozsnyay Z, Rosivall L, Toth M, Kissel T, Szebeni J

Biomaterials. 2011 Jul;32(21):4936-42
Molecular modeling and in vivo imaging can identify successful flexible triazine dendrimer-based siRNA delivery systems.
Merkel OM, Zheng M, Mintzer MA, Pavan GM, Librizzi D, Maly M, Höffken H, Danani A, Simanek EE, Kissel T

Journal of controlled release : official journal of the Controlled Release Society. 2011 Jul 15;153(1):23-33
Amphiphilic and biodegradable hy-PEI-g-PCL-b-PEG copolymers efficiently mediate transgene expression depending on their graft density.
Zheng M, Liu Y, Samsonova O, Endres T, Merkel O, Kissel T

International journal of pharmaceutics. 2011 May 12
Comparative in vivo study of poly(ethylene imine)/siRNA complexes for pulmonary delivery in mice.
Beyerle A, Braun A, Merkel O, Koch F, Stoeger T, Kissel T

Journal of controlled release : official journal of the Controlled Release Society. 2011 Apr 10;151(1):51-6
Polymer-related off-target effects in non-viral siRNA delivery.
Merkel OM, Beyerle A, Beckmann BM, Zheng M, Hartmann RK, Stöger T, Kissel TH

Biomaterials. 2011 Mar;32(9):2388-98
Low Molecular Weight pDMAEMA-block-pHEMA Block-Copolymers Synthesized via RAFT-Polymerization: Potential Non-Viral Gene Delivery Agents?
Olga Samsonova, Christian Pfeiffer, Markus Hellmund, Olivia M Merkel, Thomas Kissel

Polymers. 2011;3:693-718
Triazine dendrimers as nonviral vectors for in vitro and in vivo RNAi: the effects of peripheral groups and core structure on biological activity.
Merkel OM, Mintzer MA, Librizzi D, Samsonova O, Dicke T, Sproat B, Garn H, Barth PJ, Simanek EE, Kissel T

Molecular pharmaceutics. 2010 Aug 2;7(4):969-83
Computational insights into the interactions between DNA and siRNA with "rigid" and "flexible" triazine dendrimers.
Pavan GM, Mintzer MA, Simanek EE, Merkel OM, Kissel T, Danani A

Biomacromolecules. 2010 Mar 8;11(3):721-30
PEGylation affects cytotoxicity and cell-compatibility of poly(ethylene imine) for lung application: structure-function relationships.
Beyerle A, Merkel O, Stoeger T, Kissel T

Toxicology and applied pharmacology. 2010 Jan 15;242(2):146-54
Perfectly shaped siRNA delivery
Olivia M Merkel, Meredith A Mintzer, Eric E Simanek, Thomas Kissel

Therapeutic Delivery. 2010;1(6):737-742
Stability of siRNA polyplexes from poly(ethylenimine) and poly(ethylenimine)-g-poly(ethylene glycol) under in vivo conditions: effects on pharmacokinetics and biodistribution measured by Fluorescence Fluctuation Spectroscopy and Single Photon Emission Com
Merkel OM, Librizzi D, Pfestroff A, Schurrat T, Buyens K, Sanders NN, De Smedt SC, Béhé M, Kissel T

Journal of controlled release : official journal of the Controlled Release Society. 2009 Sep 1;138(2):148-59
Triazine dendrimers as nonviral gene delivery systems: effects of molecular structure on biological activity.
Merkel OM, Mintzer MA, Sitterberg J, Bakowsky U, Simanek EE, Kissel T

Bioconjugate chemistry. 2009 Sep;20(9):1799-806
Integrin alphaVbeta3 targeted gene delivery using RGD peptidomimetic conjugates with copolymers of PEGylated poly(ethylene imine).
Merkel OM, Germershaus O, Wada CK, Tarcha PJ, Merdan T, Kissel T

Bioconjugate chemistry. 2009 Jun;20(6):1270-80
In vivo pharmacokinetics, tissue distribution and underlying mechanisms of various PEI(-PEG)/siRNA complexes.
Malek A, Merkel O, Fink L, Czubayko F, Kissel T, Aigner A

Toxicology and applied pharmacology. 2009 Apr 1;236(1):97-108
In vivo SPECT and real-time gamma camera imaging of biodistribution and pharmacokinetics of siRNA delivery using an optimized radiolabeling and purification procedure.
Merkel OM, Librizzi D, Pfestroff A, Schurrat T, Béhé M, Kissel T

Bioconjugate chemistry. 2009 Jan;20(1):174-82
A new synthesis method and degradation of hyper-branched polyethylenimine grafted polycaprolactone block mono-methoxyl poly (ethylene glycol) copolymers (hy-PEI-g-PCL-b-mPEG) as potential DNA delivery vectors
Yu Liu, Juniane Nguyen, Terry Steele, Olivia M Merkel, Thomas Kissel

Polymer. 2009;50(16):3895-3904
Nonviral siRNA delivery to the lung: investigation of PEG-PEI polyplexes and their in vivo performance.
Merkel OM, Beyerle A, Librizzi D, Pfestroff A, Behr TM, Sproat B, Barth PJ, Kissel T

Molecular pharmaceutics. 2009 Jul-Aug;6(4):1246-60
Polycationic triazine-based dendrimers: effect of peripheral groups on transfection efficiency.
Mintzer MA, Merkel OM, Kissel T, Simanek EE

New journal of chemistry = Nouveau journal de chimie. 2009;33:1918-1925
Fast degrading polyesters as siRNA nano-carriers for pulmonary gene therapy.
Nguyen J, Steele TW, Merkel O, Reul R, Kissel T

Journal of controlled release : official journal of the Controlled Release Society. 2008 Dec 18;132(3):243-51
Influence of polyethylene glycol chain length on the physicochemical and biological properties of poly(ethylene imine)-graft-poly(ethylene glycol) block copolymer/SiRNA polyplexes.
Mao S, Neu M, Germershaus O, Merkel O, Sitterberg J, Bakowsky U, Kissel T

Bioconjugate chemistry. 2006 Sep-Oct;17(5):1209-18

One Figure

Knockdown of EGFP expression in EGFP mice after intratracheal instillation of PEG-PEI/siRNA, see Merkel et al, Mol Pharm 2009

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