Nicholas P Tucker

Nicholas P Tucker, Ph.D.

  • Positions:
    Lecturer in Medical Microbiology

    Strathclyde Institute of Pharmacy and Biomedical Science

    University of Strathclyde (Glasgow, UK)

    Post Doctoral Fellow

    Molecular Microbiology

    The John Innes Centre (Norwich, UK)

  •  
  • Advisor:

    Ray A Dixon

  •  
  • Degrees:
     
    Ph.D., Molecular Microbiology, The John Innes Centre (Norwich, UK), University of East Anglia (Norwich, UK)
     
    M.Sc., Human Molecular Genetics, Imperial College London (London, United Kingdom)
     
    B.Sc., Biochemistry, Heriot-Watt University Edinburgh (Scotland, United Kingdom)
  •  
  • Past Advisors:
     
    Ray A Dixon (as Graduate Student - Ph.D.)
     
    Stephen Spiro (as Graduate Student - Ph.D.)
  •  
  • Research:
    Bacterial response to nitrosative stress, particularly nitric oxide sensing transcription factors.

    Nitric oxide is a toxic radical gas that is produced by macrophage cells as a broad range antibiotic. Bacterial pathogens have evolved a number of systems for detoxifying nitric oxide such as flavorubredoxin and flavohemoglobin in E. coli. The expression of the genes encoding these proteins is nitric oxide dependent and is controlled by the transcriptional regulators NorR and NsrR respectively. Both proteins sense nitric oxide via metal centres which control their ability to activate or repress gene expression.

  •  
  • Other Experience:

    2000-2001 Research Technician, Imperial College

Life Sciences
Communities:

Nicholas Tucker's Genealogy

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Nicholas Tucker's Publications (14)



Nicholas Tucker's Posters and Presentations (6)

  • Bacterial responses to nitrosative stress. (presentation)

    Nicholas P Tucker

    Bacterial Networks 2008, Sant Feliu de Guixols, Spain., ESF and EMBO ; 09/2008
  • NO sensing by the transcriptional regulator NorR (presentation)

    Nicholas P. Tucker, Benoit D’Autréaux, Stephen Spiro and Ray Dixon.

    12th European Nitrogen Cycle Meeting; University of York; 09/2007
  • A novel non-haem iron centre senses nitric oxide in Escherichia coli NorR. (presentation)

    Nicholas P. Tucker, Benoit D’Autréaux, Stephen Spiro and Ray Dixon.

    62nd Harden Conference (Biochemical Society) - NO; a radical in control, Biochemical Society; 04/2006
  • Role of three enhancer sites in σ54-dependent transcription by the nitric oxide sensing regulatory protein NorR. (presentation)

    Nicholas P Tucker and Ray Dixon

    18th RNA Polymerase workshop, University of Birmingham, Biochemical Society; 03/2006
  • Mutagenesis of the Escherichia coli nitric oxide sensor NorR and its DNA target sequences. (presentation)

    Nicholas P. Tucker, Benoit D’Autréaux, Stephen Spiro and Ray Dixon.

    11th European Nitrogen Cycle Meeting; Granada, Spain; 09/2005
  • DNA binding properties of the Escherichia coli nitric oxide sensor NorR: towards an understanding of the regulation of flavorubredoxin. (presentation)

    Nicholas P Tucker

    10th European Nitrogen Cycle Meeting: Norwich, UK , Biochemical Society; 09/2004

One Figure

One Figure for Nicholas P Tucker

Nitric oxide dependent gene regulation by NorR from E. coli.


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