Manoj Tyagi

Manoj Tyagi, Ph.D.

  • Position:
    Post Doctoral REsearch Associate

    Anatomy and Neurobiology

    University of Maryland, Baltimore (Baltimore, MD)

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  • Advisor:

    Frank L. Margolis

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  • Degrees:
     
    Ph.D., Medical Biochemistry, Vallabhbhai Patel Chest Institute (Delhi, India)
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  • Past Advisors:
     
    William T Gerthoffer (as Post Doctoral Fellow)
     
    Surendra K Bansal (as Graduate Student - Ph.D.)
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  • Research:
    • Cellular / Molecular biology
    • Olfaction/ Chemosensory and Neurobiology
    • PKC and PKA signaling in inflammatory diseases
    • Enzyme characterization, enzyme kinetics and assay development
    • Self motivated / innovative strategically minded, result oriented well organized problem solver with good interpersonal skills.

    My current work is mainly focused on Olfactory Marker Protein (OMP) which is proposed to be a key member of Calmodulin (CaM) regulatory process in olfactory transduction. I am currently addressing the hypothesis: The Na/ Ca exchanger (NCX) activity the returns elevated intracellular Ca to prestimulus levels in OSN is modulated by intracellular interactions among OMP, CaM, and Bex1. I am also looking for OMP's unknown functional aspects ; influence of OMP on NCX activity, total cAMP generation and co-transporters (NKCC1) based analysis in Olfactory cilia. These coordinated analysis will provide a new insights to molecular mechanisms by which the olfactory transduction cascade is regulated and will broad impact on understanding OMP influenced CaM regulation of olfactory signal transduction.

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  • Other Experience:

    2010-present Associate Editor J Biochemical Letter - Bioinfo press

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  • Honors:

    2010-present Member editorial board Cell health and cytoskeleton, (Dove press, New Zealand)

    2008-present Member editorial board, J biochemical technology (sevas India).

    2007-present Editorial Member: Therapeutic advances in respiratory disorders (Sage pub. UK)

    2007-present Member editorial Board, J for biochemistry (SJI California, USA).

Life Sciences
Communities:

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Manoj Tyagi's Publications (5)



Manoj Tyagi's Posters and Presentations (3)

  • Role of Olfactory Marker Protein in Regulation of Na-Ca exchange activity in olfactory cilia of WT, OMP-KO and Bex1-KO mice. AChems annual meeting (2011) (poster)

    Manoj Tyagi, Joyce Margolis, Frank L. Margolis.

    AChems annual meeting (2011), 83 (18): P#274.; 04/2011
  • Regulation of Sodium Calcium Exchanger (NCX) activity by Calmodulin or Olfactory Marker Protein (OMP) in olfactory signaling transduction cascade. (poster)

    Manoj Tyagi, Frank L Margolis.

    Association of Chemoreception Sciences, ACHEMS 2010 annual meeting; 04/2010
  • 14-3-3 PROTEINS AND REGULATION OF INTRACELLULAR SIGNALING IN AIRWAY SMOOTH MUSCLE CONTRACTION. (presentation)

    Tyagi M, Pannell L K and Gerthoffer W T,

    GPLIS Meeting UMD Baltimore, Annual Meeting; 03/2009
    Attachment: Abstract.pptx

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