Epernicus: Melanie M Pearson, Ph.D.

Melanie M Pearson, Ph.D.

Position:
Assistant Professor

Microbiology

Urology

New York University School of Medicine (New York, NY)
Degrees:

Ph.D., Molecular Microbiology, University of Texas Southwestern Medical Center (Dallas, TX)

B.S., Biomedical Sciences, Western Michigan University (Kalamazoo, MI)
Past Advisors:

Harry L.T. Mobley (as Post Doctoral Fellow)

Eric J. Hansen (as Graduate Student - Ph.D.)

Silvia Rossbach (as Undergraduate Student)
Research:
Virulence factors of the urinary tract pathogen Proteus mirabilis

My research focuses on the bacterial urinary tract pathogen Proteus mirabilis. My published work includes the sequence and annotation of our type strain genome, discovery of a type III secretion system in P. mirabilis, detailed analysis of a mechanism P. mirabilis uses for fimbrial control of flagellar expression, and investigation of oxygen regulation of fimbrial expression. Current projects include use of microarrays to study swarming motility and transcriptome analysis of P. mirabilis isolated from the urine of experimentally-infected mice.

Communities:

Melanie Pearson's Genealogy

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Melanie Pearson's Publications (11)

Transcriptome of swarming Proteus mirabilis.
Pearson MM, Rasko DA, Smith SN, Mobley HL

Infection and immunity. 2010 Jun;78(6):2834-45
Oxygen-limiting conditions enrich for fimbriate cells of uropathogenic Proteus mirabilis and Escherichia coli.
Lane MC, Li X, Pearson MM, Simms AN, Mobley HL

Journal of bacteriology. 2009 Mar;191(5):1382-92
Repression of motility during fimbrial expression: identification of 14 mrpJ gene paralogues in Proteus mirabilis.
Pearson MM, Mobley HL

Molecular microbiology. 2008 Jul;69(2):548-58
Complete genome sequence of uropathogenic Proteus mirabilis, a master of both adherence and motility.
Pearson MM, Sebaihia M, Churcher C, Quail MA, Seshasayee AS, Luscombe NM, Abdellah Z, Arrosmith C, Atkin B, Chillingworth T, Hauser H, Jagels K, Moule S, Mungall K, Norbertczak H, Rabbinowitsch E, Walker D, Whithead S, Thomson NR, Rather PN, Parkhill J, Mobley HL

Journal of bacteriology. 2008 Jun;190(11):4027-37
Metabolic analysis of Moraxella catarrhalis and the effect of selected in vitro growth conditions on global gene expression.
Wang W, Reitzer L, Rasko DA, Pearson MM, Blick RJ, Laurence C, Hansen EJ

Infection and immunity. 2007 Oct;75(10):4959-71
The type III secretion system of Proteus mirabilis HI4320 does not contribute to virulence in the mouse model of ascending urinary tract infection.
Pearson MM, Mobley HL

Journal of medical microbiology. 2007 Oct;56(Pt 10):1277-83
Identification of gene products involved in biofilm production by Moraxella catarrhalis ETSU-9 in vitro.
Pearson MM, Hansen EJ

Infection and immunity. 2007 Sep;75(9):4316-25
A UspA2H-negative variant of Moraxella catarrhalis strain O46E has a deletion in a homopolymeric nucleotide repeat common to uspA2H genes.
Wang W, Pearson MM, Attia AS, Blick RJ, Hansen EJ

Infection and immunity. 2007 Apr;75(4):2035-45
Biofilm formation by Moraxella catarrhalis in vitro: roles of the UspA1 adhesin and the Hag hemagglutinin.
Pearson MM, Laurence CA, Guinn SE, Hansen EJ

Infection and immunity. 2006 Mar;74(3):1588-96
A hag mutant of Moraxella catarrhalis strain O35E is deficient in hemagglutination, autoagglutination, and immunoglobulin D-binding activities.
Pearson MM, Lafontaine ER, Wagner NJ, St Geme JW, Hansen EJ

Infection and immunity. 2002 Aug;70(8):4523-33
Cadmium-regulated gene fusions in Pseudomonas fluorescens.
Rossbach S, Kukuk ML, Wilson TL, Feng SF, Pearson MM, Fisher MA

Environmental microbiology. 2000 Aug;2(4):373-82

Melanie Pearson's Posters and Presentations (7)

Transcriptome Analysis of Proteus mirabilis Swarmer Cells (poster)
Melanie M Pearson, David A Rasko, and Harry L.T. Mobley

Gordon Conference on Microbial Toxins and Pathogenicity; 07/2008
Identification of Fourteen Additional MrpJ-like Fimbrial Proteins That Are Regulators of Motility in Proteus mirabilis (poster)
Melanie M Pearson and Harry L.T. Mobley

American Society for Microbiology, 107th General Meeting- Toronto, ONT; 05/2007
The Complete Genome Sequence of Proteus mirabilis, an Etiologic Agent of Complicated Urinary Tract Infection (poster)
Melanie M Pearson, Mohammed Sebaihia, Julian Parkhill, and Harry L.T. Mobley

American Society for Microbiology, 106th General Meeting- Orlando, FL; 05/2006
UspA2H is Involved in Biofilm Formation by Moraxella catarrhalis Strain ETSU-9 (poster)
Melanie M Pearson and Eric J Hansen

American Society for Microbiology, 104th General Meeting- New Orleans, LA; 05/2004
Genetic Analysis of Biofilm Formation by Moraxella catarrhalis (poster)
Melanie M Pearson and Eric J. Hansen

American Society for Microbiology, 103rd General Meeting-Washington, DC; 05/2003
Construction and Analysis of a hag Mutant of Moraxella catarrhalis Strain O35E (poster)
Melanie M Pearson and Eric J. Hansen

American Society for Microbiology, 102nd General Meeting- Salt Lake City, UT; 05/2002
Two Methods for Studying Biofilm Formation by Moraxella catarrhalis (poster)
Melanie M Pearson and Eric J. Hansen

European Research Conference on Bacterial Interactions with Mucus and Mucosa, Canterbury, UK; 09/2001

Websites

Mobley lab

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