Epernicus: Marc Lafleur, Ph.D.

Marc Lafleur, Ph.D.

Position:
scientist

Investigative toxicology

Amgen, Inc. (Thousand Oaks, CA)
Degrees:

Ph.D., Biological Sciences, University of East Anglia (Norwich, UK)

B.Sc., Biotechnology, University of Ottawa (Ottawa, Canada)
Past Advisors:

Martin Hemler (as Post Doctoral Fellow)
Research:
Other Experience:
2005-2008 Postdoctoral fellow - Harvard Medical School and Dana-Farber Cancer Institute - Boston MA

2001-2005 Postdoctoral fellow - St. Vincent's Institute - Melbourne, Australia

Communities:

Marc Lafleur's Genealogy

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Marc Lafleur's Publications (13)

Tetraspanin proteins regulate membrane type-1 matrix metalloproteinase-dependent pericellular proteolysis.
Lafleur MA, Xu D, Hemler ME

Molecular biology of the cell. 2009 Apr;20(7):2030-40
Glioblastoma inhibition by cell surface immunoglobulin protein EWI-2, in vitro and in vivo.
Kolesnikova TV, Kazarov AR, Lemieux ME, Lafleur MA, Kesari S, Kung AL, Hemler ME

Neoplasia (New York, N.Y.). 2009 Jan;11(1):77-86, 4p following 86
The type I collagen induction of MT1-MMP-mediated MMP-2 activation is repressed by alphaVbeta3 integrin in human breast cancer cells.
Borrirukwanit K, Lafleur MA, Mercuri FA, Blick T, Price JT, Fridman R, Pereira JJ, Leardkamonkarn V, Thompson EW

Matrix biology : journal of the International Society for Matrix Biology. 2007 May;26(4):291-305
Type I collagen abrogates the clathrin-mediated internalization of membrane type 1 matrix metalloproteinase (MT1-MMP) via the MT1-MMP hemopexin domain.
Lafleur MA, Mercuri FA, Ruangpanit N, Seiki M, Sato H, Thompson EW

The Journal of biological chemistry. 2006 Mar 10;281(10):6826-40
Upregulation of matrix metalloproteinases (MMPs) in breast cancer xenografts: a major induction of stromal MMP-13.
Lafleur MA, Drew AF, de Sousa EL, Blick T, Bills M, Walker EC, Williams ED, Waltham M, Thompson EW

International journal of cancer. Journal international du cancer. 2005 Apr 20;114(4):544-54
Correlation of tumor- and stromal-derived MT1-MMP expression with progression of human ovarian tumors in SCID mice.
Drew AF, Blick TJ, Lafleur MA, Tim EL, Robbie MJ, Rice GE, Quinn MA, Thompson EW

Gynecologic oncology. 2004 Dec;95(3):437-48
Selective involvement of TIMP-2 in the second activational cleavage of pro-MMP-2: refinement of the pro-MMP-2 activation mechanism.
Lafleur MA, Tester AM, Thompson EW

FEBS letters. 2003 Oct 23;553(3):457-63
Metalloproteinases and their inhibitors in angiogenesis.
Lafleur MA, Handsley MM, Edwards DR

Expert reviews in molecular medicine. 2003 Sep;5(23):1-39
Endothelial tubulogenesis within fibrin gels specifically requires the activity of membrane-type-matrix metalloproteinases (MT-MMPs).
Lafleur MA, Handsley MM, Knäuper V, Murphy G, Edwards DR

Journal of cell science. 2002 Sep 1;115(Pt 17):3427-38
Activation of pro-(matrix metalloproteinase-2) (pro-MMP-2) by thrombin is membrane-type-MMP-dependent in human umbilical vein endothelial cells and generates a distinct 63 kDa active species.
Lafleur MA, Hollenberg MD, Atkinson SJ, Knäuper V, Murphy G, Edwards DR

The Biochemical journal. 2001 Jul 1;357(Pt 1):107-15
Differential expression and localization of TIMP-1 and TIMP-4 in human gliomas.
Groft LL, Muzik H, Rewcastle NB, Johnston RN, Knäuper V, Lafleur MA, Forsyth PA, Edwards DR

British journal of cancer. 2001 Jul 6;85(1):55-63
Perivascular cells regulate endothelial membrane type-1 matrix metalloproteinase activity.
Lafleur MA, Forsyth PA, Atkinson SJ, Murphy G, Edwards DR

Biochemical and biophysical research communications. 2001 Mar 30;282(2):463-73
Monitoring MMP and TIMP mRNA expression by RT-PCR.
Wong H, Muzik H, Groft LL, Lafleur MA, Matouk C, Forsyth PA, Schultz GA, Wall SJ, Edwards DR

Methods in molecular biology (Clifton, N.J.). 2001;151:305-20

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