Epernicus: Matteo Iannacone, M.D., Ph.D.

Matteo Iannacone, M.D., Ph.D.

Positions:
Group Leader

Immunology, Infectious Diseases and Transplantation

San Raffaele Scientific Institute

Post Doctoral Fellow

Pathology

Harvard Medical School (Boston, MA)
Degrees:

Ph.D., Immunology, Vita-Salute San Raffaele University (Milan, Italy)

M.D., Medicine and Surgery, University of Milan (Milan, Italy)
Clinical Training:

Residency, Internal Medicine, Scientific Institute San Raffaele
Past Advisors:

Ulrich H. von Andrian (as Post Doctoral Fellow)

Luca G Guidotti (as Post Doctoral Fellow)

Francis V Chisari (as Post Doctoral Fellow)
Research:
Viral Immunology

We are mainly interested in:
1) How viruses are handled within draining lymph nodes upon peripheral inoculation and how antiviral immune responses are generated
2) Dissecting the cellular and molecular mechanism underlying T cell mediated immunopathology in the liver in the context of chronic viral hepatitis
Honors:
2008-present Recipient of U.S. Permanent Residency as a Scientist of Extraordinary Ability

2008-present Armenise-Harvard Fellow

Communities:

Matteo Iannacone's Genealogy

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Matteo Iannacone's Publications (14)

Subcapsular sinus macrophages prevent CNS invasion on peripheral infection with a neurotropic virus.
Iannacone M, Moseman EA, Tonti E, Bosurgi L, Junt T, Henrickson SE, Whelan SP, Guidotti LG, von Andrian UH

Nature. 2010 Jun 24;465(7301):1079-83
On the role of platelets in the pathogenesis of viral hepatitis.
Iannacone M, Sitia G, Guidotti LG

Journal of hepatology. 2009 Sep;51(3):599-600
Platelets prevent IFN-alpha/beta-induced lethal hemorrhage promoting CTL-dependent clearance of lymphocytic choriomeningitis virus.
Iannacone M, Sitia G, Isogawa M, Whitmire JK, Marchese P, Chisari FV, Ruggeri ZM, Guidotti LG

Proceedings of the National Academy of Sciences of the United States of America. 2008 Jan 15;105(2):629-34
Acute thrombocytopenia after liver transplant: role of platelet activation, thrombopoietin deficiency and response to high dose intravenous IgG treatment.
Nascimbene A, Iannacone M, Brando B, De Gasperi A

Journal of hepatology. 2007 Nov;47(5):651-7
Antiplatelet drug therapy moderates immune-mediated liver disease and inhibits viral clearance in mice infected with a replication-deficient adenovirus.
Iannacone M, Sitia G, Narvaiza I, Ruggeri ZM, Guidotti LG

Clinical and vaccine immunology : CVI. 2007 Nov;14(11):1532-5
Subcapsular sinus macrophages in lymph nodes clear lymph-borne viruses and present them to antiviral B cells.
Junt T, Moseman EA, Iannacone M, Massberg S, Lang PA, Boes M, Fink K, Henrickson SE, Shayakhmetov DM, Di Paolo NC, van Rooijen N, Mempel TR, Whelan SP, von Andrian UH

Nature. 2007 Nov 1;450(7166):110-4
HBV pathogenesis in animal models: recent advances on the role of platelets.
Iannacone M, Sitia G, Ruggeri ZM, Guidotti LG

Journal of hepatology. 2007 Apr;46(4):719-26
Treatment with HMGB1 inhibitors diminishes CTL-induced liver disease in HBV transgenic mice.
Sitia G, Iannacone M, Müller S, Bianchi ME, Guidotti LG

Journal of leukocyte biology. 2007 Jan;81(1):100-7
Platelets mediate cytotoxic T lymphocyte-induced liver damage.
Iannacone M, Sitia G, Isogawa M, Marchese P, Castro MG, Lowenstein PR, Chisari FV, Ruggeri ZM, Guidotti LG

Nature medicine. 2005 Nov;11(11):1167-9
HMGB1 is an endogenous immune adjuvant released by necrotic cells.
Rovere-Querini P, Capobianco A, Scaffidi P, Valentinis B, Catalanotti F, Giazzon M, Dumitriu IE, Müller S, Iannacone M, Traversari C, Bianchi ME, Manfredi AA

EMBO reports. 2004 Aug;5(8):825-30
MMPs are required for recruitment of antigen-nonspecific mononuclear cells into the liver by CTLs.
Sitia G, Isogawa M, Iannacone M, Campbell IL, Chisari FV, Guidotti LG

The Journal of clinical investigation. 2004 Apr;113(8):1158-67
The disposal of dying cells in living tissues.
Manfredi AA, Iannacone M, D'Auria F, Rovere-Querini P

Apoptosis : an international journal on programmed cell death. 2002 Apr;7(2):153-61
Reduced expression of the murine p85alpha subunit of phosphoinositide 3-kinase improves insulin signaling and ameliorates diabetes.
Mauvais-Jarvis F, Ueki K, Fruman DA, Hirshman MF, Sakamoto K, Goodyear LJ, Iannacone M, Accili D, Cantley LC, Kahn CR

The Journal of clinical investigation. 2002 Jan;109(1):141-9
Anti-beta2 glycoprotein I antibodies cause inflammation and recruit dendritic cells in platelet clearance.
Bondanza A, Manfredi AA, Zimmermann VS, Iannacone M, Tincani A, Balestrieri G, Sabbadini MG, Querini PR

Thrombosis and haemostasis. 2001 Nov;86(5):1257-63

One Figure

Platelets facilitate the accumulation of CTLs in the infected liver. Inflammation-induced changes of the vessel wall may promote platelet adhesion and activation, which in turn favor the exit of virus-specific CTLs from the bloodstream and their accumulat

Websites

Iannacone Lab Page

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Matteo Iannacone, M.D., Ph.D.

Group Leader

Post Doctoral Fellow

Viral Immunology

Matteo Iannacone's Genealogy

Matteo Iannacone's Publications (14)

One Figure

Websites