Matthew E Jakubik

Matthew E Jakubik, B.Sc.

(Ph.D. in progress)
  • Position:
    Graduate Student - Ph.D.

    Genetics

    Harvard Medical School (Boston, MA)

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  • Advisors:

    Monica P. Colaiacovo, Chao-ting Wu

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  • Degrees:
     
    Ph.D. (in progress), Genetics, Harvard Medical School (Boston, MA)
     
    B.Sc., Biochemistry, Muhlenberg College (Allentown, PA)
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  • Past Advisors:
     
    Keri L Colabroy (as Undergraduate Student)
     
    Adam Fermier (as Research Associate)
     
    Bruce Anderson (as Undergraduate Student)
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  • Research:
    I study homolog pairing-mediated changes to chromatin structure in D. melanogaster.

    The pairing of maternal and paternal homologous chromosomes is a process commonly associated with meiosis; however, it is becoming more apparent that homolog pairing and other interchromosomal interactions are a common occurrence in somatic cells and may play an important role in the regulation of genes and chromatin structure (1, 2). My research will investigate if homolog pairing alters chromatin structure using chromatin mapping and footprinting techniques. Additionally, previous work has shown that homolog pairing is essential for certain trans regulatory interactions in D. melanogaster, namely transvection via enhancer action in trans and transvection via insulator bypass (3, 4). Current models posit that homolog pairing-mediated changes to gene topology are responsible for insulator bypass (4). I will investigate if such topological constraints are responsible for this interaction.

    1) Carter, et al. Long range chromatin regulatory interactions in vivo. Nature Genetics. 2002. 32: 623-626.
    2) Spilianakas, et al. Interchromosomal associations between alternatively expressed loci. Nature. 2005. 435: 637-645.
    3) Lewis, E. The theory and application of a new method of detecting chromosomal rearrangements in Drosophila melanogaster. The American Naturalist. 1954. 93: 225-239.
    4) Morris, et al. Two modes of transvection: Enhancer action in trans and bypass of a chromatin insulator in cis. PNAS. 1998. 95: 10740-10745.

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  • Other Experience:

    2007 Teaching Assistant, BCMP 200

    2005-2006 Inverse GC Technical Team Leader at Johnson and Johnson Pharmaceutical Research and Development

Life Sciences
Communities:

Matthew Jakubik's Genealogy

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Matthew Jakubik's Publications (1)



One Figure

One Figure for Matthew E Jakubik

Model for transvection via insulator bypass.
(From Morris, et al. 1998)


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