Mary E Caldorera-Moore

Mary E Caldorera-Moore, Ph.D.

  • Position:
    Post Doctoral Fellow

    Chemical Engineering

    University of Texas at Austin (Austin, TX)

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  • Advisors:

    Nicholas A Peppas, Li Shi, Krishnendu Roy

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  • Degrees:
     
    Ph.D., Biomedical Engineering, University of Texas at Austin (Austin, TX)
     
    M.S., Biomedical Engineering, University of Texas at Austin (Austin, TX)
     
    B.Sc., Biomedical Engineering, Louisiana Tech University (Ruston, LA)
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  • Past Advisors:
     
    Michael McShane (as Undergraduate Student)
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  • Research:
    Development of Shape Specific, Stimuli-Responsive Drug Delivery Nanocarriers Using Step and Flash Imprint Lithography.

    Top-down nanoimprinting techniques allows high-throughput fabrication of nanoparticles of precise geometries (shape and size). The ability to manipulate geometry and composition of nanoscale carriers is essential for controlling their in-vivo transport, bio-distribution, and release mechanism. My research focuses on the fabrication of monodisperse, shape-specific, biodegradable nanocarriers with an environmentally sensitive component incorporated into the polymer network using Step and Flash Imprint lithography (S-FIL). In this way, drugs can be released from the nanocarriers in the presence of an environmental signal. I have generated uniform nanocarriers sub-50nm in size and also demonstrate encapsulation and controlled release from these nanocarriers, therefore providing a potential means for disease-controlled delivery. The surfaces of these nanocarriers are easily functionalized with cell targeting ligands to create dual targeting-responsive nanocarriers.

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  • Honors:

    2005-present NSF Graduate Student Fellow

Life Sciences
Communities:

Mary Caldorera-Moore's Genealogy

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Mary Caldorera-Moore's Publications (2)



Mary Caldorera-Moore's Posters and Presentations (5)

  • Nanoimprint Fabrication of Shape and Size-Specific, Enzyme- Responsive Nanocarriers for Drug Delivery (poster)

    Mary E Caldorera-Moore, L. Shi, K. Roy

    Biomedical Engineering Society, 2008 Conference, ; 10/2008
  • Fabrication of Shape-Specific, Enzymatically-Triggered Nanoparticles using Nano Imprint Lithography (presentation)

    Mary E Caldorera-Moore

    Society of Biomaterials; 09/2008
  • Step and Flash Imprint Lithography for the Fabrication of Shape-specific, Enzymatically-triggered Drug Nanocarriers (poster)

    Mary E Caldorera-Moore, L.C. Glangchai, L. Shi, K. Roy

    NSTI Nanotech, The Nanotechnology Conference and Trade Show; 06/2008
  • FABRICATION OF SHAPE-SPECIFIC, ENZYMATICALLY-TRIGGERED NANOPARTICLES USING NANO IMPRINT LITHOGRAPHY (presentation)

    Mary E Caldorera-Moore, L. Shi, K. Roy

    Houston Society for Engineering in Medicine and Biology(HSEMB), 15th Annual Conference; 02/2008
  • Nanoimprint lithography for the fabrication of shape-specific, stimuli-responsive drug nanocarriers. (presentation)

    Mary E Caldorera-Moore, L.C. Glangchai, L. Shi, K. Roy

    Biomedical Engineering Society, Annual Conference; 09/2007

One Figure

One Figure for Mary E Caldorera-Moore

S-FIL Fabricated PEGDA nanoparticles: (A-C) SEM images (A) 50nm squares, 100nm scale bar; (B) 200nm triangles, 200nm scale bar; (C-D) Released nanoparticles (C) 400nm, 1μm scale bar, (D) Fluorescence imge of 400nm particles with encapsulated fluorescentl


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