Epernicus: Lea Scheppke, Ph.D.

Lea Scheppke, Ph.D.

Position:
Graduate Student - Ph.D.

Pathology

Biomedical Sciences

University of California, San Diego (San Diego, CA)
Advisor:
David Cheresh
Degrees:

Ph.D., Molecular Pathology, University of California, San Diego (San Diego, CA)

B.A., Molecular Biology, Pomona College (Claremont, CA)
Past Advisors:

Martin Friedlander (as Technician)
Research:
The investigation of Notch effectors in vascular smooth muscle cells that modulate blood vessel maturation.
Other Experience:
2000-2002 AP Science Teacher, Pilgrim School, Los Angeles, CA
Honors:
2010-present NIH/NCI Growth Regulation and Oncogenesis Training Grant

Communities:

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MicroRNA-132-mediated loss of p120RasGAP activates the endothelium to facilitate pathological angiogenesis.
Anand S, Majeti BK, Acevedo LM, Murphy EA, Mukthavaram R, Scheppke L, Huang M, Shields DJ, Lindquist JN, Lapinski PE, King PD, Weis SM, Cheresh DA

Nature medicine. 2010 Aug;16(8):909-14
A role for VEGF as a negative regulator of pericyte function and vessel maturation.
Greenberg JI, Shields DJ, Barillas SG, Acevedo LM, Murphy E, Huang J, Scheppke L, Stockmann C, Johnson RS, Angle N, Cheresh DA

Nature. 2008 Dec 11;456(7223):809-13
Retinal vascular permeability suppression by topical application of a novel VEGFR2/Src kinase inhibitor in mice and rabbits.
Scheppke L, Aguilar E, Gariano RF, Jacobson R, Hood J, Doukas J, Cao J, Noronha G, Yee S, Weis S, Martin MB, Soll R, Cheresh DA, Friedlander M

The Journal of clinical investigation. 2008 Jun;118(6):2337-46
Combination angiostatic therapy completely inhibits ocular and tumor angiogenesis.
Dorrell MI, Aguilar E, Scheppke L, Barnett FH, Friedlander M

Proceedings of the National Academy of Sciences of the United States of America. 2007 Jan 16;104(3):967-72
Three-dimensional in vivo imaging of the mouse intraocular vasculature during development and disease.
Ritter MR, Aguilar E, Banin E, Scheppke L, Uusitalo-Jarvinen H, Friedlander M

Investigative ophthalmology & visual science. 2005 Sep;46(9):3021-6

Notch-mediated expression of integrin αvβ3 on perivascular cells regulates the maturation of newly forming blood vessels (presentation)
Lea Scheppke, Murphy EA, Zarpellon A, Ruggeri ZM, Merkulova A, Byzova TV, Cheresh DA

International Vascular Biology Meeting (IVBM); 06/2010
Notch-mediated expression of integrin αvβ3 on perivascular cells regulates the maturation of newly forming blood vessels (poster)
Lea Scheppke*, Murphy EA, Zarpellon A, Ruggeri ZM, Merkulova A, Byzova TV, Cheresh DA

MD Anderson Cancer Center International Symposium on Anti-Angiogenic Agents; 02/2010
Topically applied Src kinase/VEGFR inhibitor reduces retinal vascular permeability (poster)
Lea Scheppke*, Aguilar E, Dorrell M, Hood J, Soll R, Yee S, and Friedlander M.

Association for Research in Vision and Ophthalmology (ARVO); 05/2006
Src kinase inhibition reduces laser or VEGF induced retinal vascular permeability (poster)
E Aguilar*, RF Gariano, L Scheppke, S Weiss, DA Cheresh, M Friedlander

Association for Research in Vision and Ophthalmology (ARVO); 05/2005
Transduced bone marrow derived cells target brain tumors and express transgene (presentation)
F Barnett*, L Scheppke, H Uusitalo-Jarvinen, J. Yamanouchi, S. Shattil, M. Friedlander

Annual Congress of Neurological Surgeons; 10/2004
Using 4-dimensional in vivo imaging to study vascular diseases of the eye (presentation)
M Friedlander, L Scheppke, E Banin, M Ritter

Association for Research in Vision and Ophthalmology (ARVO); 05/2004

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