Kieran S Hadler

Kieran S Hadler, Ph.D.

(J.D. in progress)
  • Positions:
    Examiner of Patents (2010-present)

    IP Australia - Australian Government

    Research Officer / Tutor (2006-2010)

    School of Chemistry and Molecular Biosciences

    University of Queensland (Brisbane, Australia)

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  • Degrees:
     
    J.D. (in progress), GCAppLaw, University of Queensland (Brisbane, Australia)
     
    Ph.D., Biophysical Chemistry, University of Queensland (Brisbane, Australia)
     
    B.Sc., (Hons I), Chemistry, University of Queensland (Brisbane, Australia)
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  • Past Advisors:
     
    Gary Schenk (as Post Doctoral Fellow)
     
    Lawrence Gahan (as Post Doctoral Fellow)
     
    Graeme R. Hanson (as Graduate Student - Ph.D.)
     
    James A Larrabee (as Graduate Student - Ph.D.)
     
    Alvan Hengge (as Visiting Student)
     
    Mark J Riley (as Graduate Student - Ph.D.)
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  • Research:
    Structural and functional studies of the organophosphate-degrading enzyme E. aerogenes glycerophosphodiesterase

    Glycerophosphodiesterase (GpdQ) is a highly promiscuous, binuclear metallohydrolase that is active towards phosphate monoesters, diesters and organophosphate triesters (which include nerve agents and pesticides). As a result, GpdQ has potential application as a powerful enzymatic bioremediator for the degradation of nerve agent stockpiles and the decontamination of organophosphate-containing water and soil. My research focusses on the catalytic mechanism of GpdQ. A range of kinetic, structural and spectroscopic techniques are employed to probe various aspects of the reaction mechanism. It is hoped that an understanding of the way GpdQ operates may assist in the development of a more efficient and tunable bioremediator.

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  • Other Experience:

    2005-2010 Chemistry/Biochemistry Tutor

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  • Honors:

    2009 Dean's Award for Outstanding Research Higher Degree Thesis

    2009 Alexander von Humboldt Postdoctoral Resarch Fellowship (Declined)

    2007 MG and RA Plowman Postgraduate Fellowship

    2007-2009 Society of Biological Inorganic Chemistry Bursary

    2006-2009 Australian Postgraduate Award

    2006 Valedictorian

    2001-2004 Advanced Studies Program in Science

    2001 Dux of School

Life Sciences
Communities:

Kieran Hadler's Genealogy

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Kieran Hadler's Publications (19)



Kieran Hadler's Posters and Presentations (4)

  • Flexibility enhances the Reactivity of the Bioremediator Glycerophosphodiesterase by Fine-Tuning its Mechanism of Hydrolysis (poster)

    Kieran S Hadler, et al.

    International Conference for Biological Inorganic Chemistry, Nagoya, Japan; 07/2009
  • Substrate-Promoted Formation of a Catalytically Competent Binuclear Centre in the Glycerophosphodiesterase from Enterobacter aerogenes (poster)

    Kieran S Hadler, et al.

    Lorne Proteins Conference, Lorne, Australia; 01/2009
  • Characterisation of the Physicochemical Properties of Cobalt Substituted E. aerogenes Glycerophosphodiesterase (poster)

    Kieran S Hadler, et al.

    International Conference for Biological Inorganic Chemistry, Vienna, Austria; 07/2007
  • Characterisation of the Physicochemical Properties of Cobalt Substituted E. aerogenes Glycerophosphodiesterase (poster)

    Kieran S Hadler, et al.

    International EPR Symposium, Breckenridge, USA.; 07/2007

One Figure

One Figure for Kieran S Hadler

GpdQ


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