Epernicus: Kathryn L Kavanagh, Ph.D.

Kathryn L Kavanagh, Ph.D.

Position:
Principal Investigator

Structural Genomics Consortium

University of Oxford (Oxford, UK)
Degrees:

Ph.D., Biochemistry and Molecular Biology, University of California, Davis (Davis, CA)

B.S., Chemical Engineering , Texas A&M University (College Station, TX)
Past Advisors:

Udo Oppermann (as Senior Scientist)

David K. Wilson (as Post Doctoral Fellow)

David K. Wilson (as Graduate Student - Ph.D.)
Research:
Determining crystal structures of human metabolic enzymes

Communities:

Kathryn Kavanagh's Genealogy

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Kathryn Kavanagh's Publications (28)

Structure-activity relationships of human AKR-type oxidoreductases involved in bile acid synthesis: AKR1D1 and AKR1C4.
Lee WH, Lukacik P, Guo K, Ugochukwu E, Kavanagh KL, Marsden B, Oppermann U

Molecular and cellular endocrinology. 2009 Mar 25;301(1-2):199-204
The SDR (short-chain dehydrogenase/reductase and related enzymes) nomenclature initiative.
Persson B, Kallberg Y, Bray JE, Bruford E, Dellaporta SL, Favia AD, Duarte RG, Jörnvall H, Kavanagh KL, Kedishvili N, Kisiela M, Maser E, Mindnich R, Orchard S, Penning TM, Thornton JM, Adamski J, Oppermann U

Chemico-biological interactions. 2009 Mar 16;178(1-3):94-8
Medium- and short-chain dehydrogenase/reductase gene and protein families : the SDR superfamily: functional and structural diversity within a family of metabolic and regulatory enzymes.
Kavanagh KL, Jörnvall H, Persson B, Oppermann U

Cellular and molecular life sciences : CMLS. 2008 Dec;65(24):3895-906
Targeting a uniquely nonspecific prenyl synthase with bisphosphonates to combat cryptosporidiosis.
Artz JD, Dunford JE, Arrowood MJ, Dong A, Chruszcz M, Kavanagh KL, Minor W, Russell RG, Ebetino FH, Oppermann U, Hui R

Chemistry & biology. 2008 Dec 22;15(12):1296-306
Structure-activity relationships among the nitrogen containing bisphosphonates in clinical use and other analogues: time-dependent inhibition of human farnesyl pyrophosphate synthase.
Dunford JE, Kwaasi AA, Rogers MJ, Barnett BL, Ebetino FH, Russell RG, Oppermann U, Kavanagh KL

Journal of medicinal chemistry. 2008 Apr 10;51(7):2187-95
SALMON: solvent accessibility, ligand binding, and mapping of ligand orientation by NMR spectroscopy.
Ludwig C, Michiels PJ, Wu X, Kavanagh KL, Pilka E, Jansson A, Oppermann U, Günther UL

Journal of medicinal chemistry. 2008 Jan 10;51(1):1-3
Bisphosphonates: an update on mechanisms of action and how these relate to clinical efficacy.
Russell RG, Xia Z, Dunford JE, Oppermann U, Kwaasi A, Hulley PA, Kavanagh KL, Triffitt JT, Lundy MW, Phipps RJ, Barnett BL, Coxon FP, Rogers MJ, Watts NB, Ebetino FH

Annals of the New York Academy of Sciences. 2007 Nov;1117:209-57
Mechanism and substrate recognition of human holo ACP synthase.
Bunkoczi G, Pasta S, Joshi A, Wu X, Kavanagh KL, Smith S, Oppermann U

Chemistry & biology. 2007 Nov;14(11):1243-53
The scientific impact of the Structural Genomics Consortium: a protein family and ligand-centered approach to medically-relevant human proteins.
Gileadi O, Knapp S, Lee WH, Marsden BD, Müller S, Niesen FH, Kavanagh KL, Ball LJ, von Delft F, Doyle DA, Oppermann UC, Sundström M

Journal of structural and functional genomics. 2007 Sep;8(2-3):107-19
Crystal structures of histone demethylase JMJD2A reveal basis for substrate specificity.
Ng SS, Kavanagh KL, McDonough MA, Butler D, Pilka ES, Lienard BM, Bray JE, Savitsky P, Gileadi O, von Delft F, Rose NR, Offer J, Scheinost JC, Borowski T, Sundstrom M, Schofield CJ, Oppermann U

Nature. 2007 Jul 5;448(7149):87-91
Structural and biochemical characterization of human orphan DHRS10 reveals a novel cytosolic enzyme with steroid dehydrogenase activity.
Lukacik P, Keller B, Bunkoczi G, Kavanagh KL, Kavanagh K, Lee WH, Hwa Lee W, Adamski J, Oppermann U

The Biochemical journal. 2007 Mar 15;402(3):419-27
Reversible sequestration of active site cysteines in a 2Fe-2S-bridged dimer provides a mechanism for glutaredoxin 2 regulation in human mitochondria.
Johansson C, Kavanagh KL, Gileadi O, Oppermann U

The Journal of biological chemistry. 2007 Feb 2;282(5):3077-82
SDR-type human hydroxysteroid dehydrogenases involved in steroid hormone activation.
Wu X, Lukacik P, Kavanagh KL, Oppermann U

Molecular and cellular endocrinology. 2007 Feb;265-266:71-6
The crystal structure of human geranylgeranyl pyrophosphate synthase reveals a novel hexameric arrangement and inhibitory product binding.
Kavanagh KL, Dunford JE, Bunkoczi G, Russell RG, Oppermann U

The Journal of biological chemistry. 2006 Aug 4;281(31):22004-12
The molecular mechanism of nitrogen-containing bisphosphonates as antiosteoporosis drugs.
Kavanagh KL, Guo K, Dunford JE, Wu X, Knapp S, Ebetino FH, Rogers MJ, Russell RG, Oppermann U

Proceedings of the National Academy of Sciences of the United States of America. 2006 May 16;103(20):7829-34
Structure and function of human 17beta-hydroxysteroid dehydrogenases.
Lukacik P, Kavanagh KL, Oppermann U

Molecular and cellular endocrinology. 2006 Mar 27;248(1-2):61-71
Structure of human phytanoyl-CoA 2-hydroxylase identifies molecular mechanisms of Refsum disease.
McDonough MA, Kavanagh KL, Butler D, Searls T, Oppermann U, Schofield CJ

The Journal of biological chemistry. 2005 Dec 9;280(49):41101-10
The coenzyme specificity of Candida tenuis xylose reductase (AKR2B5) explored by site-directed mutagenesis and X-ray crystallography.
Petschacher B, Leitgeb S, Kavanagh KL, Wilson DK, Nidetzky B

The Biochemical journal. 2005 Jan 1;385(Pt 1):75-83
Studies of the enzymic mechanism of Candida tenuis xylose reductase (AKR 2B5): X-ray structure and catalytic reaction profile for the H113A mutant.
Kratzer R, Kavanagh KL, Wilson DK, Nidetzky B

Biochemistry. 2004 May 4;43(17):4944-54
Structure of Toxoplasma gondii LDH1: active-site differences from human lactate dehydrogenases and the structural basis for efficient APAD+ use.
Kavanagh KL, Elling RA, Wilson DK

Biochemistry. 2004 Feb 3;43(4):879-89
On the role of Brønsted catalysis in Pseudomonas fluorescens mannitol 2-dehydrogenase.
Klimacek M, Kavanagh KL, Wilson DK, Nidetzky B

The Biochemical journal. 2003 Oct 1;375(Pt 1):141-9
Structure of xylose reductase bound to NAD+ and the basis for single and dual co-substrate specificity in family 2 aldo-keto reductases.
Kavanagh KL, Klimacek M, Nidetzky B, Wilson DK

The Biochemical journal. 2003 Jul 15;373(Pt 2):319-26
Altering dimer contacts in xylose reductase from Candida tenuis by site-directed mutagenesis: structural and functional properties of R180A mutant.
Klimacek M, Wührer F, Kavanagh KL, Wilson DK, Nidetzky B

Chemico-biological interactions. 2003 Feb 1;143-144:523-32
Crystal structure of Pseudomonas fluorescens mannitol 2-dehydrogenase: evidence for a very divergent long-chain dehydrogenase family.
Kavanagh KL, Klimacek M, Nidetzky B, Wilson DK

Chemico-biological interactions. 2003 Feb 1;143-144:551-8
Pseudomonas fluorescens mannitol 2-dehydrogenase and the family of polyol-specific long-chain dehydrogenases/reductases: sequence-based classification and analysis of structure-function relationships.
Klimacek M, Kavanagh KL, Wilson DK, Nidetzky B

Chemico-biological interactions. 2003 Feb 1;143-144:559-82

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Kathryn L Kavanagh, Ph.D.

Principal Investigator

Determining crystal structures of human metabolic enzymes

Kathryn Kavanagh's Genealogy

Kathryn Kavanagh's Publications (28)