Howard Hughes Medical Institute and The Jackson Laboratory
Cell Biology
Duke University Medical Center and HHMI
Cell Biology
HHMI
Duke University School of Medicine (Durham, NC)
In humans, quality of life correlates directly with good vision. Nearly 161 million people globally are visually impaired as a result of diseases such as retinitis pigmentosa (RP), glaucoma and age related macular degeneration (AMD). These diseases are characterized by the degeneration of specialized membrane domains such as the photoreceptor outer segments, retinal ganglion cell axons and loss of apical-basal membrane domains in the retinal pigmented epithelium. I am interested in understanding the molecular mechanisms required for forming physiologically specialized membrane domains in retinal neurons and pigmented epithelial cells. I anticipate these studies will also provide insights into the pathology of disease affecting retinal neurons and pigmented epithelial cells.

The Adobe Flash Player plugin (version 8) is required to view the genealogy tree.
Download the plugin here.