Epernicus: Kari J Airenne

Kari J Airenne

Position:
Professor

AIV Institute

University of Kuopio (Kuopio, Finland)
Degrees:
Past Advisors:
Research:
(Baculo)virus-mediated gene delivery.

My current primary interest is in the baculovirus technology. My studies aim to: 1) improved production of recombinant proteins and 2)viruses and VLPs, 3)study virus cell interactions, and 4) develope improved vectors for gene delivery and therapeutic applications. My other interest include targeted drug delivery by avidin-biotin technology and therapeutic angiogenesis.

Communities:

Kari Airenne's Genealogy

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Kari Airenne's Publications (36)

Generation of lentivirus vectors using recombinant baculoviruses.
Lesch HP, Turpeinen S, Niskanen EA, Mähönen AJ, Airenne KJ, Ylä-Herttuala S

Gene therapy. 2008 Sep;15(18):1280-6
Targeting and purification of metabolically biotinylated baculovirus.
Kaikkonen MU, Viholainen JI, Närvänen A, Ylä-Herttuala S, Airenne KJ

Human gene therapy. 2008 Jun;19(6):589-600
Baculovirus-mediated immediate-early gene expression and nuclear reorganization in human cells.
Laakkonen JP, Kaikkonen MU, Ronkainen PH, Ihalainen TO, Niskanen EA, Häkkinen M, Salminen M, Kulomaa MS, Ylä-Herttuala S, Airenne KJ, Vihinen-Ranta M

Cellular microbiology. 2008 Mar;10(3):667-81
Non-invasive Imaging in Gene Therapy.
Räty JK, Liimatainen T, Unelma Kaikkonen M, Gröhn O, Airenne KJ, Jumani Airenne K, Ylä-Herttuala S

Molecular therapy : the journal of the American Society of Gene Therapy. 2007 Sep;15(9):1579-86
Post-transcriptional regulatory element boosts baculovirus-mediated gene expression in vertebrate cells.
Mähönen AJ, Airenne KJ, Purola S, Peltomaa E, Kaikkonen MU, Riekkinen MS, Heikura T, Kinnunen K, Roschier MM, Wirth T, Ylä-Herttuala S

Journal of biotechnology. 2007 Aug 1;131(1):1-8
Rhizavidin from Rhizobium etli: the first natural dimer in the avidin protein family.
Helppolainen SH, Nurminen KP, Määttä JA, Halling KK, Slotte JP, Huhtala T, Liimatainen T, Ylä-Herttuala S, Airenne KJ, Närvänen A, Jänis J, Vainiotalo P, Valjakka J, Kulomaa MS, Nordlund HR

The Biochemical journal. 2007 Aug 1;405(3):397-405
SPECT/CT imaging of baculovirus biodistribution in rat.
Räty JK, Liimatainen T, Huhtala T, Kaikkonen MU, Airenne KJ, Hakumäki JM, Närvänen A, Ylä-Herttuala S

Gene therapy. 2007 Jun;14(12):930-8
Magnetic resonance imaging of viral particle biodistribution in vivo.
Räty JK, Liimatainen T, Wirth T, Airenne KJ, Ihalainen TO, Huhtala T, Hamerlynck E, Vihinen-Ranta M, Närvänen A, Ylä-Herttuala S, Hakumäki JM

Gene therapy. 2006 Oct;13(20):1440-6
Truncated vesicular stomatitis virus G protein improves baculovirus transduction efficiency in vitro and in vivo.
Kaikkonen MU, Räty JK, Airenne KJ, Wirth T, Heikura T, Ylä-Herttuala S

Gene therapy. 2006 Feb;13(4):304-12
Short and long-term effects of hVEGF-A(165) in Cre-activated transgenic mice.
Leppänen P, Kholová I, Mähönen AJ, Airenne K, Koota S, Mansukoski H, Närväinen J, Wirzenius M, Alhonen L, Jänne J, Alitalo K, Ylä-Herttuala S

PLoS ONE. 2006;1:e13
Improvement in nuclear entry and transgene expression of baculoviruses by disintegration of microtubules in human hepatocytes.
Salminen M, Airenne KJ, Rinnankoski R, Reimari J, Välilehto O, Rinne J, Suikkanen S, Kukkonen S, Ylä-Herttuala S, Kulomaa MS, Vihinen-Ranta M

Journal of virology. 2005 Mar;79(5):2720-8
A multipurpose vector system for the screening of libraries in bacteria, insect and mammalian cells and expression in vivo.
Laitinen OH, Airenne KJ, Hytönen VP, Peltomaa E, Mähönen AJ, Wirth T, Lind MM, Mäkelä KA, Toivanen PI, Schenkwein D, Heikura T, Nordlund HR, Kulomaa MS, Ylä-Herttuala S

Nucleic acids research. 2005;33(4):e42
Efficient production of active chicken avidin using a bacterial signal peptide in Escherichia coli.
Hytönen VP, Laitinen OH, Airenne TT, Kidron H, Meltola NJ, Porkka EJ, Hörhä J, Paldanius T, Määttä JA, Nordlund HR, Johnson MS, Salminen TA, Airenne KJ, Ylä-Herttuala S, Kulomaa MS

The Biochemical journal. 2004 Dec 1;384(Pt 2):385-90
Optimized self-excising Cre-expression cassette for mammalian cells.
Mähönen AJ, Airenne KJ, Lind MM, Lesch HP, Ylä-Herttuala S

Biochemical and biophysical research communications. 2004 Jul 23;320(2):366-71
Construction of hevein (Hev b 6.02) with reduced allergenicity for immunotherapy of latex allergy by comutation of six amino acid residues on the conformational IgE epitopes.
Karisola P, Mikkola J, Kalkkinen N, Airenne KJ, Laitinen OH, Repo S, Pentikäinen OT, Reunala T, Turjanmaa K, Johnson MS, Palosuo T, Kulomaa MS, Alenius H

Journal of immunology (Baltimore, Md. : 1950). 2004 Feb 15;172(4):2621-8
Enhanced gene delivery by avidin-displaying baculovirus.
Räty JK, Airenne KJ, Marttila AT, Marjomäki V, Hytönen VP, Lehtolainen P, Laitinen OH, Mähönen AJ, Kulomaa MS, Ylä-Herttuala S

Molecular therapy : the journal of the American Society of Gene Therapy. 2004 Feb;9(2):282-91
Targeting of biotinylated compounds to its target tissue using a low-density lipoprotein receptor-avidin fusion protein.
Lehtolainen P, Wirth T, Taskinen AK, Lehenkari P, Leppänen O, Lappalainen M, Pulkkanen K, Marttila A, Marjomäki V, Airenne KJ, Horton M, Kulomaa MS, Ylä-Herttuala S

Gene therapy. 2003 Dec;10(25):2090-7
Baculovirus capsid display: a novel tool for transduction imaging.
Kukkonen SP, Airenne KJ, Marjomäki V, Laitinen OH, Lehtolainen P, Kankaanpää P, Mähönen AJ, Räty JK, Nordlund HR, Oker-Blom C, Kulomaa MS, Ylä-Herttuala S

Molecular therapy : the journal of the American Society of Gene Therapy. 2003 Nov;8(5):853-62
Baculovirus display strategies: Emerging tools for eukaryotic libraries and gene delivery.
Oker-Blom C, Airenne KJ, Grabherr R

Briefings in functional genomics & proteomics. 2003 Oct;2(3):244-53
Improved generation of recombinant baculovirus genomes in Escherichia coli.
Airenne KJ, Peltomaa E, Hytönen VP, Laitinen OH, Ylä-Herttuala S

Nucleic acids research. 2003 Sep 1;31(17):e101
Rational design of an active avidin monomer.
Laitinen OH, Nordlund HR, Hytönen VP, Uotila ST, Marttila AT, Savolainen J, Airenne KJ, Livnah O, Bayer EA, Wilchek M, Kulomaa MS

The Journal of biological chemistry. 2003 Feb 7;278(6):4010-4
Baculoviruses exhibit restricted cell type specificity in rat brain: a comparison of baculovirus- and adenovirus-mediated intracerebral gene transfer in vivo.
Lehtolainen P, Tyynelä K, Kannasto J, Airenne KJ, Ylä-Herttuala S

Gene therapy. 2002 Dec;9(24):1693-9
Chicken avidin-related proteins show altered biotin-binding and physico-chemical properties as compared with avidin.
Laitinen OH, Hytönen VP, Ahlroth MK, Pentikäinen OT, Gallagher C, Nordlund HR, Ovod V, Marttila AT, Porkka E, Heino S, Johnson MS, Airenne KJ, Kulomaa MS

The Biochemical journal. 2002 May 1;363(Pt 3):609-17
Cloning and characterization of Scavidin, a fusion protein for the targeted delivery of biotinylated molecules.
Lehtolainen P, Taskinen A, Laukkanen J, Airenne KJ, Heino S, Lappalainen M, Ojala K, Marjomäki V, Martin JF, Kulomaa MS, Ylä-Herttuala S

The Journal of biological chemistry. 2002 Mar 8;277(10):8545-50
Biotin induces tetramerization of a recombinant monomeric avidin. A model for protein-protein interactions.
Laitinen OH, Marttila AT, Airenne KJ, Kulik T, Livnah O, Bayer EA, Wilchek M, Kulomaa MS

The Journal of biological chemistry. 2001 Mar 16;276(11):8219-24

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Kari J Airenne

Professor

(Baculo)virus-mediated gene delivery.

Kari Airenne's Genealogy

Kari Airenne's Publications (36)