Epernicus: Jae-Hyuck Shim, Ph.D.

Jae-Hyuck Shim, Ph.D.

Positions:
Post Doctoral Fellow

Immunology and Infectious Diseases

Harvard School of Public Health (Boston, MA)

Post Doctoral Fellow

Immunology and Infectious Diseases

Harvard School of Public Health (Boston, MA)
Advisor:
Laurie H. Glimcher
Degrees:

Ph.D., Immunology, Yale School of Medicine (New Haven, CT)
Past Advisors:

Sankar Ghosh (as Graduate Student - Ph.D.)
Research:
Honors:
2008-2010 Arthritis foundation postdoctoral fellowship

Communities:

Jae-Hyuck Shim's Genealogy

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Jae-Hyuck Shim's Publications (9)

TAK1 is an essential regulator of BMP signalling in cartilage.
Shim JH, Greenblatt MB, Xie M, Schneider MD, Zou W, Zhai B, Gygi S, Glimcher LH

The EMBO journal. 2009 Jul 22;28(14):2028-41
H2O2-dependent hyperoxidation of peroxiredoxin 6 (Prdx6) plays a role in cellular toxicity via up-regulation of iPLA2 activity.
Kim SY, Jo HY, Kim MH, Cha YY, Choi SW, Shim JH, Kim TJ, Lee KY

The Journal of biological chemistry. 2008 Nov 28;283(48):33563-8
Roles for TAB1 in regulating the IL-1-dependent phosphorylation of the TAB3 regulatory subunit and activity of the TAK1 complex.
Mendoza H, Campbell DG, Burness K, Hastie J, Ronkina N, Shim JH, Arthur JS, Davis RJ, Gaestel M, Johnson GL, Ghosh S, Cohen P

The Biochemical journal. 2008 Feb 1;409(3):711-22
CHMP5 is essential for late endosome function and down-regulation of receptor signaling during mouse embryogenesis.
Shim JH, Xiao C, Hayden MS, Lee KY, Trombetta ES, Pypaert M, Nara A, Yoshimori T, Wilm B, Erdjument-Bromage H, Tempst P, Hogan BL, Mellman I, Ghosh S

The Journal of cell biology. 2006 Mar 27;172(7):1045-56
TAK1, but not TAB1 or TAB2, plays an essential role in multiple signaling pathways in vivo.
Shim JH, Xiao C, Paschal AE, Bailey ST, Rao P, Hayden MS, Lee KY, Bussey C, Steckel M, Tanaka N, Yamada G, Akira S, Matsumoto K, Ghosh S

Genes & development. 2005 Nov 15;19(22):2668-81
PDK1 nucleates T cell receptor-induced signaling complex for NF-kappaB activation.
Lee KY, D'Acquisto F, Hayden MS, Shim JH, Ghosh S

Science (New York, N.Y.). 2005 Apr 1;308(5718):114-8
A novel ubiquitin-like domain in IkappaB kinase beta is required for functional activity of the kinase.
May MJ, Larsen SE, Shim JH, Madge LA, Ghosh S

The Journal of biological chemistry. 2004 Oct 29;279(44):45528-39
Ecsit is required for Bmp signaling and mesoderm formation during mouse embryogenesis.
Xiao C, Shim JH, Klüppel M, Zhang SS, Dong C, Flavell RA, Fu XY, Wrana JL, Hogan BL, Ghosh S

Genes & development. 2003 Dec 1;17(23):2933-49
Immunosuppressive effects of tautomycetin in vivo and in vitro via T cell-specific apoptosis induction.
Shim JH, Lee HK, Chang EJ, Chae WJ, Han JH, Han DJ, Morio T, Yang JJ, Bothwell A, Lee SK

Proceedings of the National Academy of Sciences of the United States of America. 2002 Aug 6;99(16):10617-22

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Jae-Hyuck Shim, Ph.D.

Post Doctoral Fellow

Post Doctoral Fellow

Jae-Hyuck Shim's Genealogy

Jae-Hyuck Shim's Publications (9)