Epernicus: John R Horton, Ph.D.

John R Horton, Ph.D.

Position:
Assistant Professor

Biochemistry, Cell & Developmental Biology

Emory University (Atlanta, GA)
Degrees:

Ph.D., Biochemistry and Molecular Biophysics, Columbia University Medical Center (New York, NY)
Past Advisors:

Xiaodong Cheng (as Post Doctoral Fellow)

Jim Pflugrath (as Post Doctoral Fellow)

Wayne Hendrickson (as Graduate Student - Ph.D.)
Research:

Communities:

John Horton's Genealogy

The Adobe Flash Player plugin (version 8) is required to view the genealogy tree.
Download the plugin here.

John Horton's Publications (33)

Adding a lysine mimic in the design of potent inhibitors of histone lysine methyltransferases.
Chang Y, Ganesh T, Horton JR, Spannhoff A, Liu J, Sun A, Zhang X, Bedford MT, Shinkai Y, Snyder JP, Cheng X

Journal of molecular biology. 2010 Jul 2;400(1):1-7
Enzymatic and structural insights for substrate specificity of a family of jumonji histone lysine demethylases.
Horton JR, Upadhyay AK, Qi HH, Zhang X, Shi Y, Cheng X

Nature structural & molecular biology. 2010 Jan;17(1):38-43
Structural redesign of lipase B from Candida antarctica by circular permutation and incremental truncation.
Qian Z, Horton JR, Cheng X, Lutz S

Journal of molecular biology. 2009 Oct 16;393(1):191-201
Structural basis for G9a-like protein lysine methyltransferase inhibition by BIX-01294.
Chang Y, Zhang X, Horton JR, Upadhyay AK, Spannhoff A, Liu J, Snyder JP, Bedford MT, Cheng X

Nature structural & molecular biology. 2009 Mar;16(3):312-7
UHRF1, a modular multi-domain protein, regulates replication-coupled crosstalk between DNA methylation and histone modifications.
Hashimoto H, Horton JR, Zhang X, Cheng X

Epigenetics : official journal of the DNA Methylation Society. 2009 Jan;4(1):8-14
The SRA domain of UHRF1 flips 5-methylcytosine out of the DNA helix.
Hashimoto H, Horton JR, Zhang X, Bostick M, Jacobsen SE, Cheng X

Nature. 2008 Oct 9;455(7214):826-9
Dimeric Galectin-8 induces phosphatidylserine exposure in leukocytes through polylactosamine recognition by the C-terminal domain.
Stowell SR, Arthur CM, Slanina KA, Horton JR, Smith DF, Cummings RD

The Journal of biological chemistry. 2008 Jul 18;283(29):20547-59
The ankyrin repeats of G9a and GLP histone methyltransferases are mono- and dimethyllysine binding modules.
Collins RE, Northrop JP, Horton JR, Lee DY, Zhang X, Stallcup MR, Cheng X

Nature structural & molecular biology. 2008 Mar;15(3):245-50
Recognition of unmethylated histone H3 lysine 4 links BHC80 to LSD1-mediated gene repression.
Lan F, Collins RE, De Cegli R, Alpatov R, Horton JR, Shi X, Gozani O, Cheng X, Shi Y

Nature. 2007 Aug 9;448(7154):718-22
Two alternative conformations of S-adenosyl-L-homocysteine bound to Escherichia coli DNA adenine methyltransferase and the implication of conformational changes in regulating the catalytic cycle.
Liebert K, Horton JR, Chahar S, Orwick M, Cheng X, Jeltsch A

The Journal of biological chemistry. 2007 Aug 3;282(31):22848-55
Structure of the SANT domain from the Xenopus chromatin remodeling factor ISWI.
Horton JR, Elgar SJ, Khan SI, Zhang X, Wade PA, Cheng X

Proteins. 2007 Jun 1;67(4):1198-202
Structural basis of allele variation of human thiopurine-S-methyltransferase.
Wu H, Horton JR, Battaile K, Allali-Hassani A, Martin F, Zeng H, Loppnau P, Vedadi M, Bochkarev A, Plotnikov AN, Cheng X

Proteins. 2007 Apr 1;67(1):198-208
Structure and substrate recognition of the Escherichia coli DNA adenine methyltransferase.
Horton JR, Liebert K, Bekes M, Jeltsch A, Cheng X

Journal of molecular biology. 2006 Apr 28;358(2):559-70
The ubiquitin binding domain ZnF UBP recognizes the C-terminal diglycine motif of unanchored ubiquitin.
Reyes-Turcu FE, Horton JR, Mullally JE, Heroux A, Cheng X, Wilkinson KD

Cell. 2006 Mar 24;124(6):1197-208
DNA nicking by HinP1I endonuclease: bending, base flipping and minor groove expansion.
Horton JR, Zhang X, Maunus R, Yang Z, Wilson GG, Roberts RJ, Cheng X

Nucleic acids research. 2006;34(3):939-48
Structural basis for inhibition of histamine N-methyltransferase by diverse drugs.
Horton JR, Sawada K, Nishibori M, Cheng X

Journal of molecular biology. 2005 Oct 21;353(2):334-44
Transition from nonspecific to specific DNA interactions along the substrate-recognition pathway of dam methyltransferase.
Horton JR, Liebert K, Hattman S, Jeltsch A, Cheng X

Cell. 2005 May 6;121(3):349-61
Structure of HinP1I endonuclease reveals a striking similarity to the monomeric restriction enzyme MspI.
Yang Z, Horton JR, Maunus R, Wilson GG, Roberts RJ, Cheng X

Nucleic acids research. 2005;33(6):1892-901
Structure of the conserved core of the yeast Dot1p, a nucleosomal histone H3 lysine 79 methyltransferase.
Sawada K, Yang Z, Horton JR, Collins RE, Zhang X, Cheng X

The Journal of biological chemistry. 2004 Oct 8;279(41):43296-306
Caught in the act: visualization of an intermediate in the DNA base-flipping pathway induced by HhaI methyltransferase.
Horton JR, Ratner G, Banavali NK, Huang N, Choi Y, Maier MA, Marquez VE, MacKerell AD, Cheng X

Nucleic acids research. 2004;32(13):3877-86
Structure of the bacteriophage T4 DNA adenine methyltransferase.
Yang Z, Horton JR, Zhou L, Zhang XJ, Dong A, Zhang X, Schlagman SL, Kossykh V, Hattman S, Cheng X

Nature structural biology. 2003 Oct;10(10):849-55
Structural basis for the product specificity of histone lysine methyltransferases.
Zhang X, Yang Z, Khan SI, Horton JR, Tamaru H, Selker EU, Cheng X

Molecular cell. 2003 Jul;12(1):177-85
Structure of the Neurospora SET domain protein DIM-5, a histone H3 lysine methyltransferase.
Zhang X, Tamaru H, Khan SI, Horton JR, Keefe LJ, Selker EU, Cheng X

Cell. 2002 Oct 4;111(1):117-27
Structures of yeast ARF2 and ARL1: distinct roles for the N terminus in the structure and function of ARF family GTPases.
Amor JC, Horton JR, Zhu X, Wang Y, Sullards C, Ringe D, Cheng X, Kahn RA

The Journal of biological chemistry. 2001 Nov 9;276(45):42477-84
Two polymorphic forms of human histamine methyltransferase: structural, thermal, and kinetic comparisons.
Horton JR, Sawada K, Nishibori M, Zhang X, Cheng X

Structure (London, England : 1993). 2001 Sep;9(9):837-49

Show more publications...

Join Epernicus (membership is free)

Epernicus is open to current and former research scientists.

Already a member?
Sign in to view John's full profile.

John R Horton, Ph.D.

Assistant Professor

John Horton's Genealogy

John Horton's Publications (33)