Jason R Cook

Jason R Cook, B.A.

  • Position:
    MD/PhD student

    Pharmacology & Systems Therapeutics

    Mount Sinai School of Medicine (New York, NY)

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  • Advisor:

    Francesco Ramirez

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  • Degrees:
     
    B.A., Biology, Grinnell College (Grinnell, IA)
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  • Past Advisors:
     
    Diomedes Logothetis (as Graduate Student - Ph.D.)
     
    Basil Hanss (as Undergraduate Student)
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  • Research:
    Molecular Pathophysiology of Vascular Specific Manifestations in the Marfan Syndrome.

    The main objective of my work is to elucidate the interactions among discrete cell types and the extracellular matrix (ECM) leading to thoracic aortic aneurysm (TAA) formation in Marfan Syndrome (MFS), with the long-term goal of translating experimental findings into improved therapeutic strategies for congenital and acquired vascular aneurysm disorders. The premise of this work is that aortic tissue degeneration in MFS patients and mouse models is related to structural impairment of the ECM and inappropriate activation of latent transforming growth factor- (TGF) and MAPK-mediated stress response signals. To this end, I am focused on the following two projects:

    SA1: Cell-specific participation in development of thoracic aortic aneurysm and dilated cardiomyopathy in MFS

    SA2: Genetic interrogation of the mechanism underlying therapeutic advantage of AT1 antagonism in MFS

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  • Other Experience:

    2006 Mount Sinai School of Medicine Summer Undergraduate Research Program

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  • Honors:

    2011 Award for Outstanding Student Teaching in a Medical School Course, Mount Sinai School of Medicine

    2010 Award for Graduate Student Outstanding Teaching Award, Mount Sinai School of Medicine

    2009-2010 Rudin Foundation Scholar

Life Sciences
Communities:

Jason Cook's Genealogy

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Jason Cook's Publications (2)



Jason Cook's Posters and Presentations (4)

  • Inactivation of Fibrillin-1 in Vascular Smooth Muscle Cells (VSMCs) but not Endothelial Cells (ECs) replicates Thoracic Aortic Aneurysm (TAA) in Marfan Syndrome. (poster)

    Jason R Cook, L. Carta, M.del Solar, F. Ramirez

    Experimental Biology 2011; 04/2011
  • Characterization and Treatment of Osteopenia in Mice with Severe Marfan Syndrome (poster)

    Carta, L., H. Nistala, S. Lee-Arteaga, Jason Cook, S. Smaldone, A. Rifkin, and F. Ramirez

    8th International Research Symposium on Marfan Syndrome; 09/2010
  • Conditional Inactivation of Fibrillin-1 in Aortic Tissue Compartments (presentation)

    Jason R Cook, Sui Lee-Arteaga, Luca Carta, Harikiran Nistala, Maria del Solar, and Francesco Ramirez.

    8th International Research Symposium on Marfan Syndrome; 09/2010
  • Regulation of Cytosolic Malate Dehydrogenase Expression by Extracellular DNA (poster)

    Goddard G.M., Jason Cook, A. Teixeira, and B. Hanss

    Experimental Biology; 04/2007

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