John P Hagan

John P Hagan, Ph.D.

  • Positions:
    Researcher

    Hematology and Oncology

    Harvard Stem Cell Institute

    Children's Hospital Boston/Harvard Medical School

    Adjunct Research Assistant Professor

    Molecular Virology, Immunology and Medical Genetics

    The Ohio State University Medical Center (Columbus, OH)

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  • Advisors:

    Richard I Gregory, Carlo M Croce

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  • Degrees:
     
    Ph.D., Molecular, Cellular, and Developmental Biology, University of Pittsburgh (Pittsburgh, PA)
     
    B.S., Biology, Virginia Tech (Blacksburg, VA)
     
    B.S., Physics, Virginia Tech (Blacksburg, VA)
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  • Past Advisors:
     
    Colin L Stewart (as Post Doctoral Fellow)
     
    Paula J Grabowski (as Graduate Student - Ph.D.)
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  • Research:
    My primary scientific interest lies in understanding the role of microRNAs and TUTases in developmental and cancer biology where medulloblastoma is of particular interest.

    Briefly, post-transcriptional gene regulation in animals is accomplished in part by the actions of numerous RNA binding proteins and microRNAs. Although the widespread significance of TUTases in mammals is largely unknown, TUTases serve critical functions in lower organisms including fission yeast and nematodes by uridylating mRNAs, microRNAs, and other noncoding regulatory RNAs. Recently, we demonstrated that the mouse TUTase Zcchc11 is a key mediator in the Lin28 blockade of let-7 microRNA biogenesis. My future research goals are to understand the involvement of mammalian TUTases in gene regulation and to define the functional significance of these enzymes, in particular Zcchc11, in developmental and cancer biology. My working hypothesis is that TUTases serve critical roles in mammalian biology by modulating RNA abundance and/or function, affecting neural differentiation, cellular proliferation, and tumorigenesis. Since research on mammalian 3’ RNA uridylation is still in its infancy, the proposed work promises to lay the foundation for new fields of investigation into this largely unexplored mechanism of gene regulation.

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  • Other Experience:

    1998-2004 Postdoctoral Research Fellow (National Cancer Institute-Frederick)

    2001 Fast Paced Biology Instructor (Center for Talened Youth/Johns Hopkins University )

    1993-1998 Graduate Research Assistant (University of Pittsburgh)

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  • Honors:

    2008-present Sigma Xi (MIT Chapter)

    1989-1993 National Merit Scholar

    1989-1990 University Merit Scholar

Life Sciences
Communities:

John Hagan's Genealogy

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John Hagan's Publications (29)



One Figure

One Figure for John P Hagan

The RNA binding protein Lin28 recruits the TUTase Zcchc11 to block the maturation of the tumor suppressor let-7 microRNA family


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