Epernicus: Jillian Orans, Ph.D.

Jillian Orans, Ph.D.

Position:
Post Doctoral Fellow

Biochemistry

Duke University Medical Center (Durham, NC)
Advisor:
Lorena s Beese
Degrees:

Ph.D., Biological Chemistry, University of North Carolina at Chapel Hill (Chapel Hill, NC)

B.A., Chemistry, Vassar College (Poughkeepsie, NY)
Past Advisors:

Matthew R. Redinbo (as Graduate Student - Ph.D.)

Maria A. Gomez (as Undergraduate Student)
Research:
Structural Biology of DNA Repair Proteins
Other Experience:
2001 US Department of Energy, Research Intern, Idaho National Laboratory

Communities:

Jillian Orans's Genealogy

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Jillian Orans's Publications (8)

Structures of human exonuclease 1 DNA complexes suggest a unified mechanism for nuclease family.
Orans J, McSweeney EA, Iyer RR, Hast MA, Hellinga HW, Modrich P, Beese LS

Cell. 2011 Apr 15;145(2):212-23
Alleviating cancer drug toxicity by inhibiting a bacterial enzyme.
Wallace BD, Wang H, Lane KT, Scott JE, Orans J, Koo JS, Venkatesh M, Jobin C, Yeh LA, Mani S, Redinbo MR

Science (New York, N.Y.). 2010 Nov 5;330(6005):831-5
Crystal structure analysis reveals Pseudomonas PilY1 as an essential calcium-dependent regulator of bacterial surface motility.
Orans J, Johnson MD, Coggan KA, Sperlazza JR, Heiniger RW, Wolfgang MC, Redinbo MR

Proceedings of the National Academy of Sciences of the United States of America. 2010 Jan 19;107(3):1065-70
Residue-level interrogation of macromolecular crowding effects on protein stability.
Charlton LM, Barnes CO, Li C, Orans J, Young GB, Pielak GJ

Journal of the American Chemical Society. 2008 May 28;130(21):6826-30
Crystal structure of the pregnane X receptor-estradiol complex provides insights into endobiotic recognition.
Xue Y, Moore LB, Orans J, Peng L, Bencharit S, Kliewer SA, Redinbo MR

Molecular endocrinology (Baltimore, Md.). 2007 May;21(5):1028-38
Temperature-induced reversible conformational change in the first 100 residues of alpha-synuclein.
McNulty BC, Tripathy A, Young GB, Charlton LM, Orans J, Pielak GJ

Protein science : a publication of the Protein Society. 2006 Mar;15(3):602-8
The nuclear xenobiotic receptor pregnane X receptor: recent insights and new challenges.
Orans J, Teotico DG, Redinbo MR

Molecular endocrinology (Baltimore, Md.). 2005 Dec;19(12):2891-900
Structural disorder in the complex of human pregnane X receptor and the macrolide antibiotic rifampicin.
Chrencik JE, Orans J, Moore LB, Xue Y, Peng L, Collins JL, Wisely GB, Lambert MH, Kliewer SA, Redinbo MR

Molecular endocrinology (Baltimore, Md.). 2005 May;19(5):1125-34

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Jillian Orans, Ph.D.

Post Doctoral Fellow

Structural Biology of DNA Repair Proteins

Jillian Orans's Genealogy

Jillian Orans's Publications (8)