Epernicus: Jacky Chi Ki Ngo, Ph.D.

Jacky Chi Ki Ngo, Ph.D.

Position:
Research Assistant Professor

Biochemistry

The Chinese University of Hong Kong (Ma Liu Shui, Hong Kong)
Degrees:

Ph.D., Biochemistry, University of California, San Diego (San Diego, CA)

M.S., Biochemistry, University of California, San Diego (San Diego, CA)

B.S., Biochemistry, University of California, San Diego (San Diego, CA)
Past Advisors:

Bruce Furie (as Post Doctoral Fellow)

Gourisankar Ghosh (as Graduate Student - Ph.D.)
Research:
Honors:
2006-2008 NIH Kirschstein NRSA Postdoctoral Fellowship in Blood Coagulation and Vascular Biology

Communities:

Jacky Chi Ki Ngo's Genealogy

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Jacky Chi Ki Ngo's Publications (7)

Adaptable molecular interactions guide phosphorylation of the SR protein ASF/SF2 by SRPK1.
Hagopian JC, Ma CT, Meade BR, Albuquerque CP, Ngo JC, Ghosh G, Jennings PA, Fu XD, Adams JA

Journal of molecular biology. 2008 Oct 17;382(4):894-909
Crystal structure of human factor VIII: implications for the formation of the factor IXa-factor VIIIa complex.
Ngo JC, Huang M, Roth DA, Furie BC, Furie B

Structure (London, England : 1993). 2008 Apr;16(4):597-606
A sliding docking interaction is essential for sequential and processive phosphorylation of an SR protein by SRPK1.
Ngo JC, Giang K, Chakrabarti S, Ma CT, Huynh N, Hagopian JC, Dorrestein PC, Fu XD, Adams JA, Ghosh G

Molecular cell. 2008 Mar 14;29(5):563-76
SR protein kinase 1 is resilient to inactivation.
Ngo JC, Gullingsrud J, Giang K, Yeh MJ, Fu XD, Adams JA, McCammon JA, Ghosh G

Structure (London, England : 1993). 2007 Jan;15(1):123-33
Interplay between SRPK and Clk/Sty kinases in phosphorylation of the splicing factor ASF/SF2 is regulated by a docking motif in ASF/SF2.
Ngo JC, Chakrabarti S, Ding JH, Velazquez-Dones A, Nolen B, Aubol BE, Adams JA, Fu XD, Ghosh G

Molecular cell. 2005 Oct 7;20(1):77-89
Processive phosphorylation of alternative splicing factor/splicing factor 2.
Aubol BE, Chakrabarti S, Ngo J, Shaffer J, Nolen B, Fu XD, Ghosh G, Adams JA

Proceedings of the National Academy of Sciences of the United States of America. 2003 Oct 28;100(22):12601-6
Nucleotide-induced conformational changes in the Saccharomyces cerevisiae SR protein kinase, Sky1p, revealed by X-ray crystallography.
Nolen B, Ngo J, Chakrabarti S, Vu D, Adams JA, Ghosh G

Biochemistry. 2003 Aug 19;42(32):9575-85

Jacky Chi Ki Ngo's Posters and Presentations (5)

Crystal Structure of B Domain-deleted Factor VIII (presentation)
Jacky Chi Ki Ngo

Gordon Reseach Conference on Hemostasis; 07/2008
A Sliding Docking Interaction is Essential for Sequential Phosphorylation of ASF/SF2 by SRPK1 (presentation)
Jacky Chi Ki Ngo

National University of Singapore; 02/2008
Crystal Structure of B Domain-deleted Factor VIII (presentation)
Jacky Chi Ki Ngo

American Society of Hematology, Annual Meeting; 12/2007
Regulation of Tissue Factor: Conformational Changes in Tissue Factor Associated witht the Cleavage of Cysteine 186-Cysteine 209 Disulfide Bond (presentation)
Jacky Chi Ki Ngo

American Society of Hematology, Annual Meeting; 12/2007
SR Protein Kinase 1: Conformation, Substrate Recognition and Catalysis (presentation)
Jacky Chi Ki Ngo

The Chinese University of Hong Kong; 05/2007

One Figure

Crystal Structure of Human Factor VIII

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